First-line drugs for hypertension

Wright, James M; Musini, Vijaya M; Gill, Rupam

doi:10.1002/14651858.cd001841.pub3

Cited by 235 publications

(103 citation statements)

References 210 publications

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“…It has been hypothesized that stroke patients admitted to the All India Institute of Medical Sciences (AIIMS), New Delhi, recently have a higher prevalence of hypertension as compared to those admitted before. This hypothesis was chosen keeping in mind that the cost-effective drug treatments for hypertension, hypercholesterolemia, and atrial fibrillation reduced stroke risk, heart disease, and mortality [7]. This hypothesis was based on the observations made by a senior neurologist.…”

Section: Introductionmentioning

confidence: 99%

Is Prevalence of Hypertension Increasing in First-Ever Stroke Patients?: A Hospital-Based Cross-Sectional Study

Pathak¹,

Kumar²,

Pandit³

et al. 2018

Ann Neurosci

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Background: Stroke is a devastating and disabling cerebrovascular disease with some amount of residual deficit leading to economic loss. Recent Indian studies have shown a stroke prevalence rate of 471.58/100,000 populations. Hypertension has been known to be the main risk factor for causing stroke. Purpose: To investigate the prevalence of hypertension in first-ever stroke patients and its comparison with the previous stroke registry. Methods: The study was a hospital-based cross-sectional study. Consecutive patients, who were admitted in the Neurology ward of All India Institute of Medical Sciences (AIIMS), New Delhi, India, were recruited for the study from the period July 2012 to January 2014. The stroke units consisted of a computerized record containing the details of all the admitted patients. Results: A total of 260 patients were recruited in which 194 (74.6%) were ischemic and 66 (25.4%) were hemorrhagic stroke patients. Hypertension was present in 169 (65%) patients. When compared with the previous stroke registry of 2,628 patients, hypertension was recorded in 1,503 (57.2%) patients. Conclusion: Our data show that there is an increase in the proportion of hypertension among first-ever stroke patients reported in AIIMS in the years 2012–2014 as compared to that reported in during the period 1998–2011.

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Section: Introductionmentioning

confidence: 99%

Is Prevalence of Hypertension Increasing in First-Ever Stroke Patients?: A Hospital-Based Cross-Sectional Study

Pathak¹,

Kumar²,

Pandit³

et al. 2018

Ann Neurosci

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show abstract

“…The review indicated that using thiazides as a first-line choice reduces coronary heart disease events compared with other classes. 9 ALLHAT showed that chlorthalidone was similarly effective in preventing coronary heart disease compared with doxazosin, lisinopril, and amlodipine, but chlorthalidone was more effective in preventing heart failure and stroke (than doxazosin or lisinopril only). Our study investigated effect modifications by sex.…”

mentioning

confidence: 99%

Comparative effectiveness of antihypertensive drugs in nondiabetic patients with hypertension: A population‐based study

Machado

Moura

Wang

et al. 2017

J of Clinical Hypertension

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“…A recent Cochrane review concluded that when used first-line for hypertension, CCBs prevented stroke and total cardiovascular syndromes, but not coronary heart disease or mortality (Wright, Musini, & Gill, 2018). The evidence was lowquality however, and it is important to consider that CCBs may also increase the risk of heart failure compared to diuretics, ACE inhibitors and ARBs (Chen et al, 2010).…”

Section: Mechanism Of Action Hypertensionmentioning

confidence: 99%

Use of calcium channel blockers in cardiovascular disease

Bain

2019

British Journal of Cardiac Nursing

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Calcium channel blockers (CCBs) are widely used agents in the management of a number of cardiovascular indications, including hypertension, angina and supraventricular tachycardias. By inhibiting the movement of calcium into the cytoplasm via transmembrane calcium channels, they reduce vascular and myocardial contractility, and modulate the activity of pacemaker cells. There are important differences between the different types of calcium channel blockers, and a sound understanding of their mechanism of action is required to promote their safe, effective use. This article briefly describes calcium channel pharmacology, the mechanism of action of CCBs and their place in the therapy of cardiovascular disease.

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First-line drugs for hypertension

Cited by 235 publications

References 210 publications

Is Prevalence of Hypertension Increasing in First-Ever Stroke Patients?: A Hospital-Based Cross-Sectional Study

Is Prevalence of Hypertension Increasing in First-Ever Stroke Patients?: A Hospital-Based Cross-Sectional Study

Comparative effectiveness of antihypertensive drugs in nondiabetic patients with hypertension: A population‐based study

Use of calcium channel blockers in cardiovascular disease

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