First experience of Candida non-albicans isolates with high antibiotic resistance pattern caused oropharyngeal candidiasis among cancer patients

Kalantar, Enayatollah; Marashi, Seyed Mahmoud Amin; Pormazaheri, Helen; Mahmoudi, Elaheh; Hatami, Shiva; Barari, M; Naseh, Mohammad Hadi; Asadi, Mojan

doi:10.4103/0973-1482.157307

Cited by 9 publications

(5 citation statements)

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“…Various authors have documented the prevalence of Candida in oral cancerous lesions ranging from 68% to 86%. [ 3 16 17 19 20 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 2 ] Candida , though a commensal, can also cause oral mucosal infections in immunocompromised situations which are frequently seen in older individuals, infants, people infected with HIV, and individuals with cancer. [ 3 ] Colonization may lead to either a sustained or transient saprophytic association with the host or localized infections of mucosal surfaces. [ 2 ] There is significant association between histologically determined fungal infection of the oral mucosa and epithelial dysplasia.…”

Section: Introductionmentioning

confidence: 99%

“…[ 2 ] There is significant association between histologically determined fungal infection of the oral mucosa and epithelial dysplasia. [ 3 ] Candida might induce oral squamous cell carcinoma (OSCC) by directly producing carcinogenic compounds, for example, nitrosamines. [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

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Candidal species identification in malignant and potentially malignant oral lesions with antifungal resistance patterns

et al. 2018

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Objective:Candidal species identification in malignant and potentially malignant oral lesions with antifungal susceptibility.Materials and Methods:Oral candidal carriage, strain diversity, and antifungal susceptibility of Candida were checked for the patients having oral cancer or precancer reporting to the clinics for 1½ year. Statistically significant patients were selected and a control group was taken. A total of 105 individuals were selected and divided into three different groups. Salivary samples were taken from all the individuals. Candida detection was done using Sabouraud's agar and candidal species detection on CHROMagar. In vitro antifungal sensitivity was done using antifungal disc diffusion method.Results:Candida was isolated from 88.6% of patients with oral cancer and 45.7% in oral precancerous group. C. albicans was the predominant species found in 100% of oral precancerous and 71% in oral cancerous patients. Other Candid a species found were C. tropicalis (9.7%) and C. krusei (19.6%). Antifungal susceptibility showed 4.3% sensitivity to fluconazole and 100% sensitivity to amphotericin B and nystatin.Conclusion:Oral Candida carriage was higher in oral cancerous group and majority of them were sensitive to amphotericin B and nystatin.

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“…Various authors have documented the prevalence of Candida in oral cancerous lesions ranging from 68% to 86%. [ 3 16 17 19 20 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Candidal species identification in malignant and potentially malignant oral lesions with antifungal resistance patterns

et al. 2018

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“…[ 3 4 5 ] There is a connection between epithelial dysplasia and histologically determined fungal infection of the oral mucosa. [ 6 ] It is suggested that Candida albicans tubular hyphal structure is needed because it allows for the entrance of precursors from saliva and the release of the nitrosamine agent into keratinocytes, possibly causing OSCC. [ 7 8 9 ] The ability of specific C. albicans strains to promote neoplastic transformation and the development of carcinogenic nitrosamines from saliva has revealed Candida's crucial role in malignant transformation.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Candidal Species among People Who Suffer from Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

