First report and molecular identification of Opisthorchis viverrini infection in human communities from Lower Myanmar

Aung, Win Pa Pa; Htoon, Thi Thi; Tin, Htay Htay; Thinn, Kyi Kyi; Sanpool, Oranuch; Jongthawin, Jurairat; Sadaow, Lakkhana; Phosuk, Issarapong; Rodpai, Rutchanee; Intapan, Pewpan M.; Maleewong, Wanchai

doi:10.1371/journal.pone.0177130

Cited by 59 publications

(47 citation statements)

References 27 publications

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“… 16 In Myanmar, O. viverrini infection was first reported in communities from lower Myanmar by Aung et al. 17 Their stool surveys of rural populations in three regions showed that the positive rate of Opisthorchis eggs was 9.30%. Our study is the second report of O. viverrini infection in humans from Myanmar, but is the first report on people from Myanmar who migrate to work in Thailand.…”

Section: Discussionmentioning

confidence: 99%

Active screening of gastrointestinal helminth infection in migrant workers in Thailand

et al. 2018

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ObjectiveThis study aimed to detect gastrointestinal helminth infection in migrant workers in Thailand.MethodsA cross-sectional survey study was conducted in 403 migrant workers in the factories of Nakhon Ratchasima Province, northeastern Thailand during October 2016 to June 2017. Gastrointestinal helminth infections were detected by the formalin ether acetate concentration technique and microscopy. The data were analyzed using the χ2-test and logistic regression.ResultsThe rate of gastrointestinal helminth infection was 24.07%. The most common species involved in infection was Opisthorchis viverrini (11.91%), followed by hookworm (5.46%), Trichuris trichiura (5.21%), Strongyloides stercoralis (0.5%), Ascaris lumbricoides (0.5%), and Taenia spp. (0.5%). The majority of infections were found in men aged ≥40 years, married participants, uneducated participants, laborers, those who worked for 1 year, and those who had an income of 9000 to 12,000 THB.ConclusionsGastrointestinal helminth infection is still found in migrant workers. Therefore, active surveillance is required in this large group for investigating and eradicating this type of infection.

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Section: Discussionmentioning

confidence: 99%

Active screening of gastrointestinal helminth infection in migrant workers in Thailand

et al. 2018

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“…O. viverrini sensu lato is found in those countries bordering the Lower Mekong River in continental Southeast Asia. It appears to be most frequent in Lao PDR, the north and northeast of Thailand, parts of Cambodia, and southern Vietnam ( 9 ), with a recent first record from Myanmar ( 10 ). Evidence suggests that its range is restricted to areas occupied by its first intermediate hosts, freshwater Bithynia snails ( 11 ) (Figure 1 ).…”

Section: Current Situationmentioning

confidence: 99%

Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia

et al. 2018

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Similar to bile duct cancer or cholangiocarcinoma (CCA) in the western world, opisthorchiasis-associated CCA in Southeast Asia is an aggressive cancer with high mortality rates. It is known to cause a significant health burden in the opisthorchiasis region in Thailand and possibly throughout mainland Southeast. To reduce this health burden, a comprehensive prevention and control program for opisthorchiasis, as well as CCA, is required. In this review, our aim is to provide a brief update of the current situation regarding the natural history of opisthorchiasis and health burden of CCA in Southeast Asia. A comprehensive approach to tackling these issues being implemented in Thailand under the “Cholangiocarcinoma Screening and Care Program” is described. This comprehensive program consists of a three stage prevention and patient care program. The primary prevention component involves opisthorchiasis screening using a new and sensitive urine assay. The secondary prevention component involves screening for CCA and periductal fibrosis, with suspected CCA patients following the protocol for confirmation and appropriate treatment. Due to the eco-epidemiology of opisthorchiasis-induced CCA, the anticipated impacts and outcomes of the program include short-, medium-, and the long-term goals for the reduction of CCA incidence. To achieve long-term sustainable impacts, concerted efforts to raise social awareness and participating action by general public, non-government organizations, and government agencies are necessary. The strategic plans developed for this program can be expanded for use in other endemic areas as well as being a model for use in other chronic diseases.

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“…1 Opisthorchis viverrini infection is a major public health problem in the Southeast Asian region, especially in regions along the drainage of the lower Mekong River-Cambodia, Lao People's Democratic Republic, southern Vietnam, Myanmar, and Thailand, where people have cultures and dietary preferences for consumption of raw or undercooked freshwater fishes that are contaminated with encysted metacercariae of the liver fluke. 1,5,6 More than 10 million people are estimated to be infected with O. viverrini: about eight million people in Thailand and two million in Lao PDR, with approximately 67.3 million people, are at risk of the infection. 1 Clonorchis sinensis is the main helminth causing a major public health problem in Northeast and East Asia (northern Vietnam, China, and Korea).…”

Section: Introductionmentioning

confidence: 99%

Development of an Immunochromatographic Point-of-Care Test for Serodiagnosis of Opisthorchiasis and Clonorchiasis

Sadaow

Sanpool

Rodpai

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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Chronic infections with the food-borne liver flukes, Opisthorchis viverrini or Clonorchis sinensis, associate with cholangiocarcinoma, bile duct cancer, which generally has a poor prognosis. We have produced a rapid and simple immunochromatographic test (ICT) kit for the diagnosis of opisthorchiasis and clonorchiasis by the detection of IgG antibodies in human infection sera. Sera from volunteers with proven opisthorchiasis and several other parasitic diseases and from healthy controls were evaluated for the presence of liver fluke infection-specific antibodies using a preparation of excretory-secretory antigen from adult stage O. viverrini absorbed onto ICT strips. Diagnostic values were compared with an ELISA. The diagnostic sensitivity, specificity, and positive and negative predictive values of the ELISA were 100%, 98.3%, 97.9%, and 100%, whereas those for the ICT were 94.6%, 91.2%, 89.7%, and 95.4%, respectively. There was 91.7% concordance between the ICT with ELISA, and differences in performance between the tests were not statistically significant (P > 0.05). Twenty-seven of 30 (90%) of the clonorchiasis sera also were positive by ICT. This new ICT provides a facile, rapid test for point-of-care testing tool, which can be used at the bedside without the need for sophisticated equipment. Moreover, the ICT can be anticipated to supplement stool examination as a screening tool in the clinic for the diagnosis of opisthorchiasis and clonorchiasis, and in addition, it may be useful in screens of populations at risk of liver fluke infection-associated cholangiocarcinoma.

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First report and molecular identification of Opisthorchis viverrini infection in human communities from Lower Myanmar

Cited by 59 publications

References 27 publications

Active screening of gastrointestinal helminth infection in migrant workers in Thailand

Active screening of gastrointestinal helminth infection in migrant workers in Thailand

Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia

Development of an Immunochromatographic Point-of-Care Test for Serodiagnosis of Opisthorchiasis and Clonorchiasis

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