Micrambe tristis sp. nov., a new species of Cryptophagidae (Coleoptera), is described and illustrated from Eocene Danish amber. Micrambe tristis sp. nov. differs from M. sarnensis Lyubarsky et Perkovsky, 2010 from Baltic and Rovno amber by sutural stria present, size of pronotal callosity and length of antennomere 4. Extant species of subgenus are distributed on the highest mountains of Africa from southern Ethiopia to Tanzania. The supposed migration of the subgenus to Africa is discussed.