First report on chlorophyllin to protect mammalian and fish muscle cells from pesticide toxicity via activation of p53 and PARP

Nano-pelargonidin modulates p53/PARP/HSP 90/XRCC1 signaling axis to combat cypermethrin-induced genotoxicity and metabolic dysfunction in fish: a molecular docking predictedin vivoapproach

“…27,28 In this research work, plant-derived chemicals were preferred over synthetic molecules due to their non-toxicity/ limited toxicity, low cost, and ease of availability. Phytocompounds have previously been utilized by various researchers to combat pesticide-induced toxicity in fish and other animals [29][30][31][32][33][34][35][36] and are reported to provide enormous health advantages. Phytocompounds are now routinely employed in lifestyle care products, including in vegetables, medications, healthcare beverages, and cosmetics.…”

“…The phytocompound pelargonidin (PG), a natural anthocyanidin, has been reported to exhibit vaso-protective, 40 anti-inflammatory, 41 anti-carcinogenic, 42 anti-obesity, 43 and anti-diabetic 44,45 activities by rescuing cells and tissues from cytotoxicity and genotoxicity caused by several toxicants, both in its phytochemical form and nano-encapsulated forms. 16–49 On the other hand, several toxicological investigations of xenobiotics have found a correlation with the impairment of key DNA repair proteins, such as p53, PARP, HSP 90, and XRCC1, which promote dysfunction of signalling cascades and ultimately lead to genetic instability. 18,24,33,39 Therefore, an approach based on nanotechnology was exploited in the present study to address the issue of cypermethrin (CM) pesticide-induced genotoxicity in a tilapia fish model, whereby the phytocompound PG was encapsulated in PLGA to check whether the formulated nano-pelargonidin (NPG) would play a beneficial role in inhibiting the progression and intense complications that may develop in fish when exposed to the toxic chemical pesticide CM.…”

“…16–49 On the other hand, several toxicological investigations of xenobiotics have found a correlation with the impairment of key DNA repair proteins, such as p53, PARP, HSP 90, and XRCC1, which promote dysfunction of signalling cascades and ultimately lead to genetic instability. 18,24,33,39 Therefore, an approach based on nanotechnology was exploited in the present study to address the issue of cypermethrin (CM) pesticide-induced genotoxicity in a tilapia fish model, whereby the phytocompound PG was encapsulated in PLGA to check whether the formulated nano-pelargonidin (NPG) would play a beneficial role in inhibiting the progression and intense complications that may develop in fish when exposed to the toxic chemical pesticide CM.…”

Modulação da ecotoxicidade de contaminantes ambientais por óxido de grafeno

“…Os agrotóxicos podem evaporar, infiltrar-se no solo, ou ser carreados por meio de mecanismos de transportes de seus locais de aplicação para rios e águas subterrâneas [61,62]. Quando presentes em corpos hídricos, esses compostos podem afetar comunidades aquáticas, como microcrustáceos, peixes e outros organismos [62].…”