First Report on HLA<i>-DPB1</i>Gene Allelic Distribution in the General Lebanese Population

Shammaa, Dina; Khansa, Sara; Zaatari, Ghazi; Mahfouz, Rami

doi:10.1089/gtmb.2009.0186

Cited by 3 publications

(6 citation statements)

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“…The most predominant allele in our study population was DPA1 *0103 with a prevalence rate of 86.14% which is very similar in being the highly prevalent population-specific allele for all of the European countries and populations included in this study like the Basque population in Spain ( Begovich et al, 2001 ), Caucasoid (Swedish) ( Cheng et al, 2014 ), and individuals of European ancestry ( Shammaa et al, 2010 ), in addition to Tokelau of the Pacific Islands ( Mori et al, 1996 ). This information is pertinent if we mention here the historical fact about Lebanon being previously under the influence of the Crusaders invasion of the region with all inter-marriages that took place among different populations and communities then.…”

Section: Discussionmentioning

confidence: 54%

“…In light of these results, the similarity between the studied Lebanese population and individuals of European ancestry ( Shammaa et al, 2010 ) was most appealing. The descending order of percentages in terms of most to least frequent allelic variations is remarkably similar.…”

Section: Discussionmentioning

confidence: 99%

“…The aims of this study are to detect the different HLA- DPA1 alleles in the Lebanese population ( Aldener-Cannavá and Olerup, 1996 ) and to compare them to the published literature in different countries such as the Basque population in Spain ( Begovich et al, 2001 , Pérez-Miranda et al, 2004 ), Caucasoid (Swedish) ( Cheng et al, 2014 ) and West African (Gambia) ( Díaz-Peña et al, 2013 ) populations ( Aldener-Cannavá and Olerup, 1996 ), Caucasoid (British) ( Gan et al, 2015 ) population ( Sage et al, 1994 ), Japanese ( Harada et al, 1992 ), Papua New Guinean ( Hollenbach et al, 2012 ), and Buyi-Chinese ( Khansa et al, 2012 ) populations ( Harada et al, 1992 ), four Pacific islands ( Khansa et al, 2013 , Lantermann et al, 2002 , Mori et al, 1996 , Morishima et al, 2015 ) populations (Cook Islands ( Khansa et al, 2013 ), Samoa ( Lantermann et al, 2002 ), Tokelau ( Mori et al, 1996 ), Tonga ( Morishima et al, 2015 ); ( Velickovic and Carter, 2001 ), Guadeloupe ( Pérez-Miranda et al, 2004 ) population ( Voorter et al, 2014 ), Cameroon ( Petersdorf et al, 2001 ), Ecuadorian African ( Sage et al, 1994 ), and Indonesian ( Schaffer et al, 2003 ) populations ( Begovich et al, 2001 ), and individuals of European ancestry ( Shammaa et al, 2010 , Hollenbach et al, 2012 ). This study is the first to describe the different allele frequency in the Lebanese population and can be later used for disease association studies.…”

Section: Introductionmentioning

confidence: 99%

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First report on HLA -DPA1 gene allelic distribution in the general Lebanese population

et al. 2016

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AimsHLA-DPA1 is an important marker in bone marrow and organ transplantation and a highly emerging screening parameter in histocompatibility laboratories. Being highly polymorphic, it has another significant value in detecting population origins and migrations. This is the first study to assess DPA1 allele frequencies in an Arab population.MethodsThe HLA DPA1 alleles were identified using the One-Lambda assays on a Luminex reverse SSO DNA typing system. Our study included 101 individuals coming from different Lebanese geographical areas representing the different communities and religious sects of the country.ResultsWe compared the results of this study to 16 different populations and found very interesting similarities and differences between Lebanese people and individuals of European ancestry.ConclusionThis study is the first to describe the different allelic frequencies of HLA-DPA1 in the Lebanese population and will serve as a template that can be later used for disease association studies both at the level of the country and internationally.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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First report on HLA -DPA1 gene allelic distribution in the general Lebanese population

et al. 2016

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“…Comparison of haplotypes with other ethnic groups was based on data from the National Marrow Donor Program . Available reference data on the distribution of HLA alleles in Arabs and Lebanese was used for comparison .…”

