First isolation of Bunyamwera virus (Bunyaviridae family) from horses with neurological disease and an abortion in Argentina

Tauro, Laura B.; Rivarola, María Elisa; Lucca, E.; Mariño, Betina; Mazzini, R.; Cardoso, Jedson Ferreira; Barrandeguy, M.; Nunes, Márcio Roberto Teixeira; Contigiani, Marta Silvia

doi:10.1016/j.tvjl.2015.06.013

Cited by 34 publications

(34 citation statements)

References 7 publications

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“…It is interesting to note that compounds such as haloperidol and fluoxetine possess highly desirable drug properties in a clinical setting; good oral bioavailability (60–70%), generally well tolerated with severe side effects uncommon and the ability to cross the blood brain barrier ( 63 , 69 ). This may be pertinent for bunyavirus treatment since BUNV infection in both mouse and horses is largely neurotropic ( 70 , 71 ). Indeed BUNV infection was permissive in U87-MG cells; a human primary glioblastoma cell line, and could be inhibited by K + channel modulation ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Potassium Channels Inhibits Bunyavirus Infection

Hover

King

Hall

et al. 2016

Journal of Biological Chemistry

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Bunyaviruses are considered to be emerging pathogens facilitated by the segmented nature of their genome that allows reassortment between different species to generate novel viruses with altered pathogenicity. Bunyaviruses are transmitted via a diverse range of arthropod vectors, as well as rodents, and have established a global disease range with massive importance in healthcare, animal welfare, and economics. There are no vaccines or anti-viral therapies available to treat human bunyavirus infections and so development of new anti-viral strategies is urgently required. Bunyamwera virus (BUNV; genus Orthobunyavirus) is the model bunyavirus, sharing aspects of its molecular and cellular biology with all Bunyaviridae family members. Here, we show for the first time that BUNV activates and requires cellular potassium (K+) channels to infect cells. Time of addition assays using K+ channel modulating agents demonstrated that K+ channel function is critical to events shortly after virus entry but prior to viral RNA synthesis/replication. A similar K+ channel dependence was identified for other bunyaviruses namely Schmallenberg virus (Orthobunyavirus) as well as the more distantly related Hazara virus (Nairovirus). Using a rational pharmacological screening regimen, two-pore domain K+ channels (K2P) were identified as the K+ channel family mediating BUNV K+ channel dependence. As several K2P channel modulators are currently in clinical use, our work suggests they may represent a new and safe drug class for the treatment of potentially lethal bunyavirus disease.

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Section: Discussionmentioning

confidence: 99%

Modulation of Potassium Channels Inhibits Bunyavirus Infection

Hover

King

Hall

et al. 2016

Journal of Biological Chemistry

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“…Several strains cause diseases in domestic animals and are of veterinary concern. Infection can produce teratogenic effects, especially in ruminants (RODRIGUES HOFFMANN et al, 2013), and diseases of the CNS and abortions in horses (TAURO et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

Molecular survey of flaviviruses and orthobunyaviruses in Amblyomma spp. ticks collected in Minas Gerais, Brazil

Binder

Tauro

Farías

et al. 2019

Rev. Bras. Parasitol. Vet.

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Due to anthropic environmental changes, vector-borne diseases are emerging worldwide. Ticks are known vectors of several pathogens of concern among humans and animals. In recent decades, several examples of tick-borne emerging viral diseases have been reported (Crimean Congo hemorrhagic fever virus, Powassan virus, encephalitis virus, heartland virus, severe fever with thrombocytopenia syndrome virus). Unfortunately, few studies addressing the presence of viruses in wild ticks have been carried out in South America. With the aim of detecting flaviviruses and orthobunyaviruses in ticks, we carried out molecular detection in wild ticks collected in the state of Minas Gerais, Brazil. No Flavivirus-positive ticks were detected; however, we detected activity of Orthobunyavirus in 8 Amblyomma tick specimens. One of those individuals was positive for Bunyamwera orthobunyavirus, which represents the first report of this virus among ticks in South America. Further studies related to the ecology of zoonotic diseases are needed to increase knowledge of this topic, including attempts at viral isolation, full genome sequencing and biological characterization. In this way, we will obtain a better picture of the real risk of ticks as a vector for viral diseases for humans and animals on our continent, where no tick-borne viral disease is known to occur.

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“…BUNV is now considered endemic in several African countries, such as Uganda, Tanzania, Mozambique, Nigeria, Guinea, South Africa, and Democratic Republic of Congo (Figure 1 ). Recently, Cache Valley Fever virus was classified as a strain of BUNV, which expands the overall geographic range to North America, and additional strains of BUNV have been isolated in Argentina ( 2 ). A recent compilation of studies reported the presence of BUNV in Senegal, Guinea, Ivory Cost, Nigeria, Cameroon, Central African Republic, Kenya, Uganda, South Africa, and Madagascar ( 30 ).…”

Section: Origins and Geographic Distributions Of Bunv Batv And Nrivmentioning

confidence: 99%

“…Bunyamwera virus, BATV, and NRIV are etiological agents of diseases in humans and domestic animals. The disease associated with BUNV has been reported to cause mild symptoms, such as fever, joint pain, and rash in many mammals, including humans ( 2 , 12 – 14 ). BATV causes a mild flu-like illness in humans, is associated with a more severe disease in ruminants where it is manifested by abortions, premature births, and genetic defects ( 12 , 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

A Review of Bunyamwera, Batai, and Ngari Viruses: Understudied Orthobunyaviruses With Potential One Health Implications

Dutuze

Nzayirambaho

et al. 2018

Front. Vet. Sci.

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Bunyamwera (BUNV), Batai (BATV), and Ngari (NRIV) are mosquito-borne viruses of the Bunyamwera serogroup in the Orthobunyavirus genus of the Bunyaviridae family. These three viruses have been found to cause disease in both livestock animals, avian species, and humans. Thus, these viruses pose a potential threat to human public health, animal health, and food security. This is especially the case in the developing nations, where BUNV and NRIV are found, mainly in Africa. BUNV and BATV are fairly well characterized, while NRIV is not well characterized owing to only sporadic detection in human and animal populations in Africa. Reassortment is common among bunyaviruses, but NRIV is believed to be the only natural reassortant of the Bunyamwera serogroup. It resulted from a combination of BUNV S and L segments and the BATV M segment. This indicates at least some level co-circulation of BUNV and BATV, which have no historically been reported to overlap in geographic distributions. But as these viruses are undercharacterized, there remains a gap in the understanding of how such reassortment could occur, and the consequences of such. Due to their combined wide range of hosts and vectors, geographic distributions, potential severity of associated diseases, and potential for transmissibility between vertebrate hosts, these viruses represent a significant gap in knowledge with important One Health implications. The goal of this review is to report available knowledge of and identify potential future directions for study of these viruses. As these are collectively understudied viruses, there is a relative paucity of data; however, we use available studies to discuss different perspectives in an effort to promote a better understanding of these three viruses and the public and One Health threat(s) they may pose.

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First isolation of Bunyamwera virus (Bunyaviridae family) from horses with neurological disease and an abortion in Argentina

Cited by 34 publications

References 7 publications

Modulation of Potassium Channels Inhibits Bunyavirus Infection

Modulation of Potassium Channels Inhibits Bunyavirus Infection

Molecular survey of flaviviruses and orthobunyaviruses in Amblyomma spp. ticks collected in Minas Gerais, Brazil

A Review of Bunyamwera, Batai, and Ngari Viruses: Understudied Orthobunyaviruses With Potential One Health Implications

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