First evidence of bluetongue virus serotype 16 in Croatia

Listeš, Eddy; Monaco, Federica; Labrović, Ankica; Paladini, C; Leone, Alessandra; Gialleonardo, Luigina Di; Cammà, Cesare; Savini, Giovanni

doi:10.1016/j.vetmic.2009.03.011

Cited by 14 publications

(9 citation statements)

References 13 publications

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“…host susceptibility, vector species and abundance) and abiotic conditions (climatic factors). A different case could be some strains belonging to serotype 16 where data are available for their current circulation in Italy (strain IT2004) and past circulation in Corsica and Croatia (FR2004 and CRO2004, Listeš et al., ), which are characterised by moderate, albeit variable, level of morbidity in small ruminants (median 1.7%; 0.4–16.3, 5th–95th percentiles), as well as case fatality, and very limited mortality rates, and speed of spread. However, experimental studies in naïve northern European sheep demonstrated that this virus serotype also has the capacity to be highly virulent, thus in line with what explained in Section 2.2 about the capacity of BTV serotype/strains to modify the virulence (Veronesi et al., ).…”

Section: Assessmentmentioning

confidence: 99%

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bluetongue

More¹,

Bicout²,

Bøtner³

et al. 2017

EFS2

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A specific concept of strain was developed in order to classify the BTV serotypes ever reported in Europe based on their properties of animal health impact: the genotype, morbidity, mortality, speed of spread, period and geographical area of occurrence were considered as classification parameters. According to this methodology the strain groups identified were (i) the BTV strains belonging to serotypes BTV-1-24, (ii) some strains of serotypes BTV-16 and (iii) small ruminant-adapted strains belonging to serotypes BTV-25, -27, -30. Those strain groups were assessed according to the criteria of the Animal Health Law (AHL), in particular criteria of Article 7, Article 5 on the eligibility of bluetongue to be listed, Article 9 for the categorisation according to disease prevention and control rules as in Annex IV and Article 8 on the list of animal species related to bluetongue. The assessment has been performed following a methodology composed of information collection, expert judgement at individual and collective level. The output is composed of the categorical answer, and for the questions where no consensus was reached, the different supporting views are reported. The strain group BTV (1-24) can be considered eligible to be listed for Union intervention as laid down in Article 5(3) of the AHL, while the strain group BTV-25-30 and BTV-16 cannot. The strain group BTV-1-24 meets the criteria as in Sections 2 and 5 of Annex IV of the AHL, for the application of the disease prevention and control rules referred to in points (b) and (e) of Article 9(1) of the AHL. The animal species that can be considered to be listed for BTV-1-24 according to Article 8(3) are several species of Bovidae, Cervidae and Camelidae as susceptible species; domestic cattle, sheep and red deer as reservoir hosts, midges insect of genus Culicoides spp. as vector species.

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Section: Assessmentmentioning

confidence: 99%

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bluetongue

More¹,

Bicout²,

Bøtner³

et al. 2017

EFS2

View full text Add to dashboard Cite

show abstract

“…More importantly, vaccination with these live virus vaccine strains can result in viremia sufficient for uptake and onward spread by Culicoides sp. vectors (11) leading to outbreaks (12) with devastating consequence for the farming industry. Potentially, this could lead to reversion to virulence and virulent reassortants (13).…”

Section: Introductionmentioning

confidence: 99%

Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines

Celma

Stewart

Wernike

et al. 2017

J Virol

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Bluetongue virus (BTV) is endemic in many parts of the world, often causing severe hemorrhagic disease in livestock. To date, at least 27 different serotypes have been recognized. Vaccination against all serotypes is necessary to protect susceptible animals and to prevent onward spread of the virus by insect vectors. In our previous studies, we generated replication-deficient (disabled infectious single-cycle [DISC]) virus strains for a number of serotypes and reported preliminary data on their protective efficacy in animals. In this report, to advance the DISC vaccines to the marketplace, we investigated different parameters of these DISC vaccines. First, we demonstrated the genetic stabilities of these vaccine strains and also the complementing cell line. Subsequently, the optimal storage conditions of vaccines, including additives, temperature, and desiccation, were determined and their protective efficacies in animals confirmed. Furthermore, to test if mixtures of different vaccine strains could be tolerated, we tested cocktails of DISC vaccines in combinations of three or six different serotypes in sheep and cattle, the two natural hosts of BTV. Groups of sheep vaccinated with a cocktail of six different vaccines were completely protected from challenge with individual virulent serotypes, both in early challenge and after 5 months of challenge without any clinical disease. There was no interference in protection between the different vaccines. Protection was also achieved in cattle with a mixture of three vaccine strains, albeit at a lesser level than in sheep. Our data support and validate the suitability of these virus strains as the next-generation vaccines for BTV.IMPORTANCE Bluetongue (BT) is a debilitating and in many cases lethal disease that affects ruminants of economic importance. Classical vaccines that afford protection against bluetongue virus, the etiological agent, are not free from secondary and undesirable effects. A surge in new approaches to produce highly attenuated, safer vaccines was evident after the development of the BTV reverse-genetics system that allows the introduction of targeted mutations in the virus genome. We targeted an essential gene to develop disabled virus strains as vaccine candidates. The results presented in this report further substantiate our previous evidence and support the suitability of these virus strains as the next-generation BTV vaccines.

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“…Gene reassortment between serotype 16 and/or BTV-7 and BTV-11 could explain the unexpected grouping. A double reassortant field isolate of BTV-16 was also isolated in 2002 in Italy, which contained a segment 2 derived from a SA BTV-16 MLV and a segment 5 derived from a SA BTV-2 MLV strain (38,22,42]. The neighbour-net analysis verifies the grouping of BTV-16 in the Western group 2 but rather illustrates reassortment between BTV-2 (KJ506696) which, in turn, is closely related to BTV-7 (KJ506695 and JX272558) (Fig.…”

Section: Discussionmentioning

confidence: 99%

Sequence analysis and evaluation of the NS3/A gene region of bluetongue virus isolates from South Africa

Steyn

Venter

2016

Arch Virol

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First evidence of bluetongue virus serotype 16 in Croatia

Cited by 14 publications

References 13 publications

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bluetongue

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bluetongue

Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines

Sequence analysis and evaluation of the NS3/A gene region of bluetongue virus isolates from South Africa

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