First Report of Extended-Spectrum-β-Lactamase-Producing
            <i>Salmonella enterica</i>
            Serovar Kentucky Isolated from Poultry in Ireland

Boyle, F.; Morris, Dearbháile; O’Connor, Jacqueline; DeLappe, Niall; Ward, J. L.; Cormican, Martin

doi:10.1128/aac.00916-09

Cited by 27 publications

(26 citation statements)

References 20 publications

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“…CTX-M-15, the ESBL considered to have spread in a pandemic fashion in humans, was only detected incidentally in food-producing animals or food and in only in a few countries in E. coli (isolated in France from diseased cattle, in Belgium from healthy poultry, and in UK in broiler chickens and turkey) and in Salmonella isolates (Germany, one S. Typhimurium from horse origin) (Madec et al, 2008;Randall et al, 2011;Rodriguez et al, 2009;Smet et al, 2008). ESBLs of the SHV class were frequently detected throughout the EU, especially SHV-12 and SHV-2 Bortolaia et al, 2010b;Boyle et al, 2010;Brinas et al, 2003a;Brinas et al, 2003b;Chiaretto et al, 2008;Cortes et al, 2010;Costa et al, 2009;Dierikx et al, 2010a;Doi et al, 2009;Escudero et al, 2010;Goncalves et al, 2010;Hasman et al, 2005;Hopkins et al, 2006;Kolar et al, 2010;Machado et al, 2008;Madec et al, 2008;Morris et al, 2009;Riano et al, 2006). In relation to the ESBLs of the TEM class, the most frequently detected throughout the EU was TEM-52 Brinas et al, 2005;Carneiro et al, 2010;Cloeckaert et al, 2007;Costa et al, 2009;Dierikx et al, 2010a;Jensen et al, 2006;Machado et al, 2008;Morris et al, 2009;Randall et al, 2011;Rodriguez et al, 2009;Smet et al, 2008).…”

Section: Esbl-subtypes Detected In E Coli and Salmonella From Food-pmentioning

confidence: 99%

“…In relation to the ESBLs of the TEM class, the most frequently detected throughout the EU was TEM-52 Brinas et al, 2005;Carneiro et al, 2010;Cloeckaert et al, 2007;Costa et al, 2009;Dierikx et al, 2010a;Jensen et al, 2006;Machado et al, 2008;Morris et al, 2009;Randall et al, 2011;Rodriguez et al, 2009;Smet et al, 2008). To a lesser extend TEM-20 was detected in countries as Netherlands, Ireland and Germany (Boyle et al, 2010;Dierikx et al, 2010a;Hasman et al, 2005;Hopkins et al, 2006;Rodriguez et al, 2009). …”

Section: Esbl-subtypes Detected In E Coli and Salmonella From Food-pmentioning

confidence: 99%

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Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

2011

EFSA Journal

246

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The potential contribution of food-producing animals or foods to public health risks by ESBL and/or AmpCproducing bacteria is related to specific plasmid-mediated ESBL and/or AmpC genes encoded by a number of organisms. The predominant ESBL families encountered are CTX-M, TEM, and SHV; the predominant AmpCfamily is CMY. The most common genes associated with this resistance in animals are bla CTX-M-1 (the most commonly identified ESBL), and bla CTX-M-14 , followed by bla and bla Among the genes encoding AmpC-type β-lactamases, bla CMY-2 is the most common.The bacterial species most commonly identified with these genes are Escherichia coli and non-typhoidal Salmonella. ESBL/AmpC transmission is mainly driven by integrons, insertion sequences, transposons and plasmids, some of which are homologous in isolates from both food-production animals and humans. Cefotaxime is used as the drug of choice for optimum detection of bla ESBL and/or bla AmpC genes. The preferred method for isolation of ESBL-and/or AmpC-producers is screening on selective agar preceded by selective enrichment in a broth.The establishment of risk factors for occurrence of ESBL/AmpC-producing bacteria is particularly complicated by the data unavailability or lack of its accuracy. The use of antimicrobials is a risk factor for the selection and spread of resistant clones, resistance genes and plasmids. Since most ESBL-and AmpC-producing strains carry additional resistances to other commonly-used veterinary drugs, generic antimicrobial use is a risk factor for ESBL/AmpC and it is not restricted specifically to the use of cephalosporins. An additional risk factor is extensive trade of animals in EU MS. There are no data on the comparative efficiency of individual control options in reducing public health risks caused by ESBL and/or AmpC-producing bacteria related to food-producing animals. Prioritisation is complex, but it is considered that a highly effective control option would be to stop all uses of cephalosporins/systemically active 3 rd /4 th generation cephalosporins, or to restrict their use (use only allowed under specific circumstances). As co-resistance is an important issue, it is also of high priority to decrease the total antimicrobial use in animal production in the EU. KEY WORDSResistance, ESBLs, AmpC, occurrence, transmission, control options, public health microbiology. SUMMARYFollowing a request from the European Commission, the Panel on Biological Hazards (BIOHAZ) was asked to deliver a Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum beta (β)-lactamases (ESBL) and/or AmpC β-lactamases (AmpC) in food and foodproducing animals. In particular, the Panel was asked: (i) to propose a definition of the ESBL-and/or AmpC-producing bacterial strains and genes relevant for public health and linked to food-producing animals or food borne transmission; (ii) to review the information on the epidemiology of acquired resistance to broad spectrum cephalosporins including the genes coding for ...

