First report on occurrence of bisphenol A isomers in human serum and whole blood

Li, Zhenming; Mao, Weili; Yao, Lei; Zhao, Nan; Zhang, Yingying; Zhao, Meirong; Jin, Hangbiao

doi:10.1016/j.jhazmat.2021.127549

Cited by 26 publications

(7 citation statements)

References 57 publications

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“…The mean BPA concentration in this study was lower than that reported in a previous study of Japan (4.43 ng/mL) and in the same order of magnitude with that reported in pregnant (1.99 ng/mL) and neonate subjects (2.08 ng/mL) . The median BPA-G concentration (1.08 ng/mL) was lower than that of a study in South African (4.71 ng/mL), but it was similar to that of a study in China (1.3 ng/mL) . BPC levels in human serum were previously shown to range from 0.071 to 3.8 ng/mL (median = 0.177 ng/mL) .…”

Section: Resultssupporting

confidence: 65%

“…36 The median BPA-G concentration (1.08 ng/mL) was lower than that of a study in South African (4.71 ng/mL), 37 but it was similar to that of a study in China (1.3 ng/mL). 38 BPC levels in human serum were previously shown to range from 0.071 to 3.8 ng/mL (median = 0.177 ng/mL). 14 The mean concentration of BPC in this study was about an order of magnitude higher, which may be associated with the increased use of BPC in food contact applications.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Associations of Bisphenols Exposure and Hyperuricemia Based on Human Investigation and Animal Experiments

Gao,

Bi,

et al. 2024

Environ. Sci. Technol.

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Hyperuricemia is characterized by elevated blood uric acid (UA) levels, which can lead to certain diseases. Epidemiological studies have explored the association between environmental contaminant exposure and hyperuricemia. However, few studies have investigated the role of chemical exposure in the development of hyperuricemia. Here, we sought to investigate the effects of bisphenol exposure on the occurrence of hyperuricemia. Fifteen bisphenol chemicals (BPs) were detected in human serum and urine samples collected from an area with a high incidence of hyperuricemia in China. Serum UA levels positively correlated with urinary bisphenol S (BPS), urinary bisphenol P (BPP), and serum bisphenol F (BPF). The effects of these three chemicals on UA levels in mice were explored at various exposure concentrations. An increase in serum UA levels was observed in BPS-and BPP-exposed mice. The results showed that BPS exposure increased serum UA levels by damaging the structure of the kidneys, whereas BPP exposure increased serum UA levels by disturbing purine metabolism in the liver. Moreover, BPF did not induce an increase in serum UA levels owing to the inhibition of guanine conversion to UA. In summary, we provide evidence of the mechanisms whereby exposure to three BPs disturbs UA homeostasis. These findings provide new insights into the risks of exposure to bisphenol chemicals.

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Section: Resultssupporting

confidence: 65%

Section: ■ Results and Discussionmentioning

confidence: 99%

Associations of Bisphenols Exposure and Hyperuricemia Based on Human Investigation and Animal Experiments

Gao,

Bi,

et al. 2024

Environ. Sci. Technol.

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“…Although it is already known that BPA exists in the form of several structural isomers, identified as by-products in industrial production, only a few studies described the occurrence of BPA isomers in samples of human origin. The first report on the occurrence of BPA isomers tentatively termed B 1-4 -BPA was published in 2022 by Li et al [ 80 ]. The authors also analyzed three BPA metabolites such as BPA-sulfate, BPA-glucuronide, and BPA- bisulfate disodium salt.…”

Section: Discussionmentioning

confidence: 99%

The First Evidence on the Occurrence of Bisphenol Analogues in the Aqueous Humor of Patients Undergoing Cataract Surgery

