First In-Vivo Diffuse Optics Application of a Time-Domain Multiwavelength Wearable Optode

Abstract

The optode is an innovative, ultra-compact (few cm 3 ) multiwavelength system for timedomain diffuse optics. We present here the first in-vivo measurements that benefit from this technological breakthrough.

The Solus Instrument: Optical Characterization of the First Hand-Held Probe for Multimodal Imaging (Ultrasound and Multi-Wavelength Time-Resolved Diffuse Optical Tomography)

“…Finally, although this study was centered on breast cancer imaging utilizing an 8-optode probe, it is important to note that the individual optode opens up exciting possibilities for wearable applications of diffuse optics, including monitoring of hemodynamics and tracking of brain activation, as previously explored [58], as well as non-destructive quality assessment for industrial-level fruit inspection. These diverse fields represent promising avenues for future exploration.…”

Initial examples of the SOLUS multimodal potential

“…The cutting-edge technological novelty introduced by SOLUS is the first ever miniaturization of multi-wavelength timeresolved DOT. This has been possible thanks to the expertise in photonics and imaging of the project partners, who designed and fabricated the so-called "smart optode" [2], a stand-alone module containing 8 picosecond pulsed lasers (640, 675, 830, 905, 930, 970, 1020, 1050 nm), a wide-area fast-gated Silicon Photomultiplier and an integrated Time-to-Digital converter [3]. 8 smart optodes are arranged on the sides of a regular ultrasound transducer for US, CD and SWE (Aixplorer Mach 30 by Hologic SuperSonic Imagine S.A.) yielding a handheld multimodal probe for medical imaging.…”

Towards time-domain diffuse optics with extreme photon rate

“…Recently, devices miniaturization by several orders of magnitude has been obtained by different researchers (see e.g., [4], [5]), as well as an increased measurement rate, thus permitting for instance to distinguish the heart beat pattern in functional Near-Infrared Spectroscopy (fNIRS) applications (see e.g., [4], [6]), as already widely achieved by continuous wave DO. In Ref.…”