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Section: Esbl-subtypes Detected In E Coli and Salmonella From Food-pmentioning

confidence: 99%

Section: Esbl-subtypes Detected In E Coli and Salmonella From Food-pmentioning

confidence: 99%

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

2011

EFSA Journal

246

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“…Ireland recently reported the presence of S. Kentucky in broilers demonstrating resistance to thirdgeneration cephalosporins (Boyle et al, 2010). Isolates were recovered from chicken neck skin, birds and broiler house dust samples, and affected broiler farms were stocked from one broiler breeder farm.…”

Section: Resistance Levels In S Kentucky From Poultrymentioning

confidence: 99%

The European Union Summary Report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2010

2012

EFS2

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The antimicrobial resistance data on zoonotic and indicator bacteria in 2010, submitted by 26 European Union Member States, were jointly analysed by the European Food Safety Authority and the European Centre for Disease Prevention and Control. Data covered resistance in zoonotic Salmonella and Campylobacter from humans, food and animals, and in indicator Escherichia coli and enterococci from animals and food. Some data on meticillin-resistant Staphylococcus aureus in animals and food were also included. In isolates from humans, resistance was mainly interpreted using clinical breakpoints, whereas in animal and food isolates, microbiological resistance was defined using epidemiological cut-off values. No major changes in resistance in monitored bacteria were observed compared with previous years. Resistance was commonly found in isolates from humans, animals and food, although disparities in resistance were frequently observed between Member States. High resistance levels were recorded to ampicillin, tetracyclines and sulfonamides in Salmonella isolates from humans, whereas resistance to third-generation cephalosporins and fluoroquinolones remained low. In Salmonella and indicator E. coli isolates from fowl, pigs, cattle and meat thereof, resistance to tetracyclines, ampicillin and sulfonamides was also commonly detected, whereas resistance to third-generation cephalosporins was low. Moderate to high levels of ciprofloxacin (a fluoroquinolone) resistance were observed in Salmonella isolates from turkeys, fowl and broiler meat. In Campylobacter isolates from human cases, resistance to ampicillin, ciprofloxacin, nalidixic acid and tetracyclines was high, while resistance to erythromycin was recorded at low to moderate levels. High resistance to ciprofloxacin, nalidixic acid and tetracyclines was also observed in Campylobacter isolates from fowl, broiler meat, pigs and cattle, whereas much lower levels were observed for erythromycin and gentamicin. Among the indicator enterococci isolates from animals and food, resistance to tetracyclines and erythromycin was commonly detected. Meticillin-resistant Staphylococcus aureus was detected in some animal species and food of animal origin. mission is to identify, assess and communicate current and emerging threats to human health posed by infectious diseases. In order to achieve this mission, ECDC works in partnership with national public health bodies across Europe to strengthen and develop EU-wide disease surveillance and early warning systems. By working with experts throughout Europe, ECDC pools Europe's knowledge in health so as to develop authoritative scientific opinions about the risks posed by current and emerging infectious diseases. About the report SummaryZoonoses are infections and diseases that are transmissible between animals and humans. Infection can be acquired directly from animals, or through the ingestion of contaminated foodstuffs or other indirect contact. The severity of these infections in humans can vary from mild and asymptomatic to serio...

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“…The first report of the occurrence of extended spectrum β-lactamase (ESBL) resistant S. Kentucky from poultry specimens (whole chicken, farm dust and chicken neck skin) in Ireland was attributed to bla SHV-12 and bla CMY-2 genes. Even though cephalosporins are not applicable for the therapy of chickens in Ireland, there is a possibility that the use of amoxicillin has favored the selection of β-lactamase producers over the time (Boyle et al, 2010). Salmonella Kentucky designated CVM29188 isolated from a chicken breast sample in the year 2003 has shown resistance to streptomycin, tetracycline, ampicillin and ceftiofur.…”

Section: B I O F I L M F O R M I N G C a Pa C I T Y O F Salmonella Spmentioning

confidence: 99%

Salmonella spp. in poultry: a constant challenge and new insights

Velhner

Milanov

Kozoderović

2018

J Hellenic Vet Med Soc

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ABSTRACT. The knowledge about virulence mechanisms, resistance to antimicrobial agents and the biofilm formation ability of Salmonella spp. in poultry industry has been expanded over the years. However, in spite of the research efforts and significant investments to improve management systems in poultry industry, it has become evident that none of the methods applied in all stages of food production chain are 100% effective in eliminating Salmonella spp. Different serovars are manifesting different mechanisms of invasiveness which depend on their ability to invade lower zones of the lamina propria, their ability to gain accesses to parenchymatous organs and survive in macrophages. The ubiquitous nature of Salmonella spp. due to their adaptation to animal and plant hosts, as well as their survival in hostile environments and their enhanced capacity to produce biofilms, contribute to a long lasting contamination of the environment, feed and animals. The emergency and spread of antimicrobial resistances in Salmonella spp. raise additional concerns.

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First Report of Extended-Spectrum-β-Lactamase-Producing Salmonella enterica Serovar Kentucky Isolated from Poultry in Ireland

Cited by 27 publications

References 20 publications

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

The European Union Summary Report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2010

Salmonella spp. in poultry: a constant challenge and new insights

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