On 30 October 2020, an Mw = 7.0 earthquake struck the eastern Aegean Sea. It triggered earthquake environmental effects (EEEs) on Samos Island detected by field surveys, relevant questionnaires, and Interferometric Synthetic Aperture Radar (InSAR) analysis. The primary EEEs detected in the field comprise coseismic uplift imprinted on rocky coasts and port facilities around Samos and coseismic surface ruptures in northern Samos. The secondary EEEs were mainly observed in northern Samos and include slope failures, liquefaction, hydrological anomalies, and ground cracks. With the contribution of the InSAR, subsidence was detected and slope movements were also identified in inaccessible areas. Moreover, the type of the surface deformation detected by InSAR is qualitatively identical to field observations. As regards the EEE distribution, effects were generated in all fault blocks. By applying the Environmental Seismic Intensity (ESI-07) scale, the maximum intensities were observed in northern Samos. Based on the results from the applied methods, it is suggested that the northern and northwestern parts of Samos constitute an almost 30-km-long coseismic deformation zone characterized by extensive primary and secondary EEEs. The surface projection of the causative offshore northern Samos fault points to this zone, indicating a depth–surface connection and revealing a significant role in the rupture propagation.