First Report of <i>Paraphaeosphaeria recurvifoliae</i> on <i>Yucca filamentosa</i> in Western Poland

Six new polyketides named paraverrucsins A−F (1− 6) with oxabicyclic and dioxatricyclic skeletons, together with eight known metabolites (7−14), were discovered and isolated from the fermentation medium of Paraphaeosphaeria verruculosa. Paraverrucsin A−C possessed a novel decarboxylated skeleton compared with that of trichocladinols. Their structures were elucidated by extensive spectral analysis and DP4+ calculations. Paraverrucsins B/C and D/E were isolated as a mixture for the mutarotation occurred at C-2. Paraverrucsins B/C, D/E, F/ trichocladinol B, 8, and 9 displayed antifeedant activities against silkworm larvae, with antifeedant index percentages ranging from 62.5 to 93.0%, at a concentration of 50 μg/cm 2 . Among them, Paraverrucsins B/C and 9 had EC 50 values at 13.9 and 18.2 μg/cm 2 . Most compounds showed antifungal activities against phytopathogenic fungi with minimum inhibitory concentration (MIC) values of 16−64 μg/mL. Coculture of P. verruculosa and host plant Dendrobium officinale leads to the enhancement of antifeedant and antiphytopathogenic activities. Compounds 1, 2/3, 4/5, 6/14 were tested for cytotoxicity against five human carcinoma cell lines, HL-60, A549, MCF-7, SW480, and SMMC-7721, while they exhibited selected cytotoxicity against SW480 with inhibition ratios of 32−38% at a concentration of 40 μM.

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“…Paraphaeosphaeria sp. had been regarded as pathogenic fungi . Previous works led to many new metabolites from Paraphaeosphaeria sp.…”

Section: Introductionmentioning

confidence: 99%

Paraverrucsins A–F, Antifeedant, and Antiphytopathogenic Polyketides from Rhizospheric Paraphaeosphaeria verruculosa and Induced Bioactivity Enhancement by Coculturing with Host Plant Dendrobium officinale

Yang

Wang

et al. 2020

ACS Omega

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Sooty leaf spot—a new fungal disease of sorghum caused by Paraphaeosphaeria sorghi sp. nov

Paula

Barreto

Nóbrega

2022

Trop. plant pathol.

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First Report of Leaf Spots and Necrosis Caused by Paraphaeosphaeria recurvifoliae on Yucca gloriosa in China

Ding

Guo

et al. 2020

Plant Disease

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First Report of Paraphaeosphaeria recurvifoliae on Yucca filamentosa in Western Poland

Cited by 3 publications

References 3 publications

Paraverrucsins A–F, Antifeedant, and Antiphytopathogenic Polyketides from Rhizospheric Paraphaeosphaeria verruculosa and Induced Bioactivity Enhancement by Coculturing with Host Plant Dendrobium officinale

Paraverrucsins A–F, Antifeedant, and Antiphytopathogenic Polyketides from Rhizospheric Paraphaeosphaeria verruculosa and Induced Bioactivity Enhancement by Coculturing with Host Plant Dendrobium officinale

Sooty leaf spot—a new fungal disease of sorghum caused by Paraphaeosphaeria sorghi sp. nov

First Report of Leaf Spots and Necrosis Caused by Paraphaeosphaeria recurvifoliae on Yucca gloriosa in China

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