First experiences using reflectance confocal microscopy on equivocal skin lesions in Queensland

Curchin, Claudia; Wurm, Elisabeth M. T.; Lambie, Duncan; Longo, Caterina; Pellacani, Giovanni; Soyer, H. Peter

doi:10.1111/j.1440-0960.2011.00756.x

Cited by 23 publications

(49 citation statements)

References 20 publications

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“…not done on new set of patients were excluded. Finally eight studies [21,[26][27][28][29][30][31][32] met the criteria to be included for meta analysis. The evidence level of the studies was determined as per the NICE guidelines on development methods [33].…”

Section: Methodological Qualitymentioning

confidence: 99%

“…All selected studies had CLSM done on either a single or more than one type of skin cancer and normal peri-lesional skin [26] and/or benign lesions [21,[27][28][29][30][31][32]. The skin cancers included melanoma, BCC and SCC and the benign lesions included seborrheic keratosis [21,30], benign melanocytic lesions [21,[27][28][29][30][31][32], actinic keratosis [21,29,31,32], sebaceous hyperplasia [21], acne [21], rosacea [21], wart [21], molluscum contagiosum [21], cutaneous T cell lymphoma [21], eczema [21, dermatofibroma[21,30,31], tinea [21], vascular lesions [30] and Bowen's disease [31] etc. Five studies [21,[26][27][28][29] were done on one type of skin cancer.…”

Section: Included Studiesmentioning

confidence: 99%

“…Five studies [21,[26][27][28][29] were done on one type of skin cancer. In 3 studies more than one skin cancer was included in the study population [30][31][32]. The study by Longo C et al [30] included all 3 types of skin cancer i.e.…”

Section: Included Studiesmentioning

confidence: 99%

“…Guitera P et al [31] devised MM and BCC algorithms. Studies by Curchin C et al [32] and Guitera P et al [31] grouped lesions of SCC together with pre malignant condition, actinic keratosis, so the results were not used in meta-analysis.…”

Section: Included Studiesmentioning

confidence: 99%

“…In order to carry out meta-analysis the studies were split into three groups depending on the type of cancer that CLSM was used to detect. There were only two studies for the diagnosis of SCC [26,30], four and six studies for BCC [21,[30][31][32] and melanoma [27][28][29][30][31][32] respectively . The results of the studies for BCC and melanoma were pooled separately, as they were of clinically similar patients and methodologies.…”

Section: Included Studiesmentioning

confidence: 99%

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2015

Journal of Cancer Research and Therapeutic Oncology

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Background: Nonmelanoma skin cancer (Basal Cell Cancer (BCC) and Squamous Cell Cancer (SCC)) are the most prevalent cancer in the light-skinned population. The incidence of melanoma has been increasing steadily throughout the world. Early recognition of skin cancer without doing biopsy remains challenging. The development of noninvasive diagnostic technologies is highly relevant and desired. Confocal Laser Scanning Microscopy (CLSM) enables in vivo and ex vivo imaging of human skin at a quasi-histologic resolution. Methods and Materials: Several databases like Medline, Embase, all EBM reviews (ACP Journal Club, Cochrane Controlled Trials Register, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects) and Journals@Ovid were used to perform a literature search on CLSM in the diagnosis of melanoma and non melanoma skin cancers. Standards for Reporting of Diagnosis Accuracy (STARD) initiative checklist and National Institute for Health and Clinical Excellence (NICE) guidelines on methodology were used to assess the quality of the studies found. Eight studies fulfilling relevant criteria inclusive of assessment of diagnostic accuracy of CSLM and histopathology were selected. Heterogeneity among the studies was assessed and the data was pooled for meta-analysis. Results:The eight included studies did not have considerable heterogeneity between them. The pooled sensitivity for melanoma diagnosis was 91.4% and for BCC diagnosis was 90.1%. Pooled specificities were 79.9% and 92.6% for malignant melanoma and BCC respectively. Diagnostic odds ratios for melanoma and BCC were 80.1 and 358.1 respectively. Conclusions: From the limited good quality available literature we found that CLSM has the potential to be an additional noninvasive diagnostic test to dermoscopy for the diagnosis of BCC and melanoma.

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