First Report of Genotype E of Hepatitis B Virus in an Indian Population

Singh, Jasbir; Dickens, Caroline; Pahal, Vikas; Kumar, Rajesh; Chaudhary, Rajender; Kramvis, Anna; Kew, Michael C.

doi:10.1159/000227279

Cited by 18 publications

(15 citation statements)

References 23 publications

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“…of Sharma et al, 21 who observed genotype D and genotype A in North Indian patients, and in accordance with the study of Madan et al, 22 who observed genotype D and A but we did not observe genotype C as the study of Madan et al, 22 and in accordance with the study of Singh et al, 23 who observed genotype D and A in North Indian population. But, we did not observe genotype E in our population as the study of Singh et al, 23 in accordance with the study of Kar et al 24 Chattopadhyay et al 25 reported predominance of genotype D followed by genotype A among patients with chronic liver disease from New Delhi.…”

Section: Conflicts Of Interestsupporting

confidence: 92%

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Prevalence of Genotype D and Precore/Core Promoter Mutations in Hepatitis B Virus-infected Population of North India

Kumar¹,

Pahal²,

Singh³

2011

Journal of Clinical and Experimental Hepatology

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Hepatitis B virus (HBV) isolates (21) from Punjab (North India) were studied for genotype distribution and precore/core promoter mutations. Assays of alanine aminotransaminase (ALT) and HBeAg were performed in all isolates. Genotypes were determined in all the samples by restriction fragment length polymorphism and the precore/core promoter mutations were studied by amplification and by direct sequencing of precore/core promoter region. Sixty-two percent of the isolates had higher ALT levels and 57% of the isolates were HBeAg negative. It was observed that 90% of the isolates were HBV D genotype (subgenotype D1 and D2) and 10% of the isolates were HBV A genotype (subgenotype A1). Amplification and sequencing of the precore/core promoter region showed

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Section: Conflicts Of Interestsupporting

confidence: 92%

“…But, we did not observe genotype E in our population as the study of Singh et al, 23 in accordance with the study of Kar et al 24 Chattopadhyay et al 25 reported predominance of genotype D followed by genotype A among patients with chronic liver disease from New Delhi.…”

Section: Conflicts Of Interestsupporting

confidence: 87%

Prevalence of Genotype D and Precore/Core Promoter Mutations in Hepatitis B Virus-infected Population of North India

Kumar¹,

Pahal²,

Singh³

2011

Journal of Clinical and Experimental Hepatology

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“…HBV/D with subtypes D1–D5 is prevalent in the Mediterranean region expanding through South Asia up to India [8]. HBV/E is restricted to West Africa [11] but some studies reported the presence of this genotype in South America [12] and India [13]. This genotype is characterized by a low genetic diversity among strains from throughout the world [14].…”

Section: Resultsmentioning

confidence: 99%

Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil

et al. 2013

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BackgroundHBV genotype F is primarily found in indigenous populations from South America and is classified in four subgenotypes (F1 to F4). Subgenotype F2a is the most common in Brazil among genotype F cases. The aim of this study was to characterize HBV genotype F2a circulating in 16 patients from São Paulo, Brazil. Samples were collected between 2006 and 2012 and sent to Hospital Israelita Albert Einstein. A fragment of 1306 bp partially comprising HBsAg and DNA polymerase coding regions was amplified and sequenced. Viral sequences were genotyped by phylogenetic analysis using reference sequences from GenBank (n=198), including 80 classified as subgenotype F2a. Bayesian Markov chain Monte Carlo simulation implemented in BEAST v.1.5.4 was applied to obtain the best possible estimates using the model of nucleotide substitutions GTR+G+I.FindingsIt were identified three groups of sequences of subgenotype F2a: 1) 10 sequences from São Paulo state; 2) 3 sequences from Rio de Janeiro and one from São Paulo states; 3) 8 sequences from the West Amazon Basin.ConclusionsThese results showing for the first time the distribution of F2a subgenotype in Brazil. The spreading and the dynamic of subgenotype F2a in Brazil requires the study of a higher number of samples from different regions as it is unfold in almost all Brazilian populations studied so far. We cannot infer with certainty the origin of these different groups due to the lack of available sequences. Nevertheless, our data suggest that the common origin of these groups probably occurred a long time ago.

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“…Genotype E has been isolated from Pygmies [33] and the Khoi San [Kramvis, unpubl. data], and in Colombia [34] and India [35] in individuals with no history of travel to or from Africa. Without an accurate determination of the nucleotide substitution rate of HBV, the variance of the estimated age of genotype E will be difficult to resolve.…”

Section: Genotype Ementioning

confidence: 99%

Genotypes and Genetic Variability of Hepatitis B Virus

Kramvis¹

2014

Intervirology

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Sequence heterogeneity is a feature of hepatitis B virus (HBV), the prototype member of the family Hepadnaviridae. Based on an intergroup divergence of greater than 7.5% across the complete genome, HBV has been classified phylogenetically into 9 genotypes, A-I, with a putative 10th genotype ‘J', isolated from a single individual. With between approximately 4 and 8% intergroup nucleotide divergence across the complete genome and good bootstrap support, genotypes A-D, F, H, and I are classified further into subgenotypes. There is a broad and highly statistically significant correlation between serological subtypes and genotypes, and in some cases, serological subtypes can be used to differentiate subgenotypes. The genotypes, and certain subgenotypes, have distinct geographical distributions and are important in both the clinical manifestation of infection and response to antiviral therapy. HBV genotypes/subgenotypes and genetic variability of HBV are useful in epidemiological and transmission studies, tracing human migrations, and in predicting the risk for the development of severe liver disease and response to antiviral therapy. Moreover, knowledge of the genotype/subgenotype is important in implementing preventative strategies. Thus, it is crucial that new strains are correctly assigned to their respective genotype/subgenotype and consistent, unambiguous, and generally accepted nomenclature is utilized.

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First Report of Genotype E of Hepatitis B Virus in an Indian Population

Cited by 18 publications

References 23 publications

Prevalence of Genotype D and Precore/Core Promoter Mutations in Hepatitis B Virus-infected Population of North India

Prevalence of Genotype D and Precore/Core Promoter Mutations in Hepatitis B Virus-infected Population of North India

Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil

Genotypes and Genetic Variability of Hepatitis B Virus

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