First report on mangiferin (C-glucosyl-xanthone) isolated from leaves of a wild coffee plant,<i>Coffea pseudozanguebariae</i>(Rubiaceae)

Talamond, Pascale; Mondolot, Laurence; Gargadennec, Annick; Kochko, Alexandre de; Hamon, Serge; Fruchier, Alain; Campa, Claudine

doi:10.1080/12538078.2008.10516130

Cited by 42 publications

(31 citation statements)

References 30 publications

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“…Mangiferin found in the coffee plants of tropical Africa is reported in high amounts (more than 6%) in young leaves which is greater than the amounts found Mangifera zeylanica and Cyclopia genisloides . Cyclopia genistoides found mostly in South Africa and also known as honeybush, contains low amounts of mangiferin (0.70%) . The root‐bark of Hiptage madablota Geartn has also been reported to contain mangiferin (0.03%) .…”

Section: Chemosystematic: Natural Source Of Mangiferinmentioning

confidence: 99%

Mangiferin: A review of sources and interventions for biological activities

2016

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Xanthones are naturally synthesized in various biological systems such as plants, lichens, and fungi and are stored as by-products. In addition to taxonomic significance they are also important in the treatment/management of a number of human disorders. Mangiferin and its derived lead molecule have never qualified for use in a clinical trial despite a number of pharmacological studies that have proven its effectiveness as an antioxidant, analgesic, antidiabetic, antiproliferative, chemopreventive, radioprotective, cardiotonic, immunomodulatory, and diuretic. For centuries in the traditional practice of medicine in India and China the use of plants containing mangiferin has been a major component for disease management and health benefits. While it resembles biflavones, the C-glucosyl xanthone (mangiferin) has great nutritional and medicinal significance due to its unique structural characteristics. The C-glycoside link of mangiferin, mimicked to nucleophilic phloroglucinol substitution, facilitates its bioavailability and also is responsible for its antioxidant properties. Researchers have also utilized its xanthonic framework for both pharmacophoric backbone and for its use as a substitution group for synthesis and prospects. To date more than 500 derivatives using about 80 reactions have been generated. These reactions include: lipid peroxidation, phosphorylation, glycosylation, methylation, fermentation, deglycosylation, hydrolysis, polymerization, sulfation, acylation, etherification, peroxidation among others. Multiple studies on efficacy and safety have increased the global demand of mangiferin-based food supplements. This review highlights the distribution of mangiferin in plants, its isolation, and assay methods applicable to different sample matrices. In addition we include updates on various strategies and derived products intended for designated pharmacological actions. © 2016 BioFactors, 42(5):504-514, 2016.

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Section: Chemosystematic: Natural Source Of Mangiferinmentioning

confidence: 99%

Mangiferin: A review of sources and interventions for biological activities

2016

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“…It has been isolated from a variety of plants and Mangifera indica L. plant parts including leaves , fruits , stem bark , heartwood and roots . Other reports on its extraction from Coffea pseudozanguebariae leaves , Davallia solida rhizome , Cratoxylum cochinchinense leaves , Hibiscus miastrum leaves , Iris nigricans rhizome and Bersama engleriana stem bark are also available in the literature. There has being growing interest in the pharmacological potentials of mangiferin.…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical Application of Amine‐grafted Attapulgite to the Sensitive Quantification of the Bioactive Compound Mangiferin

et al. 2016

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A glassy carbon electrode (GCE) coated with a thin film of organoattapulgite was used for the voltammetric detection and quantification of mangiferin (MG), a bioactive xanthone with several therapeutic properties. The used modified attapulgite was prepared by surface grafting of [3‐(2‐aminoethylamino)propyl]trimethoxysilane. The grafted clay was characterised by SEM, CHN elemental analysis, FTIR spectroscopy and XRD techniques. The electrochemical behaviour of MG was first investigated on bare GCE by cyclic voltammetry which showed a single irreversible oxidation peak at ca 0.770 V (vs Ag/AgCl) in HCl/KCl buffer at pH 1. When the GCE was covered by the organoattapulgite, the electrode response for MG increased significantly due to favourable electrostatic interactions between MG and the protonated organoclay. A sensitive voltammetric method for the determination of MG, based on adsorptive stripping voltammetry was then developed. A linear variation of MG concentration with peak current was obtained in the range from 0.61 to 10.57 μM, with a detection limit of 2.75×10−7 M (S/N=3). Kinetic and chronocoulometric studies were also performed to characterise the diffusion of MG at the organoclay modified electrode. The interfering effect of some compounds likely to affect the stripping signal of MG was also evaluated, followed by the application of the developed method to a real biological sample.

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“…Secondary metabolites such as mangiferin, caffeoylquinic acid, caffeine, hydroxycinnamic acid, allantoic acid, allantoin, theobromine, and theophylline have found in the leaves of some species of coffee [3][4][5][6]. The coffee is also an essential source of polyphenols including caffeic acids, chlorogenic acid, coumaric acid, ferulic acid, and sinapinic acid [7].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Robusta Coffee (Coffea Canephora L.) Leaves to Staphylococcus Aureus and Escherichia Coli

Muslim

Dephinto²

2019

Asian J Pharm Clin Res

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Objective: This research aims to analyze the ability of robusta coffee leaves fraction extract to inhibit the growth of Staphylococcus aureus and Escherichia coli and also determine the minimum inhibitory concentration (MIC). Methods: Antibacterial activity evaluated by the disc diffusion method observed in four types of fraction of extract robusta coffee leaves (n-hexane, ethyl acetate, ethanol, and water). Each extract divided into three various concentrations, 5%, 10%, and 15%. Determination of antimicrobial activity in vitro by the disk diffusion method. Results: Ethyl acetate fraction of coffee leaves extract produced the largest diameter zone of inhibition of bacterial growth compared to other extraction fractions of 17.28 mm in E. coli and 18.58 mm in S. aureus. The MIC of coffee leaves extract fraction water, ethyl acetate, and n-hexane on E. coli and S. aureus is 5%, while the fraction ethanol MIC is 10%. Conclusion: The antibacterial effect of ethyl acetate fraction of coffee leaves extract showed an antibacterial effect that was better than the fraction of n-hexane, ethanol, and water.

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First report on mangiferin (C-glucosyl-xanthone) isolated from leaves of a wild coffee plant,Coffea pseudozanguebariae(Rubiaceae)

Cited by 42 publications

References 30 publications

Mangiferin: A review of sources and interventions for biological activities

Mangiferin: A review of sources and interventions for biological activities

Electroanalytical Application of Amine‐grafted Attapulgite to the Sensitive Quantification of the Bioactive Compound Mangiferin

Antibacterial Activity of Robusta Coffee (Coffea Canephora L.) Leaves to Staphylococcus Aureus and Escherichia Coli

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