First results of the “Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)”

Abstract

Purpose Knowledge regarding patients’ clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19. Methods Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models. Results We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66–85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46–65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25–2.42, p = 0.001; 66–85 years: aOR 1.93, 95% CI 1.36–2.74, p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49–3.81, p < 0.001 vs. individuals aged 26–45 years], male sex (aOR 1.23, 95% CI 1.01–1.50, p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09–1.72, p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04–1.69, p = 0.023) were associated with complicated stages of COVID-19 at diagnosis. Conclusion The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required.

SARS-CoV-2-directed antibodies persist for more than six months in a cohort with mild to moderate COVID-19

“…In that respect, the cohort evaluated here differs from other n.s. not significant published cohorts of patients with COVID-19 [17]. Determining the detailed natural course of anti-SARS-CoV-2 antibody titers in these convalescents with mostly relatively mild COVID-19 is of major relevance for estimating the long-term duration of protective immunity against SARS-CoV-2 in this constantly exposed, highly system relevant occupational group, and also for future comparisons with vaccination-induced immune responses in populations with few comorbidities.…”

Can we predict the severe course of COVID-19 – a systematic review and meta-analysis of indicators of clinical outcome?

“…Primarily the selection bias as suggested for example by the high case fatality rate (e.g. Zhou et al [11], 28.3%, Chen et al [115] 11.1%, and Huang et al [12] 14.6%) is likely to have impacted our results and prospective data collection to confirm findings of these studies is important [116]. In addition, we found a large number of studies (n=21, list available in supplementary file S3) that included laboratory values that were obviously incorrect, which suggests that despite peer-review in some of them, the rush of publication in this pandemic impacted the quality of reporting [117].…”

S2k-Leitlinie – Empfehlungen zur stationären Therapie von Patienten mit COVID-19

“…All rights reserved. [11][12][13][14]. Das Vorhandensein einer Adipositas ist ein weiterer wichtiger Risikofaktor, insbesondere bei männlichen Patienten und jüngeren Bevölkerungsgruppen [15].…”