First-generation antipsychotics use and reduced risk of pneumonia—Clinical implications in SARS-CoV2 treatment: A systematic review and meta-analysis of observational studies

Eby, Abhirami; Jacob, Elsa; George, P. Samuel Gideon

doi:10.7324/japs.2022.120917

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…23,24 Our previously published article on the systematic review and meta-analysis studying the effect of antipsychotics on respiratory function provide the evidence that FGAs are particularly associated with a lower risk for pneumonia compared to exposure to other psychotropics drugs, whereas SGAs are more significantly associated with the development of pneumonia. 25 Studies have reported the increased risk of respiratory illness, including pneumonia and respiratory failure following Benzodiazepine (BZD) usage. The current and recent past use of BZD is related to a higher chance of pneumonia occurrence.…”

Section: Introductionmentioning

confidence: 99%

Risk of Respiratory Diseases with Use of Psychotropic Drugs: Results of a Community-based Cross-sectional Study from South India

Eby,

Dang,

Jacob

2023

Ind. J. Pharm. Edu. Res

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Background:The study evaluated the effect of various psychotropics on pulmonary function to identify the psychotropic drug class most commonly associated with risk of respiratory disorders. Since psychotropic medications have safety concerns for usage in general population, their use in people with Coronavirus Disease (COVID-19) is considered challenging. The study may also serve to draw evidence-based practical recommendations for the treatment of people with COVID-19. Materials and Methods: A 10-item containing questionnaire was designed to capture clinical information regarding psychotropic use and respiratory disorders. Internal consistency and reproducibility were determined using Cronbach's alpha and intra-class correlation coefficient respectively. A validated questionnaire was administered to patients or caregivers at a community pharmacy setup and data was collected through electronic data capture. All captured data were summarized descriptively and statistically analyzed using R Studio 4.0. Results: Cronbach's alpha and intra-class correlation coefficient values were found to be 0.92 and 0.85 respectively. In a sample of 198 patients, benzodiazepines were the commonly used medication (43.9%) followed by selective serotonin reuptake inhibitors (21.2%), anti-psychotics (15.1%), mood stabilizers (7.6%) and others (12.2%). A statistically significant association was observed between benzodiazepine, second-generation antipsychotics, and respiratory disorders p<0.1]). However, the use of first-generation antipsychotics was found to be less associated with respiratory infections. Conclusion: Benzodiazepine and second-generation antipsychotics were found to be significantly associated with respiratory disorders. Hence patients on psychotropics should be monitored for respiratory symptoms and the choice of anti-psychotic medications should be on existing clinical evidence. The psychotropics which were found to be safer through the study can be chosen to improve the quality of psychiatric care in COVID-19 patients, also promoting an optimal management of psychiatric conditions without worsening the medical condition due to COVID-19.

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Section: Introductionmentioning

confidence: 99%

Risk of Respiratory Diseases with Use of Psychotropic Drugs: Results of a Community-based Cross-sectional Study from South India

Eby,

Dang,

Jacob

2023

Ind. J. Pharm. Edu. Res

View full text Add to dashboard Cite

show abstract

“…23,24 Our previously published article on the systematic review and metaanalysis studying the effect of antipsychotics on respiratory function provide the evidence that FGAs are particularly associated with a lower risk for pneumonia compared to exposure to other psychotropics drugs, whereas SGAs are more signi cantly associated with the development of pneumonia. 25 Studies have reported the increased risk of respiratory illness, including pneumonia and respiratory failure following benzodiazepine (BZD) usage. The current and recent past use of BZD is related to a higher chance of pneumonia occurrence.…”

mentioning

confidence: 99%

Risk of respiratory diseases with use of psychotropic drugs: Results of a community-based cross-sectional study from South India

Eby¹,

Jacob²,

P³

2022

Preprint

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Background A cross-sectional study was conducted using a validated questionnaire among patients on psychotropic medications or their caregivers at a community pharmacy. The study evaluated the effect of various psychotropic drugs on pulmonary function to identify the psychotropic drug class most commonly associated with risk of respiratory disorders. Since psychotropic medications have safety concerns for usage in the general population, their use in people with coronavirus disease (COVID-19) is considered challenging. The study may also serve to draw evidence based practical recommendations for the treatment of people with COVID-19. Results Cronbach’s alpha and Intra class correlation coefficient values were found to be 0.92 and 0.85 respectively. In a sample of 198 patients, benzodiazepines were the commonly used medication among the population (43.9%) followed by selective serotonin re-uptake inhibitors (21.2%), anti-psychotics (15.1%), mood stabilizers (7.6%) and others (12.2%). Statistically significant association was observed between history of benzodiazepine usage, second generation antipsychotics and respiratory disorders (OR 1.56 [1.1–2.3, P < 0.1]). However the use of first generation antipsychotics were found to be less associated with respiratory infections. Conclusion History of benzodiazepine and second generation antipsychotic usage were found to be associated significantly with respiratory disorders including pneumonia and acute respiratory distress. Hence patients on psychotropics should be monitored for respiratory symptoms and choice of anti-psychotic medications should be made on existing clinical evidence. Psychotropic drugs which were found to be safer through the study conducted can be chosen to help improve the quality of psychiatric care in people with COVID-19, also promoting an optimal management of the psychiatric condition without worsening the medical condition due to COVID-19.

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First-generation antipsychotics use and reduced risk of pneumonia—Clinical implications in SARS-CoV2 treatment: A systematic review and meta-analysis of observational studies

Cited by 2 publications

References 19 publications

Risk of Respiratory Diseases with Use of Psychotropic Drugs: Results of a Community-based Cross-sectional Study from South India

Risk of Respiratory Diseases with Use of Psychotropic Drugs: Results of a Community-based Cross-sectional Study from South India

Risk of respiratory diseases with use of psychotropic drugs: Results of a community-based cross-sectional study from South India

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