First Insights into the Unexplored Two-Component System YehU/YehT in Escherichia coli

Bacterial peptide transporters: Messengers of nutrition to virulence

“…74 Nutrient starvation also induces the expression of YehU/YehT, the only 2 component system known to regulate cst genes, in E. coli as well as in Salmonella. 72,75 TppB is transcriptionally regulated by leucine and anaerobiosis in Salmonella, 76 whereas in E. coli, the tppB homolog ydgR is regulated by EnvZ/OmpR 2 component system, 77 showing its involvement in stress response. The stationary phase specific sigma factor RpoS, which is known to regulate several virulence factors required in mammalian host, induces the expression of OppA2 in B. burgdorferi.…”

“…Commencement of nutrient starvation in stationary phase of growth is reported to induce carbon starvation (Cst) family of PTR peptide transporters, i.e., CstA and YjiY, via cAMP, in E. coli and Salmonella. 13,[71][72][73] In E. coli. the exponential phase specific global regulator protein CsrA negatively regulates the translation of CstA by binding to cstA mRNA.…”

“…52 Presence of peptides is also shown to induce the expression of peptide transporters in E. coli. 71,72 One of the mechanisms behind this regulation is addressed in an industrially important species Lactococcus lactis, which is commonly studied for peptide transport. L. lactis depends on its peptide transporters DtpT from the PTR family and Opp and Opt from the ABC transporter family, for growth during the manufacturing of various fermented dairy products.…”

Identification of a Target Gene and Activating Stimulus for the YpdA/YpdB Histidine Kinase/Response Regulator System in Escherichia coli

“…We have recently characterized the YehU/YehT system of E. coli (15). Not only does this LytS/LytTR-like TCS share the same domain structure with the YpdA/YpdB system, their respective components also show over 30% amino acid sequence identity.…”

The hierarchic network of metal-response transcription factors in Escherichia coli

“…36) For determination of the sequences of protein-bound SELEX DNA fragments, two procedures are employed, SELEX-clos (cloning and sequencing) Notes: The comprehensive transcriptome of all of E. coli TCS reveals and confirms the set of genes regulated by several response regulators. 109) In addition, all TCS of E. coli K-12 have been characterized by the efforts to analyze unidentified response regulators, CitA-CitB, 110,111) CreCCreB, 112) GlrK/QseE-GlrR/QseF, 113,114) QseC-QseB, 105) RstB-RstA, 102) YehU-YehT, 115) and YpdA-YpdB. 116) This represents the signal transduction system of all TCSs of E. coli K-12, which are classified into three groups by regulatory functions.…”