First results of scintillator readout with silicon photomultiplier

Herbert, D.; Saveliev, V.; Belcari, Nicola; D’Ascenzo, N.; Guerra, Alberto Del; Головин, А. В.

doi:10.1109/nssmic.2004.1466814

Cited by 16 publications

(22 citation statements)

References 5 publications

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“…The invention of PET dates back more than 30 y. However, the acceptance of PET as a routine clinical diagnostic tool has been hampered by the need for an on-site cyclotron and a radiochemistry unit for the production of the short-lived radiotracers (1)(2)(3)(4)(5)(6)(7). With the availability of commercial radiopharmacies that supply PET probes and with the relatively broad insurance coverage for a variety of clinical indications, the number of PET centers now totals more than 2,000 worldwide.…”

mentioning

confidence: 99%

Latest Advances in Molecular Imaging Instrumentation

Pichler¹,

Wehrl²,

Judenhofer³

2008

J Nucl Med

194

110

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This review concentrates on the latest advances in molecular imaging technology, including PET, MRI, and optical imaging. In PET, significant improvements in tumor detection and image resolution have been achieved by introducing new scintillation materials, iterative image reconstruction, and correction methods. These advances enabled the first clinical scanners capable of time-of-flight detection and incorporating point-spread-function reconstruction to compensate for depth-of-interaction effects. In the field of MRI, the most important developments in recent years have mainly been MRI systems with higher field strengths and improved radiofrequency coil technology. Hyperpolarized imaging, functional MRI, and MR spectroscopy provide molecular information in vivo. A special focus of this review article is multimodality imaging and, in particular, the emerging field of combined PET/MRI. PETi s a high-performance imaging technology that can image the whole-body distribution of positron-emitting biomarkers with high sensitivity. The invention of PET dates back more than 30 y. However, the acceptance of PET as a routine clinical diagnostic tool has been hampered by the need for an on-site cyclotron and a radiochemistry unit for the production of the short-lived radiotracers (1-7). With the availability of commercial radiopharmacies that supply PET probes and with the relatively broad insurance coverage for a variety of clinical indications, the number of PET centers now totals more than 2,000 worldwide.Major technologic milestones in the development of PET include the discovery of faster and brighter scintillators such as lutetium oxyorthosilicate (LSO), gadolinium oxyorthosilicate, and lutetium yttrium oxyorthosilicate. Furthermore, the continuing development of the detectors, progressing from one-to-one scintillator-to-photomultiplier-tube (PMT) coupling (8,9) to advanced block and Anger readout schemes, helps to limit the costs of a PET scanner by providing a multiplexed readout and reduced electronic channels (10-13).The use of faster scintillators enabled the transition from 2-dimensional data acquisitions for whole-body PET, using lead or tungsten collimators as septa (14-16), to 3-dimensional (3D) acquisitions (17). However, approximately an 8-fold increase in detection sensitivity is accompanied by an increased fraction of random and scattered photon events leading to degradation of image quality if not corrected during image reconstruction (18). This degradation effectively reduces the increase in sensitivity from a factor of 8 to approximately 5-fold. To achieve high-quality and quantitative PET data, various image reconstruction techniques have evolved (19). One simple approach is filtered backprojection, which is computationally fast but results in poor image quality if the count statistics of the available PET data are inadequate. Better image quality and improved spatial resolution are achieved by iterative methods such as ordered-subset expectation maximization or maximumlikelihood expectation maximiza...

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mentioning

confidence: 99%

Latest Advances in Molecular Imaging Instrumentation

Pichler¹,

Wehrl²,

Judenhofer³

2008

J Nucl Med

194

110

View full text Add to dashboard Cite

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“…Dedicated experimental estimation of this contribution is also reported in the literature (Herbert, 2006). The noise of the read-out electronics contributes to the total variance with a constant term σ el .…”

Section: Energy Resolution Of the Lso/sipm Detection Systemmentioning

confidence: 91%

“…Few examples give the impression of the extension of use of such detectors: read-out of the fiber/scintillator detectors in the neutrino T2K experiment (Yokoyama, 2009), calorimeter systems at the International Linear Collider (ILD, 2009), CMS hadron calorimeter at the Large Hadron Collider (Freeman, 2009) and others. Many projects are active on the design of PET and Gamma camera using SiPM-crystal detectors (Herbert, 2006). The aim of this chapter is to show the advantages of using the SiPM for the low photon fluxes detection in scintillator-based high energy physics and medical applications.…”

Section: Introductionmentioning

confidence: 99%

The New Photo-Detectors for High Energy Physics and Nuclear Medicine

D’Ascenzo¹,

Saveliev²

2011

Photodiodes - Communications, Bio-Sensings, Measurements and High-Energy Physics

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“…The SiPM is a novel type of photodetector that has had a rapid development and has reached a performance level that can offer significant improvements in medical imaging applications. [103][104][105][106][107] A SiPM pixel is a matrix of the GM-APDs (microcells) connected in parallel by means of a resistive layer. In this way, they permit to accurately measure the energy deposited for a moderate photon flux (N photons < N microcells ).…”

Section: Iiib4 Detector Modules For Integrated Pet/mri Scannersmentioning

confidence: 99%

An outlook on future design of hybrid PET/MRI systems

2011

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Early diagnosis and therapy increasingly operate at the cellular, molecular, or even at the genetic level. As diagnostic techniques transition from the systems to the molecular level, the role of multimodality molecular imaging becomes increasingly important. Positron emission tomography (PET) and magnetic resonance imaging (MRI) are powerful techniques for in vivo molecular imaging. The inability of PET to provide anatomical information is a major limitation of standalone PET systems. Combining PET and CT proved to be clinically relevant and successfully reduced this limitation by providing the anatomical information required for localization of metabolic abnormalities. However, this technology still lacks the excellent soft-tissue contrast provided by MRI. Standalone MRI systems reveal structure and function but cannot provide insight into the physiology and/or the pathology at the molecular level. The combination of PET and MRI, enabling truly simultaneous acquisition, bridges the gap between molecular and systems diagnosis. MRI and PET offer richly complementary functionality and sensitivity; fusion into a combined system offering simultaneous acquisition will capitalize the strengths of each, providing a hybrid technology that is greatly superior to the sum of its parts. A combined PET/MRI system provides both the anatomical and structural description of MRI simultaneously with the quantitative capabilities of PET. In addition, such a system would allow exploiting the power of MR spectroscopy (MRS) to measure the regional biochemical content and to assess the metabolic status or the presence of neoplasia and other diseases in specific tissue areas. This paper briefly summarizes state-of-the-art developments and latest advances in dedicated hybrid PET/MRI instrumentation. Future prospects and potential clinical applications of this technology will also be discussed.

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First results of scintillator readout with silicon photomultiplier

Cited by 16 publications

References 5 publications

Latest Advances in Molecular Imaging Instrumentation

Latest Advances in Molecular Imaging Instrumentation

The New Photo-Detectors for High Energy Physics and Nuclear Medicine

An outlook on future design of hybrid PET/MRI systems

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