First report of the aac(6’)-Ib-cr gene in Providencia stuartii isolates in Brazil

Silva, Sivoneide Maria da; Ramos, Bárbara de Azevedo; Lima, Adilson Celestino de; Sá, Rafael Artur Cavalcanti Queiroz de; Lima, Jailton Lobo da Costa; Maciel, Maria Amélia Vieira; Paiva, Patrícia Maria Guedes; Silva, Márcia Vanusa da; Correia, Maria Tereza dos Santos; Oliveira, Maria Betânia Melo de

doi:10.1590/0037-8682-0524-2019

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…In addition, the aac(6 )-Ib-cr mutant gene encodes resistance to both fluoroquinolones and aminoglycosides. The frequency of aac( 6)-Ib-cr found in this study exceeds those found in previous studies in Brazil (up to 4%) in clinical Pseudomonas aeruginosa and Providencia stuartii isolates [22,23] and from samples obtained in different countries, which ranged from 12% to 23.3% [24,25]. Notably, the use of broad-spectrum bactericidal aminoglycosides routinely in children, primarily for infections caused by Gram-negative fluoroquinolone-resistant pathogens, has increased worldwide [26].…”

Section: Discussioncontrasting

confidence: 60%

First Report of aac(6′)-Ib and aac(6′)-Ib-cr Variant Genes Associated with Mutations in gyrA Encoded Fluoroquinolone Resistance in Avian Campylobacter coli Strains Collected in Tunisia

Gharbi,

Abbas,

Hamrouni

et al. 2023

IJMS

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The aac(6′)-Ib gene is the most widespread gene encoding aminoglycoside-modifying enzyme and conferring resistance to tobramycin, streptomycin and kanamycin. The variant aac(6′)-Ib-cr gene confers resistance to both aminoglycosides and fluoroquinolones (FQ). A total of 132 Campylobacter isolates, including 91 C. jejuni and 41 C. coli, were selected from broiler hens isolates. The aac(6′)-Ib gene was amplified using PCR and was subsequently digested with the BtsCI restriction enzyme to identify aac(6′)-Ib-cr. Among these isolates, 31 out of 41 C. coli (75.6%) and 1 (0.98%) C. jejuni were positive for the aac(6′)-Ib gene, which was identified as the aac(6′)-Ib-cr variant in 10 (32.25%) C. coli isolates. This variant was correlated with mutations in gyrA (Thr-86-Ile), as well as resistance to FQs. This study is the first report in Tunisia on Campylobacter coli strains harboring both the aac(6′)-Ib and aac(6′)-Ib-cr variants. These genes were present in Campylobacter isolates exhibiting resistance to multiple antibiotics, which restricts the range of available treatments.

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Section: Discussioncontrasting

confidence: 60%

First Report of aac(6′)-Ib and aac(6′)-Ib-cr Variant Genes Associated with Mutations in gyrA Encoded Fluoroquinolone Resistance in Avian Campylobacter coli Strains Collected in Tunisia

Gharbi,

Abbas,

Hamrouni

et al. 2023

IJMS

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“…The main Providencia species involved in human pathology are P. stuartii and P. rettgeri which can produce urinary tract infections, pneumonia, meningitis, wound infections, endocarditis, osteomyelitis, intraabdominal and bloodstream infections in hospitalized patients [1], [2], [9], [10], [11], [12].…”

Section: Introductionmentioning

confidence: 99%

“…amikacin, ciprofloxacin, trimethoprim-sulfa-metoxazole, aztreonam and resistant to the aminopenicillins, firstgeneration cephalo-sporins, gentamicin, tobramycin. They also have intrinsic resistance to colistin and to tigecycline [10].…”

Section: Introductionmentioning

confidence: 99%

Providencia Species – Involvement in Pathology and Multidrug Resistance in a Romanian County Hospital

Idomir

2021

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The aim of the study was to evaluate the distribution on hospital wards, the spectrum of infections and the pattern of antimicrobial resistance of Providencia strains identified between 01.01.2018-31.12.2020 in the samples of the patients hospitalized in the Clinical County Emergency Hospital of Brasov. 380 strains of Providencia species were identified in the medical and surgical wards, especially in ICU (76.84%), Internal medicine ward (5.79%) and General surgery (3.95%). More frequently, Providencia spp. were isolated from tracheobronchial secretions (35.79%), pus (22.89%) and urine (19.74%). The levels of antimicrobial resistance of Providencia strains were very high for all the tested antimicrobials.

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Epidemiological and molecular study of Providencia rettgeri outbreak at a university hospital during the COVID-19 reference center

Da Silva Pimenta,

Magalhães,

Soncini

et al. 2024

Int Microbiol

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First report of the aac(6’)-Ib-cr gene in Providencia stuartii isolates in Brazil

Cited by 5 publications

References 12 publications

First Report of aac(6′)-Ib and aac(6′)-Ib-cr Variant Genes Associated with Mutations in gyrA Encoded Fluoroquinolone Resistance in Avian Campylobacter coli Strains Collected in Tunisia

First Report of aac(6′)-Ib and aac(6′)-Ib-cr Variant Genes Associated with Mutations in gyrA Encoded Fluoroquinolone Resistance in Avian Campylobacter coli Strains Collected in Tunisia

Providencia Species – Involvement in Pathology and Multidrug Resistance in a Romanian County Hospital

Epidemiological and molecular study of Providencia rettgeri outbreak at a university hospital during the COVID-19 reference center

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