First isolation of MRSA ST398 from UK animals: a new challenge for infection control teams?

Loeffler, Anette; Kearns, Angela; Ellington, Matthew J.; Smith, Liz; Unt, V. E.; Lindsay, Jodi A.; Pfeiffer, Dirk U.; Lloyd, D. H.

doi:10.1016/j.jhin.2009.04.002

Cited by 44 publications

(38 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unlike in mainland Europe, this lineage has been less reported in the United Kingdom where it was first isolated in 2009 from horses 37 but, in the last few years, reports of isolation from United Kingdom dairy cattle, 38 poultry, 39 pigs, 40 and retail meat 41 have increased, suggesting that this lineage is becoming more common in the United Kingdom.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Livestock-Associated Methicillin-ResistantStaphylococcus aureusCC398 andmecC-positive CC130 from Zoo Animals in the United Kingdom

Bortolami

Verin

Chantrey

et al. 2017

Microbial Drug Resistance

View full text Add to dashboard Cite

Little is known about the characteristics and diseases associated with methicillin-resistant Staphylococcus aureus (MRSA) in nondomestic animals. Four presumptive MRSA isolates, obtained from clinical (n = 3) and surveillance specimens (n = 1) from dwarf (Helogale parvula) and yellow mongooses (Cynictis penicillata) from a United Kingdom zoo, were analyzed by PCR for detection of mecA and mecC-mediated methicillin resistance, and virulence genes. Isolates were genotyped by multilocus sequence typing (MLST) and staphylococcal cassette chromosome mec (SCCmec) and spa sequence typing. Three isolates, obtained from the dwarf mongooses, carried mecA, tetK, and fexA resistance and virulence genes (icaA, icaD, and sec) and were typed to SCCmec IVa, spa type t899, and clonal complex (CC) 398. The fourth MRSA isolate, obtained from the femoral bone marrow of a yellow mongoose showing postmortem findings consistent with septicemia, carried mecC and was oxacillin/cefoxitin susceptible, when tested at 37°C but showed a characteristic MRSA susceptibility profile at 25°C -2°C. Furthermore, this isolate exhibited a different genetic background (SCCmecXI/ t843/CC130) and had biofilm-associated genes (bap, icaA, and icaD) and tetK tetracycline resistance genes. This work describes the first isolation of livestock-associated MRSA CC398 from two zoo mongoose species where it was associated with both clinical disease and colonization, and the first isolation of mecC MRSA from a zoo species in the United Kingdom. Both reports highlight the potential for zoo species to act as reservoirs for these zoonotic agents.

show abstract

Section: Discussionmentioning

confidence: 99%

Characterization of Livestock-Associated Methicillin-ResistantStaphylococcus aureusCC398 andmecC-positive CC130 from Zoo Animals in the United Kingdom

Bortolami

Verin

Chantrey

et al. 2017

Microbial Drug Resistance

View full text Add to dashboard Cite

show abstract

“…MRSA strains isolated in most UK hospitals are identified as EMR-SA-15 (ST22) and EMRSA-16 (ST36) (Ellington et al, 2010) while the strains isolated in USA pets are the USA100 (ST5) which has been documented in HA-MRSA infections in humans (McDougal et al, 2003). In addition, a study in UK recovered MRSA clone (ST398) in dogs and horses that were characteristic of livestock animals (Loeffler et al, 2009). …”

Section: Mrsa In Companion Animalsmentioning

confidence: 99%

Methicillin Resistant Staphylococcus aureus (MRSA): A Review

Grema¹,

Geidam²,

Gadzama³

et al. 2015

Adv. Anim. Vet. Sci.

View full text Add to dashboard Cite

“…van Rijen et al [291] concluded in their report that the infection risk for pig and cow farmers (32%) is three times higher than for people who do not have direct contact with those animals. ST398 clones with SCCmecIV or V, as animal-associated CA-MRSA clones, have been widely spreading among livestock [269,[286][287][288][289][290]292] and companion animals (e.g., horses) [293]. ST398 clones were originally known as non-typeable MRSA in PFGE due to methylation of C-residues in the SmaI recognition site [294].…”

Section: Mrsa In Animalsmentioning

confidence: 99%

Community-acquired methicillin-resistant Staphylococcus aureus: community transmission, pathogenesis, and drug resistance

Yamamoto

Nishiyama

Takano

et al. 2010

Journal of Infection and Chemotherapy

135

167

View full text Add to dashboard Cite

Methicillin-resistant Staphylococcus aureus (MRSA) is able to persist not only in hospitals (with a high level of antimicrobial agent use) but also in the community (with a low level of antimicrobial agent use). The former is called hospital-acquired MRSA (HA-MRSA) and the latter community-acquired MRSA (CA-MRSA). It is believed MRSA clones are generated from S. aureus through insertion of the staphylococcal cassette chromosome mec (SCCmec), and outbreaks occur as they spread. Several worldwide and regional clones have been identified, and their epidemiological, clinical, and genetic characteristics have been described. CA-MRSA is likely able to survive in the community because of suitable SCCmec types (type IV or V), a clone-specific colonization/infection nature, toxin profiles (including Pantone-Valentine leucocidin, PVL), and narrow drug resistance patterns. CA-MRSA infections are generally seen in healthy children or young athletes, with unexpected cases of diseases, and also in elderly inpatients, occasionally surprising clinicians used to HA-MRSA infections. CA-MRSA spreads within families and close-contact groups or even through public transport, demonstrating transmission cores. Re-infection (including multifocal infection) frequently occurs, if the cores are not sought out and properly eradicated. Recently, attention has been given to CA-MRSA (USA300), which originated in the US, and is growing as HA-MRSA and also as a worldwide clone. CA-MRSA infection in influenza season has increasingly been noted as well. MRSA is also found in farm and companion animals, and has occasionally transferred to humans. As such, the epidemiological, clinical, and genetic behavior of CA-MRSA, a growing threat, is focused on in this study.

show abstract

First isolation of MRSA ST398 from UK animals: a new challenge for infection control teams?

Cited by 44 publications

References 7 publications

Characterization of Livestock-Associated Methicillin-ResistantStaphylococcus aureusCC398 andmecC-positive CC130 from Zoo Animals in the United Kingdom

Characterization of Livestock-Associated Methicillin-ResistantStaphylococcus aureusCC398 andmecC-positive CC130 from Zoo Animals in the United Kingdom

Methicillin Resistant Staphylococcus aureus (MRSA): A Review

Community-acquired methicillin-resistant Staphylococcus aureus: community transmission, pathogenesis, and drug resistance

Contact Info

Product

Resources

About