First report of autochthonous canine leishmaniasis caused by Leishmania (L.) mexicana in Sinaloa, Mexico

Castillo-Ureta, Hipólito; Zazueta-Moreno, José Marcial; Rendón-Maldonado, José Guadalupe; Torres-Avendaño, José Israel; López-Moreno, Héctor Samuel; Olimón-Andalón, Vicente; Salomón-Soto, Víctor Manuel; Pérez-Sánchez, Fabiola Patricia; Torres-Montoya, Edith Hilario

doi:10.1016/j.actatropica.2018.11.027

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…In contrast to the visceral form (CanL), autochthonous canine cutaneous cases have been reported within the U.S. sand flies in Texas and Mexico have transmitted L. mexicana to dogs and cats (Fig. 1 ) [ 58 – 61 ]. Additionally, an equine cutaneous case of L. siamensis infection was diagnosed in a Morgan mare in Florida with no international travel history (Fig.…”

Section: Disease Manifestations and Implicationsmentioning

confidence: 99%

Possibility of Leishmania Transmission via Lutzomyia spp. Sand Flies Within the USA and Implications for Human and Canine Autochthonous Infection

2022

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Purpose of Review Leishmaniasis is a leading cause of parasitic death, with incidence rising from decreased resources to administer insecticide and anti-leishmanial treatments due to the COVID-19 pandemic. Leishmaniasis is nonendemic in the United States (U.S.), but enzootic canine populations and potentially competent vectors warrant monitoring of autochthonous disease as a fluctuating climate facilitates vector expansion. Recent studies concerning sand fly distribution and vector capacity were assessed for implications of autochthonous transmission within the U.S. Recent Findings Climate change and insecticide resistance provide challenges in sand fly control. While most Leishmania -infected dogs in the U.S. were infected via vertical transmission or were imported, autochthonous vector-borne cases were reported. Autochthonous vector-borne human cases have been reported in four states. Further vaccine research could contribute to infection control. Summary Both cutaneous and visceral leishmaniasis cases in the U.S. are increasingly reported. Prevention measures including vector control and responsible animal breeding are critical to halt this zoonotic disease.

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Section: Disease Manifestations and Implicationsmentioning

confidence: 99%

Possibility of Leishmania Transmission via Lutzomyia spp. Sand Flies Within the USA and Implications for Human and Canine Autochthonous Infection

2022

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“…There are over 2 million new cases of leishmaniasis per year, with approximately 400 million people at risk worldwide. It is also one of the most prevalent causes of death and animal morbidity in endemic area of underdeveloped countries [2,3]. Leishmaniasis has different clinical manifestations, including cutaneous, mucocutaneous, diffuse cutaneous, viscera and post kala-azar dermal leishmaniasis [4,5].…”

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confidence: 99%

A Novel Anti-Microbial Peptide from Pseudomonas, REDLK Induced Growth Inhibition of Leishmania tarentolae Promastigote In Vitro

Zhao

Cao

et al. 2020

Korean J Parasitol

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Leishmaniasis is a prevalent cause of death and animal morbidity in underdeveloped countries of endemic area. However, there is few vaccine and effective drugs. Antimicrobial peptides are involved in the innate immune response in many organisms and are being developed as novel drugs against parasitic infections. In the present study, we synthesized a 5-amino acid peptide REDLK, which mutated the C-terminus of Pseudomonas exotoxin, to identify its effect on the Leishmania tarentolae. Promastigotes were incubated with different concentration of REDLK peptide, and the viability of parasite was assessed using MTT and Trypan blue dye. Morphologic damage of Leishmania was analyzed by light and electron microscopy. Cellular apoptosis was observed using the annexin V-FITC/PI apoptosis detection kit, mitochondrial membrane potential assay kit and flow cytometry. Our results showed that Leishmania tarentolae was susceptible to REDLK in a dose-dependent manner, disrupt the surface membrane integrity and caused parasite apoptosis. In our study, we demonstrated the leishmanicidal activity of an antimicrobial peptide REDLK from Pseudomonas aeruginosa against Leishmania tarentolae in vitro and present a foundation for further research of anti-leishmanial drugs.

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Is leishmaniasis the new emerging zoonosis in the world?

Montaner-Angoiti

Llobat

2023

Vet Res Commun

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First report of autochthonous canine leishmaniasis caused by Leishmania (L.) mexicana in Sinaloa, Mexico

Cited by 6 publications

References 14 publications

Possibility of Leishmania Transmission via Lutzomyia spp. Sand Flies Within the USA and Implications for Human and Canine Autochthonous Infection

Possibility of Leishmania Transmission via Lutzomyia spp. Sand Flies Within the USA and Implications for Human and Canine Autochthonous Infection

A Novel Anti-Microbial Peptide from Pseudomonas, REDLK Induced Growth Inhibition of Leishmania tarentolae Promastigote In Vitro

Is leishmaniasis the new emerging zoonosis in the world?

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