Section: Methods and Subjectsmentioning

confidence: 99%

“…The HLA typing community has been very closely associated with anthropological studies from the very beginning. Nevertheless there is scanty data available regarding the distribution of HLA alleles in Lebanese and Arabic populations . This study has two purposes: first, to make a contribution to our understanding of the distribution of HLA alleles and haplotypes in genetically less characterised populations and second, to present some new concepts for estimation of both genetic diversity and linkage disequilibrium.…”

Section: Introductionmentioning

confidence: 99%

HLA population genetics: a Lebanese population

et al. 2012

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Human leukocyte antigen (HLA) typing was done in 426 Lebanese subjects of 88 families, in which 347 haplotypes were identified. The A, B, C, DRB1, DRB3/4/5, DQB1 and DPB1 loci were typed at high resolution. This study shows that information theory, as originally developed by Claude Shannon in 1948, provides a promising theoretical foundation to study the population genetics of a genetic system like HLA. Although Lebanese carry HLA alleles found in other populations, the association of these alleles into haplotypes is quite unique. Comparisons are made with the main ethnic groups. Two haplotypes well represented in the Lebanese population are not identified in any global population: L1 = {A*26:01:01 - B*35:01:01:01- C*04:01:01:01- DRB1*16:01:01 - DRB5*02:02 - DQB1*05:02:01} and L2 = {A*02:02 - B*41:01- C*17:01:01:01 -DRB1*11:04:01 - DRB3*02:02:01:01- DQB1*03:01:01:01}. By studying linkage disequilibrium in two blocks at a time, with the division of the blocks at different levels in consecutive cycles, conserved haplotypes in full linkage disequilibrium come to light, such as {A*26:01:01- B*35:01:01:01 - C*04:01:01:01 - DRB1*16:01:01 - DRB5*02:02 - DQB1*05:02:01- DPB1*03:01:01} and {A*33:01:01 - B*14:02:01 - C*08:02:01 - DRB1*01:02:01- DQB1*05:01:01:01 - DPB1*04:01:01:01}.

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HLA Class I allele frequencies in the Lebanese population

Khansa

Hoteit

Shammaa

et al. 2013

Gene

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The highly polymorphic Human Leukocyte Antigen system encompasses different loci that have been studied in transplantation as well as diseases and population associated research. This study is the first and largest of its kind to describe the distribution of HLA-A, -B and -C alleles in Lebanon. Respectively, 1994, 1309 and 1163 Lebanese individuals referred for HLA typing and possible bone marrow/kidney donation were tested for HLA-A, HLA-B and HLA-C alleles using the polymerase chain reaction/Sequence specific priming (PCR-SSP) method. Our data were compared to that of several populations with interesting and common findings shared with the Moroccan, Jordanian, Tunisian, Omani, Korean, Chinese, Japanese, Peruan, Bulgarian, Irish, Polish, Spanish, Swiss, American, African and Brazilian populations. The following data concerning the Lebanese population will help future investigators to study the relation of HLA-A, -B and -C alleles with common diseases in Lebanon and will add to the available international literature. This new data will serve as a major reference report in the region.

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First Report on HLA-DPB1Gene Allelic Distribution in the General Lebanese Population

Abstract: Our study will form the basis for further research to study the correlation between HLA-DPB1 and various clinical entities as well as a primer study for other transplantation centers.

Cited by 3 publications

References 16 publications

First report on HLA -DPA1 gene allelic distribution in the general Lebanese population

First report on HLA -DPA1 gene allelic distribution in the general Lebanese population

HLA population genetics: a Lebanese population

HLA Class I allele frequencies in the Lebanese population

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