First report of carbapenem-resistant Providencia stuartii in Saudi Arabia

Abdallah, Mohammad; Alhababi, R.; Alqudah, Noor; Aldyyat, B.; Alharthy, Abdurahman

doi:10.1016/j.nmni.2018.09.007

Cited by 16 publications

(14 citation statements)

References 10 publications

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“…Potential endogenous infectious with P. Stuartii was detected from tracheal aspirates, urine, and blood. P. Stuartii is among the most common causes of nosocomial urinary tract infections, pneumonia, and wound and bloodstream infections that end with severe patients' outcomes [73][74][75]. P. Stuartii survives well in natural environment and often causes opportunistic infection in residents of long-term care facilities (LTCFs).…”

Section: Discussionmentioning

confidence: 99%

A Multi-Point Surveillance for Antimicrobial Resistance Profiles among Clinical Isolates of Gram-Negative Bacteria Recovered from Major Ha’il Hospitals, Saudi Arabia

et al. 2021

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The devastating nosocomial resistance is an on-going global concern. Surveillance of resistance is crucial for efficient patient care. This study was aimed to conduct a surveillance in four major Ha’il Hospitals from September to December 2020. Using a multipoint program, records of 621 non-duplicate Gram-negative cultures were tested across 21 drugs belonging to different categories. Major species were Klebsiella pneumoniae (n = 187, 30%), E. coli (n = 151, 24.5%), Pseudomonas aeruginosa, (n = 84, 13.6%), Acinetobacter baumannii (n = 82, 13.3%), and Proteus mirabilis (n = 46, 7%). Based on recent resistance classifications, A. baumanni, P. aeruginosa, and enteric bacteria were defined as pan-resistant, extremely resistant, and multi-drug resistant, respectively. A. baumannii (35%) and K. pneumoniae (23%) dominated among coinfections in SARS-CoV2 patients. The “other Gram-negative bacteria” (n = 77, 12.5%) from diverse sources showed unique species-specific resistance patterns, while sharing a common Gram-negative resistance profile. Among these, Providencia stuartii was reported for the first time in Ha’il. In addition, specimen source, age, and gender differences played significant roles in susceptibility. Overall infection rates were 30% in ICU, 17.5% in medical wards, and 13.5% in COVID-19 zones, mostly in male (59%) senior (54%) patients. In ICU, infections were caused by P. mirabilis (52%), A. baumannii (49%), P. aeruginosa (41%), K. pneumoniae (24%), and E. coli (21%), and most of the respiratory infections were caused by carbapenem-resistant A. baumannii and K. pneumoniae and UTI by K. pneumoniae and E. coli. While impressive IC, hospital performances, and alternative treatment options still exist, the spread of resistant Gram-negative bacteria is concerning especially in geriatric patients. The high selective SARS-CoV2 coinfection by A. baumannii and K. pneumoniae, unlike the low global rates, warrants further vertical studies. Attributes of resistances are multifactorial in Saudi Arabia because of its global partnership as the largest economic and pilgrimage hub with close social and cultural ties in the region, especially during conflicts and political unrests. However, introduction of advanced inter-laboratory networks for genome-based surveillances is expected to reduce nosocomial resistances.

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Section: Discussionmentioning

confidence: 99%

A Multi-Point Surveillance for Antimicrobial Resistance Profiles among Clinical Isolates of Gram-Negative Bacteria Recovered from Major Ha’il Hospitals, Saudi Arabia

et al. 2021

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“… 1 Notably, P. stuartii is a rare opportunistic organism that causes healthcare-associated infections, such as acute enteric infection, urinary tract infection, and lung diseases. 2 The organism is typically isolated from human secretions, including urine, sputum, blood, stool, and wound cultures. The treatment of choice is based on antibiotic sensitivities, infection source, and comorbid conditions.…”

Section: Introductionmentioning

confidence: 99%

Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients

2020

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Objectives To investigate the clinical and drug resistance characteristics of Providencia stuartii infections in the Huainan region of Anhui and provide a reference for the clinical selection of antimicrobial agents. Methods This single-center retrospective analysis included 76 patients with P. stuartii infection in Huainan during the period from October 2018 to March 2020. The hospital department in which the patients were treated and the drug susceptibility characteristics of the P. stuartii isolates were recorded. Results Among the 76 patients, the lung was the most common site of infection, and intensive care unit was the main hospital department. Extended spectrum beta-lactamase screening revealed expression by all 76 isolates of P. stuartii. Of the 76 isolates, 92.1% exhibited multiple drug resistance or extensive drug resistance. P. stuartii isolates were sensitive to cefepime and imipenem, but not to other beta-lactam antibiotics. Twenty isolates were resistant to all 21 types of antibiotics. Of the 20 patients infected with extensively drug-resistant isolates, nine (45%) died. Conclusions Drug resistance is increasing in P. stuartii. The antimicrobial agent imipenem may be effective for treatment of P. stuartii infections. Fluoroquinolones, aminoglycosides, and fourth-generation cephalosporins are suitable options for antibiotic therapy.

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“…It displays intrinsic resistance to polymyxins, nitrofurans, sulfamethoxazole, tetracyclines, fluoroquinolones, and aminoglycosides ( 3 ). Outbreaks of carbapenem-resistant P. stuartii have been reported in intensive care units in Brazil ( 4 ), Greece ( 5 ), and Saudi Arabia ( 6 ). Here, we present the draft genome sequence of the first New Delhi metallo-β-lactamase (NDM-1)-positive P. stuartii isolate reported in Peru.…”

Section: Announcementmentioning

confidence: 99%

mentioning

confidence: 99%

Draft Genome Sequence of a New Delhi Metallo-β-Lactamase (NDM-1)-Producing Providencia stuartii Strain Isolated in Lima, Peru

Lezameta

Cuicapuza

Dávila-Barclay

et al. 2020

Microbiol Resour Announc

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First report of carbapenem-resistant Providencia stuartii in Saudi Arabia

Cited by 16 publications

References 10 publications

A Multi-Point Surveillance for Antimicrobial Resistance Profiles among Clinical Isolates of Gram-Negative Bacteria Recovered from Major Ha’il Hospitals, Saudi Arabia

A Multi-Point Surveillance for Antimicrobial Resistance Profiles among Clinical Isolates of Gram-Negative Bacteria Recovered from Major Ha’il Hospitals, Saudi Arabia

Clinical and drug resistance characteristics of Providencia stuartii infections in 76 patients

Draft Genome Sequence of a New Delhi Metallo-β-Lactamase (NDM-1)-Producing Providencia stuartii Strain Isolated in Lima, Peru

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