First French live-birth after oocyte vitrification performed before chemotherapy for fertility preservation

Perrin, Jeanne; Saïas-Magnan, J.; Broussais, F. J. V.; Bouabdallah, Réda; D’ercole, C.; Courbière, Blandine

doi:10.1007/s10815-016-0674-8

Cited by 9 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In all studies included in data extraction and analysis, a total of 647 patients in 8 studies explicitly opted for oocyte cryopreservation [ 14 , 15 , 16 , 30 , 31 , 32 , 33 , 34 ]. The total number of live births resulting explicitly from oocyte cryopreservation was 175 ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

Ovarian Tissue Cryopreservation versus Other Fertility Techniques for Chemoradiation-Induced Premature Ovarian Insufficiency in Women: A Systematic Review and Future Directions

Chaudhri,

Salman,

Awartani

et al. 2024

Life

View full text Add to dashboard Cite

Current advances in cancer therapy have increased survival, emphasizing the need for life quality improvement. Fertility loss is common post-chemotherapy. Current guidelines establish embryo and oocyte cryopreservation to address premature ovarian insufficiency (POI). Ovarian tissue cryopreservation has also recently become an acceptable option for fertility preservation, particularly as it is the only option for pre-pubertal patients. Few definitions for optimum fertility outcomes, and few systematic reviews comparing embryo, oocyte, and ovarian tissue cryopreservation as a means of fertility preservation (FP) in pre- and post-pubertal female cancer patients exist. This systematic review aims to improve understanding of gonadotoxic effects of chemoradiation therapy in cancer patients, to analyze the different fertility preservation techniques and procedures available to women with chemoradiation induced ovarian insufficiency, and to compare and recognize the benefits of each technique in restoring fertility, sexual hormone function, and quality of life. Searches were conducted electronically on PubMed, Cochrane, and EBSCOHost, including clinical trials, prospective, and retrospective studies of female cancer patients undergoing anti-cancer therapy, with predefined MeSH terminology. Data were collected, analyzed, and compared. Non-randomized clinical studies were evaluated for risk bias through the Newcastle–Ottawa Scale. In total, 23 studies were included. From there, 647 patients opted for oocyte cryopreservation, 267 for embryo cryopreservation, and 1382 for ovarian tissue cryopreservation (OTC). A total of 175, 18, and 121 live births resulted respectively from oocyte, embryo, and OTC, respectively. Studies without live births discussed other fertility markers as indicators of improvement in sexual hormone function and fertility. The gonadotoxic effects of chemotherapy call for FP intervention. Oocyte and embryo cryopreservation/implantation are well-established procedures. With changing trends and life quality consideration, OTC is a promising interventional method for pre-pubertal patients facing the prospect of fertility loss.

show abstract

Section: Resultsmentioning

confidence: 99%

Ovarian Tissue Cryopreservation versus Other Fertility Techniques for Chemoradiation-Induced Premature Ovarian Insufficiency in Women: A Systematic Review and Future Directions

Chaudhri,

Salman,

Awartani

et al. 2024

Life

View full text Add to dashboard Cite

show abstract

“…A total of 22 live births have been reported so far in cancer patients who preserved fertility through oocyte cryopreservation [7,10,11,31,[38][39][40][41][42][43][44][45]50,52,53].…”

Section: Discussionmentioning

confidence: 99%

Successful Pregnancies, Births, and Children Development Following Oocyte Cryostorage in Female Cancer Patients During 25 Years of Fertility Preservation

Porcu

Cipriani

Dirodi

et al. 2022

Cancers

View full text Add to dashboard Cite

The preservation of fertility in cancer patients is a crucial aspect of modern reproductive medicine. Amenorrhea and infertility often occur after cancer therapy, worsening the quality of life. Cryopreservation of oocytes in young cancer patients is a therapeutic option for preserving fertility. A prospective study was conducted on 508 cancer patients who underwent oocyte cryopreservation to preserve fertility between 1996 and 2021 including the COVID-19 pandemic period. Patients underwent ovarian stimulation, followed by egg retrieval, and oocytes were cryopreserved by slow freezing or vitrification. Sixty-four thawing/warming cycles were performed. Survival, fertilization, pregnancy, and birth rate over the thawing/warming cycles were obtained. The data were compared with those from a group of 1042 nononcological patients who cryopreserved supernumerary oocytes. An average of 8.8 ± 6.9 oocytes were retrieved per cycle, and 6.1 ± 4.2 oocytes were cryopreserved. With their own stored oocytes, 44 patients returned to attempt pregnancy. From a total of 194 thawed/warmed oocytes, 157 survived (80%). In total, 100 embryos were transferred in 57 transfer/cycles, and 18 pregnancies were achieved. The pregnancy rate per transfer and pregnancy rate per patient were 31% and 41%, respectively. No statistically significant differences were observed between oncological patients and nononcological patients. A total of 15 babies were born from oncological patients. Children born showed normal growth and development. One minor malformation was detected.

show abstract

“…More recently, oocyte cryopreservation has become a valid alternative for women who do not have a male partner and do not wish to resort to a sperm donor [3][4][5]. Overall, a small number of live births have been reported from fertilization of thawed oocytes in patients having received cancer therapies, most of them as single case reports or retrospective studies [6][7][8]. Some authors report that cancer patients tend to have a low ovarian reserve and an inadequate response to stimulation protocols, resulting in inferior numbers of oocytes retrieved when compared to age-matched non-oncologic women [9].…”

Section: Discussionmentioning

confidence: 99%

“…Oocyte freezing and thawing proved to be an efficient method for fertility preservation [4,5]. Nevertheless, small numbers of successful pregnancies and live births from oocyte cryopreservation have been reported in female cancer survivors, especially in patients with hematological malignancies [6][7][8]. This is the first report of a follicular lymphoma (FL) patient who carried out a healthy twin pregnancy through fertilization of the oocytes cryopreserved before chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

"First Twin Live-Birth Deliver After Oocyte Cryopreservation in a Follicular Lymphoma Patient"

Argnani

2022

BJSTR

View full text Add to dashboard Cite

First French live-birth after oocyte vitrification performed before chemotherapy for fertility preservation

Abstract: International audienceno abstrac

Cited by 9 publications

References 18 publications

Ovarian Tissue Cryopreservation versus Other Fertility Techniques for Chemoradiation-Induced Premature Ovarian Insufficiency in Women: A Systematic Review and Future Directions

Ovarian Tissue Cryopreservation versus Other Fertility Techniques for Chemoradiation-Induced Premature Ovarian Insufficiency in Women: A Systematic Review and Future Directions

Successful Pregnancies, Births, and Children Development Following Oocyte Cryostorage in Female Cancer Patients During 25 Years of Fertility Preservation

"First Twin Live-Birth Deliver After Oocyte Cryopreservation in a Follicular Lymphoma Patient"

Contact Info

Product

Resources

About