First Experience in Humans Using Adipose Tissue–Derived Regenerative Cells in the Treatment of Patients With ST-Segment Elevation Myocardial Infarction

Houtgraaf, Jaco H.; Dekker, Wijnand K. den; Dalen, Bas M. van; Springeling, Tirza; Jong, Renate de; Geuns, Robert Jan van; Geleijnse, Marcel L.; Fernández‐Avilés, Francisco; Zijlsta, Felix; Serruys, Patrick W.; Duckers, Henricus J.

doi:10.1016/j.jacc.2011.09.065

Cited by 284 publications

(215 citation statements)

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“…Liposuction is one of most common esthetic surgical procedures worldwide, and it generates an average of 100-3000 mL of adipose tissue that is routinely discarded, along with its incorporated stem cells 2 . In addition to being easily obtained, adipose-derived stem cells (ADSCs) also have significant therapeutic use 3 , as an acute myocardial infarction 4 and bone regeneration 5 . However, according to cellular therapy protocols used in clinical trials, more than one million stem cells are necessary per treatment, necessitating in vitro expansion 6 .…”

mentioning

confidence: 99%

Proliferation of human adipose tissue-derived stem cells stimulated by oil rich in thymol of Lippia origanoides

Brito

Vendramin²,

Lopes³

et al. 2018

Acta Cir. Bras.

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1 5-Experimental SurgeryActa Cir Bras. 2018;33(5):431-438 Abstract Purpose: To evaluate the effects of this thymol-rich oil in the proliferation of human adipose tissue-derived stem cells. Methods: Stem cells were isolated from human adipose tissue by liposuction . After the first passage, cells were cultivated in triplicate for three days in control medium and medium supplemented with three oil samples (1.0 μg/mL, 5.0 μg/mL, and 25.0 μg/mL). Cells were analyzed by the MTT assay at passage 1 (P1), and cell proliferation of control and 1 μg/mL groups was determined with a hemocytometer at P2 and P3. Results: Viability of the essential oil-treated cells was significantly higher than the control group at P1 (p = 0.0008). The treatment with the oil, at a concentration of 1 µg/mL, led to increases of 24.8% at P1 and 43.0% at P3 in the rate of cell proliferation compared with control cells. Conclusion: Supplementing culture medium with essential oil of Lippia origanoides increased cell proliferation, especially at later passages.

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mentioning

confidence: 99%

Proliferation of human adipose tissue-derived stem cells stimulated by oil rich in thymol of Lippia origanoides

Brito

Vendramin²,

Lopes³

et al. 2018

Acta Cir. Bras.

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“…[39] In the phase III clinical trial of intracoronary infusion of ADSC in the treatment of acute myocardial infarction, the cardiac function of patients injected with ADSC was improved and no serious adverse events occurred. [40] The application of stem cells in the treatment of heart disease is still in its infancy, and its mechanism, methods, safety & efficacy, and transplant rejection need to be scientifically demonstrated by a large number of in-depth multicenter randomized controlled trials.…”

Section: Treatment Of Heart Diseasementioning

confidence: 99%

Advances in the research of basic study and clinical application of adipose-derived mesenchymal stem cells

Sheng-jun

Wang

et al. 2018

DCC

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Since the discovery of adipose-derived mesenchymal stem cell (ADSC) in more than ten years, a great progress has been made from its basic research to clinical application. Compared with bone marrow mesenchymal stem cells, ADSC is more abundant in reserve, easier to obtain with fewer injuries and less complications. These cells have multiple differentiation potential and can differentiate into adipocytes, chondrocytes and osteoblasts with the influence of different inducing factors. Early studies of ADSC mainly focused on the ability of multi-directional differentiation, especially on the regeneration of bone defects and cartilage tissue. At present, the researches mainly focus on immunoregulation and paracrine function of ADSC. Although ADSC has made a great progress in clinical application, the cell preparation, use pattern, and mechanisms in clinical treatment are not clear. This paper elaborates on these issues.

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“…27, Many demonstrated improvement in EF, 27,[44][45][46][47][48][49][50][51][52]55,56,59,61 volumes, 27,[43][44][45]47,48,[50][51][52]59 wall motion, [43][44][45][47][48][49] and infarct size [43][44][45]47,54,61 when compared with conventional treatment. REPAIR-AMI showed decreased mortality, recurrent AMI, and HF re-hospitalizations, 51 with maintained improvement at two years.…”

Section: Clinical Outcomes Acute Myocardial Infarctionmentioning

confidence: 99%

“…Both trials demonstrated the efficacy of ASC in AMI and left ventricular dysfunction in settings of marked myocardial ischemia. 61,80 Landmark, large-scale trials using BMC showed benefits in neovascularization, ventricular function and remodeling. [12][13][14] The ACT-34 study demonstrated that EPC mobilization, isolation and injection significantly improved recurrent angina.…”

Section: Dilated Cardiomyopathymentioning

confidence: 99%

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Stem Cell Therapy for Heart Disease

2013

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Coronary artery disease is the leading cause of death in Americans. After myocardial infarction, significant ventricular damage persists despite timely reperfusion and pharmacological management. Treatment is limited, as current modalities do not cure this damage. In the past decade, stem cell therapy has emerged as a promising therapeutic solution to restore myocardial function. Clinical trials have demonstrated safety and beneficial effects in patients suffering from acute myocardial infarction, heart failure, and dilated cardiomyopathy. These benefits include improved ventricular function, increased ejection fraction, and decreased infarct size. Mechanisms of therapy are still not clearly understood. However, it is believed that paracrine factors, including stromal cell-derived factor-1, contribute significantly to stem cell benefits. The purpose of this article is to provide medical professionals with an overview on stem cell therapy for the heart and to discuss potential future directions.

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First Experience in Humans Using Adipose Tissue–Derived Regenerative Cells in the Treatment of Patients With ST-Segment Elevation Myocardial Infarction

Cited by 284 publications

References 4 publications

Proliferation of human adipose tissue-derived stem cells stimulated by oil rich in thymol of Lippia origanoides

Proliferation of human adipose tissue-derived stem cells stimulated by oil rich in thymol of Lippia origanoides

Advances in the research of basic study and clinical application of adipose-derived mesenchymal stem cells

Stem Cell Therapy for Heart Disease

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