First Report of Human Pancreas Transplantation Using IGL-1 Preservation Solution

Chedid, Marcio; Grezzana-Filho, T.J.M.; Montenegro, Rosangela Munhoz; Leipnitz, Ian; Hadi, Riad Abdel; Chedid, Aljamir Duarte; Kruel, Cléber Rosito Pinto; Ribeiro, Alexandre Moretto; Gressler, Juliano B.; Denicol, Nancy Tamara; Kruel, Cleber D.P.; Manfro, Roberto Ceratti

doi:10.1097/tp.0000000000001242

Cited by 11 publications

(12 citation statements)

References 6 publications

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“…Pancreas preservation with IGL-1 of up to 17 hours was reported. [24] These findings seem to match the scarce preclinical data studying IGL-1 in pancreas transplantation. When IGL-1 was compared to UW in a model of pig pancreas transplantation, it offered the same degree of safety and effectiveness as UW.…”

Section: Plos Onesupporting

confidence: 58%

“…Two articles reported on clinical trials using IGL-1 in kidney transplantation [22,23]; two discussed case series of the use of IGL-1 in simultaneous kidney pancreas transplantation. [24,25] Broadening the search resulted in three abstracts and four animal PLOS ONE studies included in this systematic review. Additional snowballing and searching of registry databases (on January 15 th , 2020) separately could not identify any additional records or ongoing or unpublished trials.…”

Section: Resultsmentioning

confidence: 99%

“…The clinical case series reporting on IGL-1 used in pancreas transplantation suggest that IGL-1 is a safe and effective solution. [24,25] In both articles no pancreas dysfunction was noted and all patients became independent of insulin after transplantation. Pancreas preservation with IGL-1 of up to 17 hours was reported.…”

Section: Plos Onementioning

confidence: 93%

“…[29,30] The use of IGL-1 in simultaneous kidney pancreas transplantation Chedid et al described 5 consecutive cases of simultaneous kidney and pancreas transplantation using IGL-1 as a cold storing solution (Table 4). [24] All pancreata acquired normal function and insulin independency immediately after reperfusion. Three out of five patients developed DGF of the kidney graft.…”

Section: Plos Onementioning

confidence: 97%

“…[22,23] The quality of the case series (level 4 studies) on simultaneous kidney pancreas transplantation, assessed with the NIH tool for case series, was good (S6 Table). [24,25] In both case series the study objective and the study population were clearly defined. The intervention and the outcome measures were also clearly described.…”

Section: Quality Assessment and Risk Of Biasmentioning

confidence: 99%

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IGL-1 preservation solution in kidney and pancreas transplantation: A systematic review

2020

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We aimed to systematically review published data on the effectiveness of Institut Georges Lopez-1 (IGL-1) as a preservation solution for kidney and pancreas grafts. A systematic literature search of PubMed, Embase, Web of Science, and the Cochrane Library databases was performed. Human studies evaluating the effects of IGL-1 preservation solution in kidney and/or pancreas transplantation were included. Outcome data on kidney and pancreas graft function were extracted. Of 1513 unique articles identified via the search strategy, four articles could be included in the systematic review. Of these, two retrospective studies reported on the outcome of IGL-1 compared to University of Wisconsin (UW) solution in kidney transplantation. These show kidneys preserved in IGL-1 had improved early function (2 weeks post-transplant) compared to UW. Follow-up was limited to 1 year and showed similar graft and patient survival rates when reported. Two case series described acceptable early outcomes (up to 1 month) of simultaneous kidney pancreas transplantation after storage in IGL-1. As only four clinical papers were identified, we widened our search to include four eligible large animal studies. Three compared IGL-1 with UW in pig kidney transplant models with inconclusive or mildly positive results. One pig pancreas transplant study suggested better early outcome with IGL-1 compared to UW. Too few published data are available to allow any firm conclusions to be drawn on the effectiveness of IGL-1 as a preservation solution of kidney and pancreas grafts. The limited available data show satisfactory early outcomes though no medium to long-term outcomes have been described. Further well-designed clinical studies are needed.

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Section: Plos Onesupporting

confidence: 58%