First Place — Student Research Award 1995: A Mechanism for Sympathectomy‐Induced Bone Resorption in the Middle Ear

Sherman, Bret E.; Chole, Richard A.

doi:10.1177/019459989511300508

Cited by 10 publications

(1 citation statement)

References 124 publications

(127 reference statements)

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“…Among sensory neuropeptides, CGRP has been found to inhibit bone resorption, suppress osteoclastogenesis and increase osteoblast proliferation [48][49][50]. SP has been found to be a potent bone resorptive factor, and its receptor, NK 1 , has been demonstrated in bone osteoblasts, osteocytes and osteoclasts [19,51,52]. Among autonomic neuropeptides, VIP-positive fibres have been detected preferentially in the epiphysis and periosteal regions of bone [53].…”

Section: Discussionmentioning

confidence: 99%

To investigate the role of the nervous system of bone in steroid-induced osteonecrosis in rabbits

Wang

et al. 2010

Osteoporos Int

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Section: Discussionmentioning

confidence: 99%

To investigate the role of the nervous system of bone in steroid-induced osteonecrosis in rabbits

Wang

et al. 2010

Osteoporos Int

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Bone Signaling in Middle Ear Development: A Genome‐Wide Differential Expression Analysis

Nielsen

Martin-Bertelsen

Friis

et al. 2014

The Anatomical Record

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Common middle ear diseases may affect bone behavior in the middle ear air cell system. To understand this pathologic pneumatization, the normal development of bone in the middle ear should be investigated. The objective of this study was to analyze gene expression of bone-related signaling factors and gene sets in the developing middle ear. Microarray technology was used to identify bone-related genes and gene sets, which were differentially expressed between the lining tissue of adult (quiescent) bulla and young (resorbing/forming) bulla. Data were analyzed using tools of bioinformatics and expression levels of selected genes were validated using quantitative polymerase chain reaction. The candidate gene products were compared with previously published data on middle ear bone metabolism. No differentially expressed genes were found on the outer surface of bulla. On the inner lining a total of 260 genes were identified of which 22 genes were involved in bone metabolism. Gene set analysis revealed five enriched bone-related gene sets. The identified differentially expressed bone-related mRNAs and gene sets are of potential significance in the normally developing bulla. These factors and gene sets may also play important roles during pathologic pneumatization of the middle ear air cell system in common middle ear diseases. In addition, this study suggests that the control of growth rate and wall thickness from resorptive as well as formative signals all originate from the inner lining cells of the bulla wall. Anat Rec, 297:2349Rec, 297: -2355

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Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats

Iwaniec

Boghossian

Trevisiol

et al. 2011

Journal of Bone and Mineral Research

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Hypothalamic leptin gene therapy normalizes the mosaic skeletal phenotype of leptin-deficient ob/ob mice. However, it is not clear whether increased hypothalamic leptin alters bone metabolism in animals already producing the hormone. The objective of this study was to evaluate the long duration effects of recombinant adeno-associated virus-rat leptin (rAAV-Lep) hypothalamic gene therapy on weight gain and bone metabolism in growing and skeletally mature leptin-replete female Sprague-Dawley rats. Rats were either unoperated or implanted with cannulae in the 3rd ventricle of the hypothalamus and injected with either rAAV-Lep or rAAV-GFP (control vector encoding green fluorescent protein) and maintained on standard rat chow fed ad lib for either 5 or 10 weeks (starting at 3 months of age) or 18 weeks (starting at 9 months of age). Tibiae, femora, or lumbar vertebrae were analyzed by microcomputed tomography and/or histomorphometry. In comparison to age-matched rAAV-GFP rats, rAAV-Lep rats maintained a lower body weight for the duration of studies. At 5 weeks post-vector administration, rAAV-Lep rats had lower cancellous bone volume and bone marrow adiposity but higher osteoblast perimeter compared to non-operated controls. However, these values did not differ between the two groups at 10 weeks post-vector administration. Differences in cancellous bone volume and architecture were not detected between the rAAV-Lep and rAAV-GFP groups at either time point. Also, rAAV-Lep had no negative effects on bone in the 9-month old skeletally mature rats at 18 weeks post-vector administration. We hypothesize that the transient reductions in bone mass and bone marrow adiposity at 5 weeks post-vector administration were due to hypothalamic surgery. We conclude that increased hypothalamic leptin, sufficient to prevent weight gain, has minimal specific effects (rAAV-Lep versus rAAV-GFP) on bone metabolism in normal female rats.

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First Place — Student Research Award 1995: A Mechanism for Sympathectomy‐Induced Bone Resorption in the Middle Ear

Cited by 10 publications

References 124 publications

To investigate the role of the nervous system of bone in steroid-induced osteonecrosis in rabbits

To investigate the role of the nervous system of bone in steroid-induced osteonecrosis in rabbits

Bone Signaling in Middle Ear Development: A Genome‐Wide Differential Expression Analysis

Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats

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