First Sampled High-Sensitive Cardiac Troponin T is Associated With One-Year Mortality in Sepsis Patients and 30- to 365-Day Mortality in Sepsis Survivors

Lörstad, S.; Shekarestan, S.; Jernberg, Tomas; Tehrani, Sara; Åstrand, Per; Gille-Johnson, Patrik; Persson, J.

doi:10.1016/j.amjmed.2023.04.029

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…Prognostic biomarker [95] 0.28±0.05 ng/ml (sepsis)/ 0.19±0.03 ng/ml (norm). At a level ≥0.24 ng/mL, the sensitivity was 80%, specificity was 78%; when combining 3 indicators: cTnT, lactate, 5-hydroxytryptophan -sensitivity was 86%, specificity was 92.5%…”

Section: Discussionmentioning

confidence: 99%

“…The high-sensitivity cardiac troponin T (cTnT) level is a highly effective prognostic marker for lethality in patients with sepsis [94]. It is also associated with 30-365-day mortality in survivors after the sepsis onset [95]. The combination of serum markers -lactate, cTnT, and 5-hydroxytryptophan -has a high prognostic value for assessing the sepsis condition and the course of the disease.…”

Section: Troponinmentioning

confidence: 99%

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Biological markers of sepsis

Radygina,

Mochalova

2023

Microbiology Independent Research Journal (MIR Journal)

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Currently, the issues of early sepsis diagnosis, assessment of the effectiveness of therapies conducted, and disease prognosis are extremely relevant. In the case of sepsis, timely medical assistance is complicated by the ambiguity of symptoms and the absence of a specific diagnostic test. Therefore, the search for sepsis biomarkers with diagnostic, prognostic, and therapeutic potential is underway in medical centers worldwide. This review summarizes research results regarding the diagnostic values of sepsis biomarkers – their sensitivity, specificity, and prognostic value – as presented in scientific publications indexed in international databases.

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Section: Discussionmentioning

confidence: 99%

Section: Troponinmentioning

confidence: 99%

Biological markers of sepsis

Radygina,

Mochalova

2023

Microbiology Independent Research Journal (MIR Journal)

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Development of an Extended Cardiovascular SOFA Score Component Reflecting Cardiac Dysfunction with Improved Survival Prediction in Sepsis: An Exploratory Analysis in the Sepsis and Elevated Troponin (SET) Study

Lörstad,

Wang,

Tehrani

et al. 2024

J Intensive Care Med

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Introduction The cardiovascular component of the Sequential Organ Failure Assessment (SOFA) score does not correspond with contemporary clinical practice in sepsis or identify impaired cardiac function. Our aim was to develop a modified cardiovascular SOFA component that reflects cardiac dysfunction and improves the SOFA score's 30-day mortality discrimination. Methods A cohort of sepsis patients from a previous study was divided into a training (n = 250) and test cohort (n = 253). Nine widely available measures of cardiovascular function were screened for association with 30-day mortality using natural cubic spline. High-sensitivity cardiac troponin T (hs-cTnT), N-terminal pro B-type natriuretic peptide (NT-proBNP) and heart rate (HR) were transformed into ordinal variables (0-4 points). The presence of atrial fibrillation (AF) was assigned two points. The SOFA score was extended by adding the variable points in different weights and combinations. The best-performing cardiac-extended model (CE-SOFA) was evaluated in the test cohort. Improved prognostic discrimination and calibration were assessed using logistic regression, area under receiver operating characteristic curves (AUC), Net Reclassification Improvement (NRI) index, and DeLong and Hoshmer-Lemeshow tests. Results In the training cohort, all differently weighted and combined models using hs-cTnT, NT-proBNP and AF points added to the SOFA score showed improved discriminative ability (AUC 0.67-0.75) compared to the SOFA score (AUC 0.62; NRI P < .001; DeLong P ≤ .001). In the test cohort, CE-SOFA demonstrated improved 30-day mortality discrimination compared to the SOFA score (AUC 0.72 vs 0.68), exhibiting good calibration and significantly improved discrimination using the NRI index ( P = .009) but not the DeLong test ( P = .142). Conclusions The CE-SOFA model reflects cardiac dysfunction and improves 30-day mortality discrimination in sepsis. External validation is the next step to further substantiate a revised cardiovascular component in a future SOFA 2.0.

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Биологические Маркеры Сепсиса

Радыгина,

Мочалова

2023

Microbiology Independent Research Journal (MIR Journal)

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В настоящее время проблема ранней диагностики сепсиса, оценки эффективности проводимой терапии и прогноза течения заболевания крайне актуальна. При сепсисе своевременное оказание медицинской помощи осложнено нечеткостью симптомов и отсутствием специфического диагностического теста. В связи с этим во всем мире ведется поиск биологических маркеров сепсиса: диагностических, прогностических и терапевтических. В обзоре суммированы результаты исследований по диагностической ценности биологических маркеров сепсиса, их чувствительности, специфичности и прогностической ценности из научных публикаций, представленных в международных базах данных.

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First Sampled High-Sensitive Cardiac Troponin T is Associated With One-Year Mortality in Sepsis Patients and 30- to 365-Day Mortality in Sepsis Survivors

Cited by 3 publications

References 35 publications

Biological markers of sepsis

Biological markers of sepsis

Development of an Extended Cardiovascular SOFA Score Component Reflecting Cardiac Dysfunction with Improved Survival Prediction in Sepsis: An Exploratory Analysis in the Sepsis and Elevated Troponin (SET) Study

Биологические Маркеры Сепсиса

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