First report of Borrelia burgdorferi sensu stricto detection in a commune genospecies in Apodemus agrarius in Gwangju, South Korea

Kim, Choon Mee; Park, So Young; Kim, Dong-Min; Park, Jung–Wook; Chung, Jae Keun

doi:10.1038/s41598-021-97411-3

Cited by 5 publications

(7 citation statements)

References 32 publications

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“…In this study, only B. afzelii was detected, but previous studies confirmed B. garinii, which is known to be pathogenic to humans, similar to B. afzelii. A recent study in which B. afzelii and B. garinii was detected in wild rodent tissues showed that the Borrelia-positive rate was 29.8% and 25.9% for B. afzelii and 3.7% for B. garinii [10]. Another study identified Borrelia genospecies in various sampling areas in Korea, which were identified as B. afzelii (62.5%) and B. garinii (1.6%) [7].…”

Section: Discussionmentioning

confidence: 99%

“…The incidence has increased since then [4,7]. In Korea, on average, 15.4 cases per year have been reported in the past decade, with 23 cases reported in 2019 and 18 cases reported in 2020 [9,10]. In Korea, research on Borrelia is currently being carried out on the pathogenicity of various wild animals, including ticks, rodents, and companion animals [3,7,[11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, some were found only in Jeju Island (B. yangtzensis and B. tanukii) [7]. Recently, B. burgdorferi sensu stricto, known to cause Lyme borreliosis in northern America, has been identified for the first time in Korea [10].…”

Section: Introductionmentioning

confidence: 99%

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Molecular Identification of Borrelia spp. from Ticks in Pastures Nearby Livestock Farms in Korea

Lee

Shin

et al. 2021

Insects

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Ticks are vectors that spread pathogenic bacteria, viruses, and protozoa. As the number of ticks increases due to climate change, the importance of the study of tick-borne pathogens has also increased. This study was conducted to investigate the distribution of the major tick species causing Lyme borreliosis and regional differences in the prevalence of Borrelia spp. by tick species. Borrelia infection was confirmed not only in Ixodes ticks, which are the major vectors of Borrelia spp., but also in Haemaphysalis and Amblyomma ticks. PCR targeting the 5S-23S rRNA intergenic spacer region (rrf-rrl) was performed to confirm Borrelia positivity. A total of 6102 ticks (736 pools) were tested, and the proportion was Haemaphysalis longicornis nymphs and adults at 69.2%, Haemaphysalis flava nymphs and adults at 13.9%, Haemaphysalis spp. larva at 14.3%, Ixodes nipponensis at 0.8%, and Amblyomma testudinarium at 1.9%. Ixodes nipponensis showed the highest minimum infection rate (MIR: 34.00; 17 pools/50 ticks) for Borrelia spp., followed by A. testudinarium (MIR: 0.88), and H. longicornis (MIR: 0.05). In particular, to our knowledge Borrelia infection was first confirmed in A. testudinarium in Korea. As a result of phylogenetic analysis, all sequences were grouped with Borreliaafzelii isolates and showed a close relationship with high identity. Considering that B. afzelii causes infectious zoonotic diseases, continuous monitoring and attention are needed, although it has a low prevalence in this study.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecular Identification of Borrelia spp. from Ticks in Pastures Nearby Livestock Farms in Korea

Lee

Shin

et al. 2021

Insects

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“…Water deer (Hydropotes inermis Swinho, 1870) comprise two subspecies: H. inermis inermis in the eastern region of China and H. inermis argyropus across South Korea, listed as vulnerable on the International Union for Conservation of Nature (IUCN) Red List [19]. In China, H. inermis inermis faces declining numbers due to habitat loss and fragmentation, whereas H. inermis argyropus thrives throughout South Korea, where its ecosystem lacks natural predators [20][21][22][23]. A generalist species, water deer adeptly inhabit croplands, wetlands, grasslands, and forests [23], displaying edge species characteristics [19].…”

Section: Introductionmentioning

confidence: 99%

Parasitic Characteristics of Ticks (Acari: Ixodidae) Collected from Water Deer (Hydropotes inermis argyropus) and Spatiotemporal Distribution Prediction within Host-Influenced Cultivated Areas

