First human case of catheter-related blood stream infection caused by Staphylococcus schleiferi subspecies coagulans: a case report and literature review

Abstract

Background Staphylococcus schleiferi is a gram-positive pathogenic coccus which causes canine skin and ear infections. Only four cases of human infection caused by Staphylococcus schleiferi subspecies coagulans have been reported. Herein, we present the first case of catheter-related bloodstream infection caused by S. schleiferi subspecies coagulans. Case presentation A 62-year-old Japanese man was admitted to our hospital for examination of sigmoid colon tumor. During hospitalization, he had fever, shaking chills, and swelling at the peripheral venous catheter insertion site. Two sets of blood cultures were positive for S. schleiferi subspecies coagulans which was confirmed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), 16S ribosomal RNA sequencing and the coagulase test. The patient was successfully treated without relapse. Conclusion To our knowledge, this is the first report of catheter-related bloodstream infection caused by S. schleiferi subspecies coagulans. S. schleiferi subsp. coagulans can be pathogenic in humans, and MALDI-TOF MS can contribute to accurate identification of S. schleiferi subspecies coagulans.

Complete genome sequence of a Staphylococcus condimenti isolated from a port catheter-associated bloodstream infection

“…The report adds to evidence ( 3 , 5 – 7 , 14 ) that S. condimenti is able to cause invasive disease in predisposed individuals. Genomic information from invasive isolates may support food safety efforts in the future.…”

“…Staphylococcus condimenti was first described in 1998 as a subgroup of Staphylococcus carnosus ( 1 ), a coagulase-negative staphylococcus (CoNS) employed in food starter cultures for the characteristic flavor of sausages and cured ham ( 2 ). CoNS relevant in food processing, including S. condimenti , are rarely associated with human disease ( 3 – 7 ).…”

Staphylococcus schleiferi: An Uncommon Pathogen in an Immunocompetent Adolescent with Chronic Osteomyelitis

“…Of the two subspecies, S. schleiferi subsp. schleiferi is more commonly associated with human infections, specifically of wounds, surgical sites, osteomyelitis, and bacteremia [ 4 , 8 ]. In clinical settings, subspecies identification is typically not performed since treatment depends on antibiograms and the location of the infection.…”

Staphylococcus schleiferi subspecies coagulans septic shock in an immunocompetent male following canine otitis externa

“…schleiferi . [ 11 12 ] This is relevant, given the S. schleiferi ssp. coagulans identified in this patient, his immunocompetent status, and the severe clinical sequelae as a result of bacteremia following probable zoonotic canine transmission.…”