First report of fungal meningoencephalitis by Penicillium chrysogenum in Brazil

Oliveira, Rômulo Vieira Mello de; Corrêa‐Moreira, Danielly; Mendes, Túlio Vieira; Costa, Gisela Lara da; Vieira, Renata de Magalhães; Buchele, Cynthia Miranda Nascimento; Lins, Rodrigo Schrage; Ferreira, Ana Beatriz Teixeira Brandão Camello; Veira, Daniela Barbosa; Pedroso, Rafael Santos de Aragão; Faria, Vinícius Tadeu Dias Pereira de; Oliveira, Manoel Marques Evangelista

doi:10.1016/j.ijid.2022.11.015

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Other species like P. chrysogenum that were isolated from the soil samples can also cause invasive infections in immunocompromised patients [62,63], including children [64]. Alarmingly, the first case of meningoencephalitis caused by P. chrysogenum was found in a patient previously considered immunocompetent and was recently described [65]. It should be noted that currently there is no antifungal remedy of choice for the management of penicilliosis [64].…”

Section: Discussionmentioning

confidence: 99%

Diversity of Soil-Borne Fungi Isolated from Places Frequently Visited by People in the City of Wrocław (Poland)

Spychała,

Kłosińska,

Salwińska

et al. 2024

Applied Sciences

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In this study, we identified culturable microscopic fungi in soil from areas frequented by people (parks, allotments, and other green areas) in the city of Wrocław (Poland). In addition to general species analysis, attention was focused on keratin-degrading fungi. From 60 soil samples (12 study sites), we obtained 75 isolates of keratinophilic and keratinolytic fungi using the hair bait method, and 54 isolates of fungi were isolated on PDA (Potato Dextrose Agar) medium. Based on morphological and molecular analyses, a total of 37 strains were identified, classified into 2 phyla, 11 families, 17 genera, and 30 filamentous species. The mean values of the Shannon Diversity Index for both experimental variants ranged from 0.074 to 0.117. The most common species was the Penicillium genus, which accounted for 33.33% of all fungal species obtained in these studies. These fungi are common in both indoor and outdoor environments. However, particularly noteworthy in this study are the species belonging to the group of dermatophytes (Arthroderma uncinatum, Keratinophyton wagnerii, Nannizzia gypsea, and Paraphyton cookei), which may pose a real biological threat to humans and animals due to their well-known potential to cause dermatomycosis.

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Section: Discussionmentioning

confidence: 99%

Diversity of Soil-Borne Fungi Isolated from Places Frequently Visited by People in the City of Wrocław (Poland)

Spychała,

Kłosińska,

Salwińska

et al. 2024

Applied Sciences

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confidence: 99%

“…Recently, articles were published describing Fusarium solani as the causal agent of an outbreak of meningitis in Mexico and USA, both in immunosuppressed and immunocompetent patients (Hoenigl et al, 2023;Garcıá-Rodrıǵuez et al, 2024). In 2023, our group also published a case report of meningoencephalitis caused by Penicillium chrysogenum, a fungus widely distributed in nature, which, like C. auris, present in the high-priority group, acquired the ability to adapt to temperatures and cause diseases in healthy hosts (de Oliveira et al, 2023). Some factors may contribute to the emergence and reemergence of these fungal pathogens, the main of which are human actions that result in climate change and induce fungal adaptative thermotolerance by reducing the difference between environmental and mammalian temperatures (Casadevall et al, 2019).…”

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confidence: 99%