Kim,

Yoon

et al. 2024

Animals

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Tick-borne diseases result from human–ixodid tick encounters, making it crucial to understand host–ixodid tick interactions and host-dependent distribution for epidemiology and prevention. This study examines water deer patterns and ixodid tick interactions in designated croplands of South Korea over two years, finding that the highest deer presence occurred in July and the lowest in May, during crop harvesting. Four tick species were identified, with Haemaphysalis longicornis being predominant (92.2%). Tick life stage analysis revealed peak nymphs and adults in July and larvae in October. Nymph abundance correlated positively with nearby water deer. MaxEnt biodiversity prediction results indicated wider water deer distribution in summer, reflecting their tendency to use multiple croplands. Areas with nymphs and adults aligned with predicted deer presence in summer, while larval areas aligned in autumn. Increased agroforestry expanded water deer habitats, enhancing tick dispersion. Prevention involved minimizing human–deer encounters by strategic land use in tick-prone areas. This comprehensive study provides insights into preventing severe fever with thrombocytopenia syndrome in agricultural workers, emphasizing the need for targeted interventions based on host behavior and tick life stages in different seasons.

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“…burgdorferi s.l. was first detected in 1993 and has been sporadically identified in ticks, dogs, horses, wild rodents, and humans [ 51 – 56 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular surveillance of zoonotic pathogens from wild rodents in the Republic of Korea

Choi,

Hwang,

Kim

et al. 2024

PLoS Negl Trop Dis

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Background Rodents are recognized as major reservoirs of numerous zoonotic pathogens and are involved in the transmission and maintenance of infectious diseases. Furthermore, despite their importance, diseases transmitted by rodents have been neglected. To date, there have been limited epidemiological studies on rodents, and information regarding their involvement in infectious diseases in the Republic of Korea (ROK) is still scarce. Methodology/Principal findings We investigated rodent-borne pathogens using nested PCR/RT-PCR from 156 rodents including 151 Apodemus agrarius and 5 Rattus norvegicus from 27 regions in eight provinces across the ROK between March 2019 and November 2020. Spleen, kidney, and blood samples were used to detect Anaplasma phagocytophilum, Bartonella spp., Borrelia burgdorferi sensu lato group, Coxiella burnetii, Leptospira interrogans, and severe fever with thrombocytopenia syndrome virus (SFTSV). Of the 156 rodents, 73 (46.8%) were infected with Bartonella spp., 25 (16.0%) with C. burnetii, 24 (15.4%) with L. interrogans, 21 (13.5%) with A. phagocytophilum, 9 (5.8%) with SFTSV, and 5 (3.2%) with Borrelia afzelii. Co-infections with two and three pathogens were detected in 33 (21.1%) and 11 rodents (7.1%), respectively. A. phagocytophilum was detected in all regions, showing a widespread occurrence in the ROK. The infection rates of Bartonella spp. were 83.3% for B. grahamii and 16.7% for B. taylorii. Conclusions/Significance To the best of our knowledge, this is the first report of C. burnetii and SFTSV infections in rodents in the ROK. This study also provides the first description of various rodent-borne pathogens through an extensive epidemiological survey in the ROK. These results suggest that rodents harbor various pathogens that pose a potential threat to public health in the ROK. Our findings provide useful information on the occurrence and distribution of zoonotic pathogens disseminated among rodents and emphasize the urgent need for rapid diagnosis, prevention, and control strategies for these zoonotic diseases.

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First report of Borrelia burgdorferi sensu stricto detection in a commune genospecies in Apodemus agrarius in Gwangju, South Korea

Cited by 5 publications

References 32 publications

Molecular Identification of Borrelia spp. from Ticks in Pastures Nearby Livestock Farms in Korea

Molecular Identification of Borrelia spp. from Ticks in Pastures Nearby Livestock Farms in Korea

Parasitic Characteristics of Ticks (Acari: Ixodidae) Collected from Water Deer (Hydropotes inermis argyropus) and Spatiotemporal Distribution Prediction within Host-Influenced Cultivated Areas

Molecular surveillance of zoonotic pathogens from wild rodents in the Republic of Korea

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