First Pediatric Case of Infective Endocarditis Caused by &lt;i&gt;Serratia Liquefaciens&lt;/i&gt;

Momose, Taichi; Masutani, Satoshi; Oshima, Ayumi; Kawasaki, Hidenori; Tanaka, Risa; Iwamoto, Yoichi; Ishido, Hirotaka; Senzaki, Hideaki

doi:10.1536/ihj.17-595

Cited by 12 publications

(5 citation statements)

References 6 publications

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“…Serratia spp. is one of such bacteria, which is a genus known to be pathogenic in many animals including insects (Chadwick et al, 1990 ; Ishii et al, 2014 ; Momose et al, 2018 ; Voirol et al, 2018 ). For example, the SM1 strain of S. marcescens was highly toxic to the black-winged termite, Odontotermes formosanus , probably through the production of insecticidal protease and metalloproteinases (Fu et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Mating Leads to a Decline in the Diversity of Symbiotic Microbiomes and Promiscuity Increased Pathogen Abundance in a Moth

Zhang

et al. 2022

Front. Microbiol.

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Mating may promote microbial diversity through sexual transmission, while mating-induced immune responses may decrease it. Therefore, the study of mating-induced microbiomes changes under different mating systems is informative to unravel its biological relevance and evolutionary significance. Here, we studied the microbiomes in a community context within the abdomen of Spodoptera frugiperda females using 16S rDNA sequences by setting virgin females, and females mated once, twice, or thrice with the same or different males. Alpha and beta diversities revealed that mating significantly affected the composition of microbiomes in S. frugiperda females, wherein virgin females have the highest diversity, followed by one-time mated females and females mated with multiple males, while females mated repeatedly with the same male showed the lowest diversity. The low diversity in females mated repeatedly with the same male may be due to lower sexual transmission as only mated with one mate and higher immune response from repeated matings. Functional prediction by FAPROTAX and literature searching found 17 possible pathogens and 12 beneficial microbiomes. Multiple mating turned over the abundance of pathogens and beneficial microbes, for example, Enterococcus and Lactobacillus spp. (beneficial) showed higher abundance in virgin females while Morganella and Serratia spp. (pathogens) showed higher abundance in females mated with multiple males. These results suggest that mating causes a decline in the diversity of symbiotic microbiomes and promiscuity incurs a higher pathogen abundance in S. frugiperda females, which may be the result of sexual transmission of bacterial strains and immune responses targeting members of the microbiomes. To our knowledge, we demonstrate microbiomes changes in female insects under virgin and different mating regimes for the first time.

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Section: Discussionmentioning

confidence: 99%

Mating Leads to a Decline in the Diversity of Symbiotic Microbiomes and Promiscuity Increased Pathogen Abundance in a Moth

Zhang

et al. 2022

Front. Microbiol.

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“…In humans, the few cases involved mainly hospital‐acquired infections such as pneumonia and urinary tract infection (Fitzgerald et al ; Serruys‐Schoutens et al ). Serratia liquefaciens has also been implicated in severe human infections, including infective endocarditis in infants (Momose et al ) and adults (Chuang et al ) as well as life‐threatening disease such as meningitis and septicaemia (Fitzgerald et al ). However, to our knowledge, this is the first documented detection of S. liquefaciens in commercial pigs.…”

Section: Resultsmentioning

confidence: 99%

First case of Serratia liquefaciens isolated from urinary tract infection in sows and associated clinicopathological and pathological findings

Papatsiros

Athanasiou

Spanou

et al. 2020

Lett Appl Microbiol

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An incident of sudden deaths in the breeding stock was reported from a farrow‐to‐finish commercial pig farm in Greece. The 8·4% of sows during lactation and gestation period presented anorexia, fever, haematuria, return‐to‐oestrus and sudden deaths (mortality rate: 2·3%). Blood and urine samples were collected from four diseased sows. Furthermore, swabs from urine bladders were collected from two dead sows and four culled sows at the slaughterhouse. Blood testing demonstrated mild leucocytosis and absence of azotaemia. Urinalysis revealed haematuria, proteinuria, bilirubinuria and active urine sediment with bacilli, epithelial cells and leucocytes, crystals and granular casts. Histopathological evaluation of the bladder demonstrated chronic active polypoid cystitis. The bacterial culture revealed the presence of Serratia liquefaciens. The antibiotic susceptibility testing showed high resistance to the most common antibiotics, with the highest sensitivity of the isolate towards quinolones. After the administration of a single dose of 7·5 mg kg−1 body weight enrofloxacin intramuscularly, the mortality rate decreased to less than 0·5% along with a remarkable reduction in the severity of clinical signs. Based on our findings, S. liquefaciens induced severe clinical signs and deaths in sows, mainly due to urinary infection. Inadequate water sanitation might have been responsible for increased exposure to S. liquefaciens. Significance and Impact of the Study In this study, the isolation of Serratia liquefaciens from the urinary tract of pigs associated with clinical signs and increased mortality was described for the first time. Serratia liquefaciens is an important cause of hospital‐acquired human infections. The isolate in this study was resistant to the most common antibiotics. Therefore, the use of quinolones which are drugs of last resort for treatment of infections was the only therapeutic option. The presence of the resistant bacterium in the urinary tract raises concerns for its zoonotic potential.

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“…Serratia liquefaciens is one of the opportunistic pathogens that widely exited in the environment and it is the major cause of Serratia infections which can lead bacteremia, respiratory tract infection, pneumonia and a series of other diseases [1,2]. In recent years, Serratia liquefaciens has developed high resistance to currently available antibiotics, such as Penicillin, and more and more multidrug-resistant strainswere also found [3,4].…”

Section: Main Textmentioning

confidence: 99%

Biological characterization and complete genome analysis of the newly isolated Serratia liquefaciens phage vB_SlqS_ZDD2

Zhao,

Han,

Chu

et al. 2024

Arch Virol

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First Pediatric Case of Infective Endocarditis Caused by <i>Serratia Liquefaciens</i>

Cited by 12 publications

References 6 publications

Mating Leads to a Decline in the Diversity of Symbiotic Microbiomes and Promiscuity Increased Pathogen Abundance in a Moth

Mating Leads to a Decline in the Diversity of Symbiotic Microbiomes and Promiscuity Increased Pathogen Abundance in a Moth

First case of Serratia liquefaciens isolated from urinary tract infection in sows and associated clinicopathological and pathological findings

Biological characterization and complete genome analysis of the newly isolated Serratia liquefaciens phage vB_SlqS_ZDD2

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