The practical utility of remote sensing techniques depends on their validation with ground-truth data. Validation requires similar spatial-temporal scales for ground measurements and remote sensing resolution. Evapotranspiration (ET) estimates are commonly compared to weighing lysimeter data, which provide accurate but localized measurements. To address this limitation, we propose the use of superconducting gravimeters (SGs) to obtain ground-truth ET data at larger spatial scales. SGs measure gravity acceleration with high resolution (tenths of nm s−2) within a few hundred meters. Similar to lysimeters, gravimeters provide direct estimates of water mass changes to determine ET without disturbing the soil. To demonstrate the practical applicability of SG data, we conducted a case study in Buenos Aires Province, Argentina (Lat: −34.87, Lon: −58.14). We estimated cumulative ET values for 8-day and monthly intervals using gravity and precipitation data from the study site. Comparing these values with Moderate Resolution Imaging Spectroradiometer (MODIS)-based ET products (MOD16A2), we found a very good agreement at the monthly scale, with an RMSE of 32.6 mm month−1 (1.1 mm day−1). This study represents a step forward in the use of SGs for hydrogeological applications. The future development of lighter and smaller gravimeters is expected to further expand their use.