First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities

Karljiković‐Rajić, Katarina; Novovic, D.; Marinković, Valentina; Agbaba, Danica

doi:10.1016/s0731-7085(03)00204-8

Cited by 76 publications

(31 citation statements)

References 26 publications

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“…Several methods have been developed for determination, chiral separation, stability, or pharmacokinetic studies of 2 in bulk form, pharmaceuticals or biological samples, and these methods may include different spectrophotometric methods via formation of metal chelates [14], UV-derivative spectrophotometry [15] and HPLC methods for its determination [16], separation of enantiomers [17], for stability studies [18], or for the study of its pharmacokinetic profile [19].…”

Section: Introductionmentioning

confidence: 99%

Fluorometric Determination of Drugs Containing α-Methylene Sulfoxide Functional Groups Using - Methylnicotinamide Chloride as a Fluorogenic Agent

Elokely

Eldawy

Elkersh

et al. 2012

ISRN Analytical Chemistry

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A simple fluorometric method, using N 1 -methylnicotinamide chloride (NMNCl) as a fluorogenic reagent, has been developed, adapted, and validated for the quantitative estimation of drugs containing α-methylene sulfoxide functional groups. The proposed method has been applied successfully to the determination of sulindac (1), omeprazole (2), lansoprazole (3), pantoprazole (4), and rabeprazole (5) in the pure form, laboratory-prepared mixtures, pharmaceutical dosage forms, spiked human plasma samples, and in hospitalized patient's or volunteer's blood. For the standard solutions of 1, 2, 3, 4, and 5, the method showed linearity over concentration ranging between 1-50 μg/mL, 50-1200 ng/mL, 100-1500 ng/mL, 10-1500 ng/mL, and 20-2200 ng/mL, respectively. For the spiked human plasma of 1, 2, 3, 4, and 5, the linearity was shown over concentration ranging between 1-50 μg/mL, 75-1200 ng/mL, 100-1400 ng/mL, 10-1500 ng/mL, and 50-2100 ng/mL, respectively. The method showed good accuracy, specificity, and precision in both laboratory-prepared mixtures and spiked human plasma samples. The proposed method is simple, does not need sophisticated instrumentation, suitable for quality control application, bioavailability, and bioequivalency studies. Besides, the sensitivity and detection limits are comparable to sophisticated chromatographic methods.

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Section: Introductionmentioning

confidence: 99%

Fluorometric Determination of Drugs Containing α-Methylene Sulfoxide Functional Groups Using - Methylnicotinamide Chloride as a Fluorogenic Agent

Elokely

Eldawy

Elkersh

et al. 2012

ISRN Analytical Chemistry

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“…The characterization of impurities was based on the quantification of active ingredient content by nonspecific titrimetric [23] and photometric methods (such as UV spectroscopy [24], IR, Raman spectroscopy [25], and nuclear magnetic resonance [NMR] [26]), which were supported by the physical constants and some limit tests for known impurities. Even the pharmacopeias were suggesting various nonspecific characterization methods for determining the content of active ingredients.…”

Section: Conventional Approaches For the Isolation And Characterizatimentioning

confidence: 99%

Application of Liquid Chromatography Coupled With Mass Spectrometry in the Impurity Profiling of Drug Substances and Products

Akshatha

Gurupadayya

2018

Asian J Pharm Clin Res

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As the drug safety and efficacy is hampered in the presence of an impurity, the international regulatory agencies laid down stringent limits for the control of impurities in the active pharmaceutical ingredient and pharmaceutical formulations. The conventional approaches lack the characterization of impurities in trace levels, due to sensitivity issues, hyphenated techniques are preferred. Among the modern hyphenated techniques, liquid chromatography-mass spectrometry (LC-MS) has high sensitivity and can analyze large number of organic compounds in a short period of time. In the present study, the impurity profiling of various drug substances and products using LC-MS about past 6 years were retrospect for its importance, instrumentations, and applications.

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“…The different analytical techniques were reported so far for the determination of this drug along with corresponding impurities by UV-Visible spectrometry [9]- [12]. Several HPLC assay and LC-MS/MS method for determination of impurities and degradation products of Lansoprazole have been published [13]- [22].…”

Section: Introductionmentioning

confidence: 99%

Hydrolytic Degradation Study of Lansoprazole, Identification, Isolation and Characterisation of Base Degradation Product

Satyanarayana¹,

Pottabathini²

2015

AJAC

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Lansoprazole degradation is accelerated in both acidic and basic medium in water. The present investigation deals with the hydrolytic degradation of Lansoprazole. Acidic medium degradation show all known impurities and degradation products whereas basic degradation studies show new impurity which has higher molecular weight than Lansoprazole. New impurity was identified, isolated using mass based auto purification system and characterised by 1 H NMR, 13

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First-order UV-derivative spectrophotometry in the analysis of omeprazole and pantoprazole sodium salt and corresponding impurities

Cited by 76 publications

References 26 publications

Fluorometric Determination of Drugs Containing α-Methylene Sulfoxide Functional Groups Using - Methylnicotinamide Chloride as a Fluorogenic Agent

Fluorometric Determination of Drugs Containing α-Methylene Sulfoxide Functional Groups Using - Methylnicotinamide Chloride as a Fluorogenic Agent

Application of Liquid Chromatography Coupled With Mass Spectrometry in the Impurity Profiling of Drug Substances and Products

Hydrolytic Degradation Study of Lansoprazole, Identification, Isolation and Characterisation of Base Degradation Product

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