First experience in the use of bone marrow mesenchymal stem cells for the treatment of a patient with deep skin burns

Расулов, М Ф; Васильченков, А. В.; Онищенко, Н. А.; Крашенинников, М. Е.; Кравченко, В. И.; Горшенин, Т. Л.; Пидцан, Р. Е.; Потапов, И. В.

doi:10.1007/s10517-005-0232-3

Cited by 168 publications

(107 citation statements)

References 10 publications

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“…Preclinical human studies have investigated the effect of MSC treatment on chronic wounds, 6,7 burns, 8 radiation wounds, 9 and blistering skin disorders. 10 The results from these studies and animal models have been promising with positive outcomes on wound repair.…”

Section: Background Bone Marrow-derived Mscs Improve Wound Healingmentioning

confidence: 99%

The Role of Chemokines in Mesenchymal Stem Cell Homing to Wounds

Hocking

2015

Advances in Wound Care

151

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Significance: Mesenchymal stem cells (MSCs) are being administered to cutaneous wounds with the goal of accelerating wound closure and promoting regeneration instead of scar formation. An ongoing challenge for cell-based therapies is achieving effective and optimal targeted delivery and engraftment at the site of injury. Contributing to this challenge is our incomplete understanding of endogenous MSC homing to sites of injury. Recent Advances: Chemokines and their receptors are now recognized as important mediators of stem cell homing. To date, the most studied chemokinechemokine receptor axis in MSC homing to wounds is CXCL12-CXCR4 but recent work suggests that CCL27-CCR10 and CCL21-CCR7 may also be involved. Critical Issues: Strategies to enhance chemokine-mediated MSC homing to wounds are using a variety of approaches to amplify the chemokine signal at the wound site and/or overexpress specific chemokine receptors on the surface of the MSC. Future Directions: Harnessing chemokine signaling may enhance the therapeutic effects of stem cell therapy by increasing the number of both exogenous and endogenous stem cells recruited to the site of injury. Alternatively, chemokine-based therapies directly targeting endogenous stem cells may circumvent the need for the time-consuming and costly isolation and expansion of autologous stem cells prior to therapeutic administration. SCOPE AND SIGNIFICANCEMesenchymal stem cells (MSCs) are being administered to cutaneous wounds with the goal of accelerating wound closure and promoting regeneration instead of scar formation.1 An ongoing challenge for cell-based therapies is achieving effective and optimal targeted delivery and engraftment at the site of injury. Contributing to this challenge is our incomplete understanding of endogenous MSC homing to sites of injury.2 This review will summarize our current knowledge about the role of chemokines in MSC recruitment to wounds. TRANSLATIONAL RELEVANCEThe translational relevance for research defining the chemokines responsible for stem cell homing is significant with a direct impact on stem cell therapy. Harnessing chemokine signaling may enhance the therapeutic effects of stem cell therapy by increasing the number of both exogenous and endogenous stem cells recruited to the site of injury. Alternatively, chemokine-based therapies directly targeting endogenous stem cells may circumvent the need for the time-consuming and costly isolation and expansion of autologous stem cells prior to therapeutic administration. CLINICAL RELEVANCEOngoing clinical trials are investigating the safety and efficacy of MSC therapy for the treatment of

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Section: Background Bone Marrow-derived Mscs Improve Wound Healingmentioning

confidence: 99%

The Role of Chemokines in Mesenchymal Stem Cell Homing to Wounds

Hocking

2015

Advances in Wound Care

151

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“…11,[15][16][17][18] Despite these immune-enhancing properties of MSCs, they have been reported to suppress immune rejection in different species, including human and nonhuman primates. [19][20][21] However, tolerance of MSCs across the allogeneic barrier might not be absolute since studies by another group report on experimental evidence that questions the status of immune privilege. 22 The expression of MHC-II expression on MSCs raises 2 concerns.…”

Section: Introductionmentioning

confidence: 99%

Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-γ

Chan

Tang

Patel

et al. 2006

Blood

401

307

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“…A level equal to or greater than 10 6 organism per gram of tissue is strongly related to impaired wound healing. [3][4][5][6][7] It has been demonstrated that bone marrow-derived mesenchymal stem cells (BMSCs) can promote the healing of compromised wound, 8,9 probably because of their plasticity in differentiation, 10,11 secreting cytokines and growth factors critical to wound healing, 12,13 low immunogenic property 14 and immunomodulatory function. 15 BMSCs are demonstrated to be potent carriers for exogenous genes.…”

Section: Introductionmentioning

confidence: 99%