“…Existing research has documented the numerous social and health consequences associated with long-term heroin use including blood-borne pathogen infections, depression, and high frequency overdoses (Chitwood et al, 2000; Hser, 2007; Rajaratnam, Sivesind, Todman, Roane, & Seewald, 2008; Rosen, Hunsaker, Albert, Cornelius, & Reynolds, 2011; Rosen, Smith, & Reynolds, 2008). Although the public health implications have been consistently documented, the debate concerning the “natural history” or “drug career” of long-term heroin use is ongoing (Best, Ghufran, Day, & Ray, 2008; Genberg et al, 2011; Hser, Hoffman, Grella, & Anglin, 2001; Hser, Longshore, & Anglin, 2007; Weiss et al, 2014).…”