First Report of Anthelmintic Resistance in Gastrointestinal Nematodes in Goats in Romania

Potârniche, Adrian Valentin; Mickiewicz, Marcin; Olah, Diana; Cerbu, Constantin; Spînu, Marina; Hari, Attila; Györke, Adriana; Moroz, Agata; Czopowicz, Michał; Várady, Marián; Kaba, Jarosław

doi:10.3390/ani11102761

Cited by 23 publications

(15 citation statements)

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“…The cross-sectional study conducted by Mickiewicz et al 9 revealed the presence of AR to BZ, ML, and LEV on Polish goat farms, in which the resistance is widespread to BZ and ML, while the resistance to LEV is at a low level. Potârniche et al 2 also reported the resistance of gastrointestinal nematodes against MLs and BZs, in goats in Romania, which is the first report in the country. In addition, isolated reports revealed the occurrence of helminth resistance to the most recent classes of anthelmintics (for instance, Haemonchus contortus has developed resistance to monepantel, C, and an aminoacetonitrile derivative).…”

Section: Anthelmintic Resistance and Its Mechanismmentioning

confidence: 89%

“…Sadly, application of anthelmintic drugs in an intensive way has led to a serious and dramatic level of anthelmintic resistance (AR), principally in cattle, sheep, goat, and equine gastrointestinal nematodes. 2 The increasing development of AR in parasites of livestock is threatening animal health and production worldwide. 3 Currently, there are three classes of anthelmintics most commonly used in small ruminants: the benzimidazoles (BZs), macrocyclic lactones (MLs) and cholinergic agonists (especially levamisole; LEV).…”

Section: Introductionmentioning

confidence: 99%

“…AR has been reported in all classes of anthelmintics. 2 The time that the development of resistance against an anthelmintic drug from its introduction looks like less than 10 years. 4 …”

Section: Introductionmentioning

confidence: 99%

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Anthelmintic Resistance and Its Mechanism: A Review

Fissiha¹,

Kinde²

2021

IDR

118

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Helminths are a various types of parasites causing a major health problem for animals in different parts of the globe. Control of helminthiasis has largely relied on the use of pharmaceutical anthelmintics. Unfortunately, the exhaustive use of anthelmintic drugs has led to a serious and dramatic level of anthelmintic resistance. Anthelmintic resistance is a heritable loss of sensitivity of an anthelmintic in a parasite population that was in the past susceptible to the same anthelmintic. The development of anthelmintic resistance is evident to different helminths of almost every animal species and to different groups of anthelmintic in several continents. Frequent treatment, underdosing, genetics of the parasite, and targeting and timing of mass treatment are predisposing factors for anthelmintic resistance. Upregulation of cellular efflux mechanisms, an increase in drug metabolism, a change in drug receptor sites that reduces drug binding or the functional consequences of drug binding, and a decrease in drug receptor abundance through reduced expression within the parasite are the main mechanisms of anthelmintic resistance. In vivo method like fecal egg count reduction test and in vitro method such as egg hatch assays, larval motility test, larval development test and PCR can be used for the detection of anthelmintic resistance. Proper utilization of anthelmintic drugs, using combined anthelmintic and applying other alternatives are essential strategies to slow down the development of anthelmintic resistance. As anthelmintic resistance is a serious challenge throughout the world, proper utilization of the existing anthelmintics and reducing dependence on anthelmintics should be implemented to reduce its challenge.

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Section: Anthelmintic Resistance and Its Mechanismmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Anthelmintic Resistance and Its Mechanism: A Review

Fissiha¹,

Kinde²

2021

IDR

118

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“…However, the long-term sustainability of routine anthelmintic treatment is challenged by accelerating development of drug resistance in small ruminant parasites ( 6 , 7 ). GIT parasites have been shown to develop resistance to anthelmintic drugs following repeated use of the same anthelmintic over time, particularly for certain parasite species and drug classes such as benzimidazoles ( 8 ). Over time, these resistant organisms will dominate the parasite population and jeopardize efforts to control worm burden ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…Routine anthelmintic treatment of small ruminants to control gastrointestinal tract (GIT) parasites is a recommended and accepted management practice to maintain and improve animal health and performance. However, the long-term sustainability of routine anthelmintic treatment is challenged by accelerating development of drug resistance in small ruminant parasites (6,7). GIT parasites have been shown to develop resistance to anthelmintic drugs following repeated use of the same anthelmintic over time, particularly for certain parasite species and drug classes such as benzimidazoles (8).…”

Section: Introductionmentioning

confidence: 99%

Ovine gastrointestinal parasite burden and the impact of strategic anthelmintic treatment in community-based breeding sites in Ethiopia

Molla

Moliso²,

Gizaw³

et al. 2023

Front. Vet. Sci.

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IntroductionIn Ethiopia, small ruminants contribute significantly to livelihoods and food security but productivity is low with high disease burden and essential endoparasite control not widely practiced. The current study assessed worm burden and its control in three districts in Ethiopia.MethodsAll sheep older than 3 months in nine villages were treated en-masse with albendazole and triclabendazole twice a year from 2018 to 2021. Treatments were administered under field conditions by animal health workers. Pre- and post-treatment data were assessed looking at fecal egg presence/absence and fecal egg per gram (EPG) count.ResultsA total of 1,928 and 735 sheep were examined before and after deworming, respectively. Before treatment worms were detected in 54.4% (95% CI: 52.2–56.6) of sheep. Strongylid (30.4%) and Fasciola (18.2%) were the most frequently identified parasites. Animals living in wet mid-highland environments were more than 23 times more likely to have strongylid eggs in their feces and 5 times more likely to have eggs from any gastrointestinal tract (GIT) parasites detected, as compared to animals living in moist highland agro-ecology. Over the course of the 2018–2021 community intervention there was total elimination of animals with a high worm burden (EPG > 1,500), and elimination of a third of those with moderate infections. Mild infections remained, largely accounted for by strongylid, which remains at low levels in healthy sheep. However, there were signs of emerging drug resistance.ConclusionGenerally, sheep in smallholder systems in Ethiopia experience a needlessly large economic burden from GIT worms. Routine therapy reduces this burden but smart strategies are needed to limit the onset of drug resistance.

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