First Heart Sound splitting

Cossio, P; Pr, Cossio; Kreutzer, E; Pm, Cossio; Cg, Matienzo

doi:10.1159/000168513

Cited by 4 publications

(2 citation statements)

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“…Agreement between immunofluores cence and immunoperoxidase techniques was present in all chagasic specimens stud ied. The direct immunofluorescence technique showed the so-called EVI pattern [2,3,7] ( fig. 2): deposits oflgA and IgG gave positive staining at the interstitial area, capillaries, and endocardium (EVI pattern) in patients No.…”

Section: Resultsmentioning

confidence: 99%

“…An explanation for some of these queries was formerly reported by Cossio's team [2,3], They showed [2] by indirect immunofluorescence that a circulating serum gamma globulin factor reacted with the endo cardium. interstitium, and blood vessels of the heart (EVI antibody) in patients suffering from Chagas' heart disease and in Trypano soma cruzi pathogen-free patients with sero logical positivity to CHDis.…”

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confidence: 97%

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Chronic Chagas’ Myocardiopathy

Molina¹,

Milei²,

Storino³

1984

Cardiology

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Chagas’ disease (CHDis) has been described as the commonest form of chronic myocarditis. Although autoimmune phenomena involving the myocardium have been suggested in both human and experimental CHDis, no immunoperoxidase techniques have been used for the detection of immunological deposits in chronic Chagas’ myocardiopathy (ChrCHM). The goal of this paper was to show that there is a coincidence between the immunoperoxidase and the immunofluorescence techniques in evidencing autologous deposits in ChrCHM. 4 patients suffering from ChrCHM were selected; their ages ranged from 39 to 52 years (x: 48.5 years). The Shültze and Caves endocavitary bioptome via the right internal jugular vein was used to obtain 3 to 4 right endomyocardial specimens measuring 1–2 mm each. Direct immunofluorescence examination, immunoperoxidase technique (PAP), and routine histological procedure were performed in all cases. Agreement between immunofluorescence and immunoperoxidase techniques was present in all chagasic specimens studied. Patients suffering from ChrCHM showed deposits of IgG, IgA, IgM, and C3 at the interstitial area, capillaries and endocardium and/or myocardial fiber surfaces when serum EVI antibody was positive. Serum EVI antibody was found to be positive in 3 out of 4 patients. The presence of the complement together with immunoglobulin may suggest an immune reaction (in vivo bound immunoglobulins in heart structures) and not just a passive deposition secondary to myocardial damage. As EVI antibody is present to a significant extent in CHDis, a reliable and simple technique like immunoperoxidase may be helpful to clarify the role of these antibodies in the pathogenesis of CHDis.

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confidence: 99%

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confidence: 97%