First molecular characterization of Escherichia coli O157:H7 isolates from clinical samples in Paraguay using whole-genome sequencing

Weiler, Natalia; Martínez, Lucia Jazmín; Campos, Josefina; Poklépovich, Tomás; Orrego, Maria; Ortiz, Flavia; Álvarez, Mercedes; Putzolu, Karina; Zolezzi, Gisela; Miliwebsky, Elisabeth; Chinen, Isao

doi:10.1016/j.ram.2022.11.002

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…The higher occurrence of Stx2 can be attributed to several factors, encompassing the biological characteristics of the toxins, variation in virulence, and genetic diversity of STEC strains. In this context, numerous studies have consistently suggested that stx2 gene is generally considered more virulent, potent and linked to more severe clinical outcomes than stx1 [ [44] , [45] , [46] ]. Additionally, STEC strains harboring the stx2 genes may possess a selective advantage concerning colonization or survival within the host [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular detection and antibiogram of Shiga toxin-producing Escherichia coli (STEC) from raw milk in and around Bahir Dar town dairy farms, Ethiopia

Yihunie,

Belete,

Fentahun

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Molecular detection and antibiogram of Shiga toxin-producing Escherichia coli (STEC) from raw milk in and around Bahir Dar town dairy farms, Ethiopia

Yihunie,

Belete,

Fentahun

et al. 2024

Heliyon

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Genomic Analysis of Pathogenic Escherichia coli Strains in Latin America

Chinen

Carbonari

Gustafson

et al. 2023

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Distributed genotyping and clustering of Neisseria strains reveal continual emergence of epidemic meningococcus over a century

Zhong,

Zhang,

Sun

et al. 2023

Nat Commun

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Core genome multilocus sequence typing (cgMLST) is commonly used to classify bacterial strains into different types, for taxonomical and epidemiological applications. However, cgMLST schemes require central databases for the nomenclature of new alleles and sequence types, which must be synchronized worldwide and involve increasingly intensive calculation and storage demands. Here, we describe a distributed cgMLST (dcgMLST) scheme that does not require a central database of allelic sequences and apply it to study evolutionary patterns of epidemic and endemic strains of the genus Neisseria. We classify 69,994 worldwide Neisseria strains into multi-level clusters that assign species, lineages, and local disease outbreaks. We divide Neisseria meningitidis into 168 endemic lineages and three epidemic lineages responsible for at least 9 epidemics in the past century. According to our analyses, the epidemic and endemic lineages experienced very different population dynamics in the past 100 years. Epidemic lineages repetitively emerged from endemic lineages, disseminated worldwide, and apparently disappeared rapidly afterward. We propose a stepwise model for the evolutionary trajectory of epidemic lineages in Neisseria, and expect that the development of similar dcgMLST schemes will facilitate epidemiological studies of other bacterial pathogens.

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First molecular characterization of Escherichia coli O157:H7 isolates from clinical samples in Paraguay using whole-genome sequencing

Cited by 3 publications

References 41 publications

Molecular detection and antibiogram of Shiga toxin-producing Escherichia coli (STEC) from raw milk in and around Bahir Dar town dairy farms, Ethiopia

Molecular detection and antibiogram of Shiga toxin-producing Escherichia coli (STEC) from raw milk in and around Bahir Dar town dairy farms, Ethiopia

Genomic Analysis of Pathogenic Escherichia coli Strains in Latin America

Distributed genotyping and clustering of Neisseria strains reveal continual emergence of epidemic meningococcus over a century

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