Flieger

Śniegocki

Dolar-Szczasny

et al. 2022

JCM

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Human exposure to BPs is inevitable mostly due to contaminated food. In this preliminary study, for the first time, the presence of bisphenols (BPs) in aqueous humor (AH) collected from 44 patients undergoing cataract surgery was investigated. The measurements were performed using a sensitive ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS). Chromatographic separation was achieved using a reverse-phase column and a gradient elution mode. Multiple reaction monitoring (MRM) was used. The method was validated for bisphenol A (BPA) and bisphenol F (BPF). The limits of quantification (LOQs) of both investigated analytes were 0.25 ng mL−1. The method was linear in the range of 0.25–20.0 ng mL−1 with correlation coefficients (R2) higher than 0.98. Recovery of analytes was in the range of 99.9 to 104.3% and intra-assay and inter-assay precision expressed by relative standard deviations (RSD%) were less than 5%. BPA was detected in 12 AH samples with mean concentrations of 1.41 ng mL−1. BPF was not detected at all. Furthermore, two structural isomers termed BPA-1, and BPA-2 were identified, for the first time, in 40.9% of the AH samples, with almost twice higher mean concentrations of 2.15 ng mL−1, and 2.25 ng mL−1, respectively. The total content of BPs were higher in patients with coexisting ocular pathologies such as glaucoma, age-related macular degeneration (AMD), and diabetes in comparison to cataracts alone. However, the difference between these groups did not reach statistical significance (p > 0.05). Performed investigations indicate the need for further research on a larger population with the aim of knowing the consequences of BPs’ accumulation in AH for visual function.

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“…To ask if our assay detects reproductive toxicants, we tested bisphenol A (BPA), a wellstudied chemical with known adverse effects on mammalian reproduction. BPA (Hunt et al 2003;Susiarjo et al 2007;Vrooman et al 2015) is a plastic precursor that has been found extensively in humans (Gerona et al 2016;Li et al 2022;Vandenberg et al 2007) due to its widespread use in food and beverage containers, thermal paper, toys, electronics, medical equipment and water pipes (reviewed in Catenza et al 2020). We tested BPA's dose response at 0, 30, 100, 120, 140, 160, 180 µM.…”

Section: Validation Of Screen Using Meiotic Mutants and Bisphenol A (Bpa)mentioning

confidence: 99%

A high-throughput approach to identify reproductive toxicants among environmental chemicals using an in vivo evaluation of gametogenesis in budding yeast Saccharomyces cerevisiae

Kumar

Oke

Rockmill

et al. 2022

Preprint

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Background: Environmental chemical exposures are likely making important contributions to current levels of infertility and its increasing incidence. Yet the US produces high volumes of industrial chemicals for which there is limited data on their potential human reproduction toxicity. Current assays typically used in policy and regulatory settings involve costly and time- consuming whole-animal rodent tests which limit the rapidity with which one can assess the thousands of chemicals yet to be tested. Objective: Our aim was to develop a fast and reliable strategy to evaluate a large number of chemicals for reproductive toxicity by developing a high-throughput toxicity assessment using the yeast S. cerevisiae. Methods: Yeast are chronically exposed to each environmental chemical at two doses, 30 μM and 100 μM, in a 96-well plate-based format throughout gametogenesis. Non-gametes are removed and chemicals are washed away before gamete viability is measured using absorbance at 600 nm to produce growth curves. The difference in time at half-maximal saturation with and without exposure is used to determine the extent of reproductive toxicity. Results: We validated our assay using bisphenol A (BPA), a well-established mammalian reproductive toxicant. We find that BPA in yeast has similar detrimental effects in meiosis as shown in worms and mammals. Competition assays with BPA analogs reveal that two of out of 19 BPA analogs examined (bisphenol E and 17b-estradiol) show synergistic effects with BPA at doses tested and none show antagonistic effects. Out of 179 additional environmental chemicals, we designated 57 chemicals as reproductively toxic. Finally, by comparing chemicals in our cohort that have been evaluated for reproductive toxicity in mammalian studies, we find a statistically significant association between toxic chemicals in yeast and mammals. Conclusion: We show that a high-throughput assay using yeast may be a useful approach for rapidly and reliably identifying chemicals that pose a reproductive risk.

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First report on occurrence of bisphenol A isomers in human serum and whole blood

Cited by 26 publications

References 57 publications

Associations of Bisphenols Exposure and Hyperuricemia Based on Human Investigation and Animal Experiments

Associations of Bisphenols Exposure and Hyperuricemia Based on Human Investigation and Animal Experiments

The First Evidence on the Occurrence of Bisphenol Analogues in the Aqueous Humor of Patients Undergoing Cataract Surgery

A high-throughput approach to identify reproductive toxicants among environmental chemicals using an in vivo evaluation of gametogenesis in budding yeast Saccharomyces cerevisiae

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