First human imaging with MARS photon-counting CT

Panta, Raj K.; Butler, Anthony; Butler, P. H.; Ruiter, Niels J A de; Bell, Stephen T.; Walsh, Michael F.; Doesburg, R.; Chernoglazov, Alexander I.; Goulter, Brian P.; Carbonez, Pierre; Damet, J.; Adebileje, Sikiru A; Alexander, Steven D.; Amma, Maya R; Anjomrouz, Marzieh; Asghariomabad, Fatemeh; Atharifard, Ali; Baer, Kenzie; Bamford, Benjamin; Bheesette, S.; Chambers, Claire; Dahal, Shishir; Dalefield, Tara; Duncan, Neryda; Gieseg, Steven P.; Gurney, Sam; Healy, Joseph L.; Hilton, Peter; Kanithi, Preveenkumar; Kirkbride, Tracy; Lansley, Stuart P.; Lowe, Chiara; Mandalika, V. B. H.; Marfo, Emmanuel; Matanaghi, Aysouda; Moghiseh, Mahdieh; Palmer, David N.; Prebble, Hannah M.; Raja, Aamir; Ramyar, Mohsen; Renaud, Peter; Schleich, Nanette; Searle, Emily; Shamshad, Muhammad; Sheeja, Jereena S; Uddin, Rayhan; Broeke, Lieza Vanden; Vivek, V.; Walker, E. Peter; Wijesooriya, Manoj; Woodfield, Tim B. F.

doi:10.1109/nssmic.2018.8824513

Cited by 15 publications

(17 citation statements)

References 51 publications

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“…A small-bore spectral micro-CT based on a Medipix-detector with 8 energy channels has been translated to a large-bore photon counting CT capable of obtaining diagnostic spectral CT images of a human within a clinical radiation dose level [68], however, no further results have been published yet.…”

Section: Pre-clinical Evaluation Of Photon-counting Ctmentioning

confidence: 99%

Photon-counting CT review

et al. 2020

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Photon-counting detectors are a promising new technology for computed tomography (CT) systems. They provide energy-resolved CT data at very high spatial resolution without electronic noise and with improved tissue contrasts. This review article gives an overview of the principles of photon-counting detector CT, of potential clinical benefits and limitations, and of the experience gained so far in pre-clinical installations.

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Section: Pre-clinical Evaluation Of Photon-counting Ctmentioning

confidence: 99%

Photon-counting CT review

et al. 2020

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“…The average absorbed dose of the mice with standard deviation was 27.3 ± 2.4 mGy, falling below the radiation dose range of small animal imaging (100-300 mGy) for conventional micro CT [41]. Results from our study show the potential to identify and quantify antibodies, liposomes, or micelles labeled with high-Z metal elements in living mouse models with less radiation dose using photon-counting spectral CT. More recently, a study conducted by our group showed that the MARS photon-counting scanner technology can be translated to scan living humans at a similar spatial resolution to this study [2].…”

Section: Discussionmentioning

confidence: 59%

“…P HOTON-COUNTING CT imaging is on the horizon of clinical radiology [1], [2]. It measures the energy of every detected X-ray photon with high spectral resolution and high contrast sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Material Identification Errors, Image Quality, and Radiation Doses Using Small Animal Spectral Photon-Counting CT

Marfo

Anderson

Butler

et al. 2021

IEEE Trans. Radiat. Plasma Med. Sci.

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Photon-counting CT offers the potential to provide new diagnostic information. In this study, we sought to determine the interplay between material identification errors, image quality indicators, and radiation doses using photon-counting spectral CT, and to determine whether this relationship is replicated in spectral CT scans of mice. Custom-built Perspex phantoms were used to measure signal-to-noise ratio (SNR) and spatial resolution, and to measure radiation dose using thermoluminescent dosimeters. A multicontrast calibration phantom containing inserts with different concentrations of gadolinium (1, 2, 4, and 8 mg/mL), hydroxyapatite rods (0, 54.3, 104.3, 211.7, 402.3, and 808.5 mg/mL) along with water and lipid was used to assess material identification errors. Image acquisition was performed using the MARS photon-counting scanner with four energy channels (30-45, 45-60, 60-78, and 78-118 keV) at four different tube currents (24, 34, 44, and 55 µA). As increased tube current showed no significant effect on material characterization,

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“…CSM refers to communication between pixels, where an incidental charge cloud spread over neighboring pixels is summed and allocated to the pixel that registered the highest charge. This technique minimizes the effect of charge sharing when using very small pixels (110 µm), which improves energy and spatial resolution [19]. The four counters operating in CSM were used in the current study.…”

Section: Introductionmentioning

confidence: 99%