First Report of Successful Total Pancreatectomy and Islet Autotransplant in Australia

Geyer, Myfanwy Clare; Coates, P. Toby; Khurana, Sanjeev; Chen, John W C; Kay, Thomas W. H.; Balamurugan, Appakalai N.; Couper, Jennifer; Radford, Toni; Drogemuller, Chris; Loudovaris, Thomas; Pathi, Ramon; Wilks, Michael; Couper, Richard

doi:10.1097/mpa.0000000000000769

Cited by 3 publications

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“…TP‐IAT was first performed in Australia in 2010 at Westmead Hospital (WM) in Sydney. Since then, a total of 16 TP‐IAT procedures have been performed by the Australian Islet Transplant Consortium, with islets isolated at Westmead Hospital for New South Wales (NSW) cases and at St Vincent's Hospital Melbourne via pancreas shipping for South Australian (SA) cases 3 …”

Section: Introductionmentioning

confidence: 99%

“…Since then, a total of 16 TP-IAT procedures have been performed by the Australian Islet Transplant Consortium, with islets isolated at Westmead Hospital for New South Wales (NSW) cases and at St Vincent's Hospital Melbourne via pancreas shipping for South Australian (SA) cases. 3 In the current report, we detail the clinical outcomes of all recipients of TP-IAT for chronic and hereditary pancreatitis in Australia from 2010 to 2020.…”

Section: Introductionmentioning

confidence: 99%

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Australian experience with total pancreatectomy with islet autotransplantation to treat chronic pancreatitis

Bampton

Holmes-Walker

Drogemuller

et al. 2021

ANZ Journal of Surgery

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Background: This study aimed to describe the clinical outcomes of total pancreatectomy with islet autotransplantation (TP-IAT) in Australia. Methods: Individuals selected for TP-IAT surgery according to the Minnesota Criteria (Appendix) without evidence of diabetes were evaluated including time to transplantation from pancreatectomy, islet numbers infused and post-transplantation HbA1c, C-peptide, total daily insulin and analgesic requirement. Results: Sixteen individuals underwent TP-IAT from Australia and New Zealand between 2010 and 2020. Two recipients are deceased. The median islet equivalents/kg infused was 4244 (interquartile range (IQR) 2290-7300). The median C-peptide 1 month post-TP-IAT was 384 (IQR 210-579) pmol/L and at median 29.5 (IQR 14.5-46.5) months from transplant was 395 (IQR 139-862) pmol/L. Insulin independence was achieved in eight of 15 (53.3%) surviving recipients. A higher islet equivalents transplanted was most strongly associated with the likelihood of insulin independence (P < 0.05). Of the 15 surviving recipients, 14 demonstrated substantial reduction in analgesic requirement. Conclusion:The TP-IAT programme in Australia has been a successful new therapy for the management of individuals with chronic pancreatitis including hereditary forms refractory to medical treatment to improve pain management with 50% insulin independence rates.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%