First selective potentiation of Ca2+ current through neuronal T-type calcium channels by the marine terpene fulvol acetate

(1R,2S,4S,4aS,8S,8aS)-4-Hydroxy-8,8a-dimethyl-10-oxo-2,3,4,7,8,8a-hexahydro-1H-4a,1-(epoxymethano)naphthalen-2-yl acetate

“…For the synthesis, see: Selaimia-Ferdjani et al (2013). For the biological activity of the natural lactone Paralemnolide A analogue of the title compound, see: Wang et al (2012) and of related nardosinane sesquiterpene derivatives, see: Bishara et al (2008); Huang et al (2011); Petit et al (2004); Lu et al (2011). For related nardosinane sesquiterpenes whose biological activity has not been investigated, see: El-Gamal et al (2005); Huang et al (2006); Wang & Duh (2007); Wang et al (2010).…”

“…Nonius KappaCCD diffractometer Absorption correction: gaussian (JANA2006; Petříček et al, 2006) T min = 0.967, T max = 0.972 12282 measured reflections 3328 independent reflections 2774 reflections with I > 2(I) Data collection: COLLECT (Nonius, 1998); cell refinement: EVALCCD (Duisenberg et al, 2003); data reduction: COLLECT (Nonius, 1998); program(s) used to solve structure: SIR2004 (Burla et al, 2005); program(s) used to refine structure: JANA2006 (Petříček et al, 2006); molecular graphics: Mercury (Macrae et al, 2006); software used to prepare material for publication: JANA2006. (Bishara et al 2008;Huang et al 2011;Lu et al 2011;Petit et al 2004;Wang et al 2012) while the potential of others remains to be explored (El-Gamal et al 2005;Huang et al 2006;Wang and Duh 2007;Wang et al 2010). In our continuing interest in the total synthesis of biologically active compounds, we have recently proposed a synthetic strategy to access such sesquiterpene derivatives.…”