First insight into human extrahepatic metabolism of flame retardants: Biotransformation of EH-TBB and Firemaster-550 components by human skin subcellular fractions

Abdallah, Mohamed Abou-Elwafa; Nguyen, Khanh Hoang; Moehring, Thomas J.; Harrad, Stuart

doi:10.1016/j.chemosphere.2019.04.017

Cited by 13 publications

(6 citation statements)

References 39 publications

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“…2019 ). Similarly, microsomal preparation of human skin demonstrated the ability of carboxylesterases to efficiently generate DPhP from TPhP ( Abdallah et al. 2019 ), indicating that the likelihood of TPhP reaching subcutaneous fat and blood through this route of exposure is very low.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters

Selmi-Ruby

Marín-Sáez

Fildier

et al. 2020

Environ Health Perspect

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Section: Introductionmentioning

confidence: 99%

In Vivo Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters

Selmi-Ruby

Marín-Sáez

Fildier

et al. 2020

Environ Health Perspect

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“…Although the default minimum peak intensity is 1,000,000 in Compound Discoverer, thresholds as low as 1000 have been used by others in metabolomics workflows successfully. 32,33 We chose a signal threshold of 2000 to maximize sensitivity so as to annotate as many suspect compounds as possible. This greatly increased the number of false positive peaks.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…This was a difficult test for the software, given the low concentration of spikes, small injection volume, high resolution (reduced number of data points relative to lower resolution acquisition), and the low peak threshold. Although the default minimum peak intensity is 1,000,000 in Compound Discoverer, thresholds as low as 1000 have been used by others in metabolomics workflows successfully. , We chose a signal threshold of 2000 to maximize sensitivity so as to annotate as many suspect compounds as possible. This greatly increased the number of false positive peaks.…”

Section: Resultsmentioning

confidence: 99%

Untargeted Screening in a Case Control Study Using Apples as a Matrix

Bakota

Levine

2020

J. Agric. Food Chem.

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Untargeted screening using high resolution mass spectrometry (HRMS) is a promising approach for screening the food supply for contaminants, but the sheer amount of information inherent to the HRMS data set presents analytical challenges. Red apples, collected during the U.S. FDA’s Total Diet Study, were studied to determine whether bioinformatic software can be used to distinguish spiked model compounds from those native to apples. A workflow was created, in which initial data sets of over 44,000 features in each of the two spiked samples were reduced by several orders of magnitude to a scale suitable for visual inspection. After visual inspection to address degeneracy and data quality, the final data sets contained 30 and 2 suspect compounds, respectively. To the best of our knowledge, this is the largest scale case-control study on food matrices to date and the first use of market basket samples as references in an untargeted screening study.

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“…Additionally, studies have shown that skin carboxylesterases participate in the metabolic transformation of pollutants. 41 Consequently, the metabolic processes of UVs in skin warrant further exploration.…”

Section: Dermal Uptake and Percutaneous Penetration Of Uvs In The Ski...mentioning

confidence: 99%

Percutaneous Penetration and Dermal Exposure Risk Assessment of UV Absorbents in Sunscreens and Isolation Cosmetics

Bai,

Li,

Guo

et al. 2024

Environ. Health

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Ultraviolet absorbents (UVs) make up a group of industrial chemicals that is used in various consumer products and industrial applications. Due to their extensive production and usage, UVs have been detected in multiple environmental matrixes. Recently, UVs have garnered significant attention because of their probable adverse impacts on human health and the environment. This study examines UVs levels in sunscreens and isolation cosmetics and further assesses human exposure to UVs through the application of cosmetics. The total concentrations of nine UVs in 87 sunscreen and isolation cosmetic products ranged from 75.5 to 4.25 × 104 ng/g. Among them, 2-(2-hydroxy-5-methyl-phenyl)benzotriazole (UV-P) and 2-hydroxy-4-(octoxy)benzophenone (UV-531) had the highest concentrations. Use of the EpiSkin model indicated rapid absorption and strong dermal penetration by UV-328 following 36 h of exposure with a cumulative absorption rate of 41.8% ± 2.82%. Other congeners are expected to be distributed in the dermal tissue and donor fluid. Furthermore, this study explored potential mechanisms implicating skin biochemical barriers in the metabolism and transport of UVs. The potential of UVs to act as substrates and inhibitors of P450 enzymes was assessed, and their metabolites were predicted. Molecular docking simulations demonstrated that UVs can significantly interact and bind with three transport proteins in skin: MDR1, OATP2B1, and OATP3A1. Daily UVs exposure through the skin was assessed, revealing that dermal absorption levels of UV-P in sunscreen sprays (4.66 × 103 ng/(kg bw day)) and sunscreens (6.01 × 103 ng/(kg bw day)) were close to or exceeded the reference dose (RfD) and therefore require more attention.

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First insight into human extrahepatic metabolism of flame retardants: Biotransformation of EH-TBB and Firemaster-550 components by human skin subcellular fractions

Cited by 13 publications

References 39 publications

In Vivo Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters

In Vivo Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters

Untargeted Screening in a Case Control Study Using Apples as a Matrix

Percutaneous Penetration and Dermal Exposure Risk Assessment of UV Absorbents in Sunscreens and Isolation Cosmetics

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