Abidullah

Bhosle

Komire

et al. 2021

Journal of Pharmacy and Bioallied Sciences

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Aim and Objective: The aim of the present study was to evaluate the candidal species among masses with oral potentially malignant disorders and oral squamous cell carcinoma. Materials and Methods: This prospective and observational study was conducted by the Department of Oral Pathology and Microbiology, S. B. Patil Dental College, Bidar, Karnataka, India, from February 2018 to January 2019. The study composed of total of 150 individuals, of which 50 individuals did not had any visible manifestations, 50 were analyzed with potentially malignant disorders (PMDs) in particular oral leukoplakia, oral lichen planus, and oral submucous fibrosis and last group of 50 individuals were suffering from oral squamous cell carcinoma (OSCC). First, the swab samples were elicited from culture technique after that incisional biopsy of the discernible investigated lesion was done for the purpose of justopathological verification. The swab samples were streak on Sabouraud dextrose agar (SDA) and HiCrome Candida Differential HiVeg agar/CHROMagar medium and incubation at 37°C for 24–48 h. Biopsy was done for all the samples. Results: The proportion of candidates as men and women in control was 45 (90%) and 5 (10%), in PMD was 30 (60%) and 20 (40%), and in OSCC was 45 (90%) and 5 (10%), correspondingly. On evaluation on SDA medium in controls, PMD and OSCC groups, Candida was founded in 14 (28%), 20 (40%), and 42 (84%) and not founded in 36 (72%), 30 (60%), and 8 (16%) folks, subsequently. Intragroup contrast illustrated exceedingly necessary distinction with P = 0.000 between both controls versus OSCC and PMD in comparison to OSCC. Nevertheless, controls versus PMD manifested insignificant, P = 0.119. Investigation on CHROM AGAR media among controls, PMD and OSCC groups, Candida species was seen in 11 (22%), 19 (38%), and 40 (80%) and absent in 39 (78%), 31 (62%), and 10 (20%) individuals, respectively. On statistical inspection, the variations noted were enormous, (P = 0.000). On speciation of Candida in CHROM agar among the controls, PMD and OSCC groups, Candida albicans species was present in 9 (18%), 16 (32%), and 6 (12%), Candida krusei in 3 (6%), 6 (12%), and 13 (26%), Candida glabrata in 0, 0, and 8 (16%), and Candida tropicalis in 0, 0, and 3 (6%) cases, respectively. Nonetheless, only OSCC group reveal amalgamation of species such as C. glabrata and C. krusei was present in 2 (4%) case, C. tropicalis and C. krusei in was present 3 (6%) cases, C. tropicalis and C. glabrata was present in 2 (4%) case, C. albicans and C. tropicalis was present in 2 (4%) cases, and C. krusei, C. glabrata with C. albicans was present in 1 (2%) case, respectively. All other types of fungi were regarded as infectious excluding Candida, on analysis on SDA medium, infestation in the form of fungal molds was seen in 18 (36%) in controls, 12 (24%) in PMD and 8 (16%) in OSCC groups. Conclusion: We interpreted that the chief carrier of candidal species in PMDs and OSCC, yet more light is to be thrown on the topic that Candida has particular establishment in PMDs or in malignancy.

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“…Oral candidiasis is mostly treated with antifungal agents, some of which select for strains of Candida spp. resistant to such antimicrobial agents (173, 174). Therefore, there is a current need for preventive and therapeutic strategies for oral diseases that aim at restoring a healthy microbiome and increase its resistance to dysbiotic perturbations.…”

Section: Introductionmentioning

confidence: 99%

Ecological Therapeutic Opportunities for Oral Diseases

2017

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SUMMARY The three main oral diseases of humans, that is caries, periodontal diseases and oral candidiasis, are associated with microbiome shifts initiated by changes in the oral environment and/or decreased effectiveness of mucosal immune surveillance. In this review we discuss the role that microbial-based therapies may have in the control of these conditions. Most investigations on the use of microorganisms for management of oral disease have been conducted with probiotic strains with some positive but very discrete clinical outcomes. Other strategies such as whole oral microbiome transplantation or modification of community function by enrichment with health-promoting indigenous oral strains may offer more promise but research in this field is still in its infancy. Any microbial-based therapeutics for oral conditions, however, are likely to be only one component within a holistic preventive strategy that should also aim at modification of the environmental influences responsible for the initiation and perpetuation of microbiome shifts associated with oral dysbiosis.

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First experience of Candida non-albicans isolates with high antibiotic resistance pattern caused oropharyngeal candidiasis among cancer patients

Cited by 9 publications

References 0 publications

Candidal species identification in malignant and potentially malignant oral lesions with antifungal resistance patterns

Candidal species identification in malignant and potentially malignant oral lesions with antifungal resistance patterns

Investigation of Candidal Species among People Who Suffer from Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

Ecological Therapeutic Opportunities for Oral Diseases

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