First serological evidence of Crimean-Congo haemorrhagic fever in febrile patients in Mozambique

Muianga, Argentina Felisbela; Watson, Robert J.; Varghese, Anitha; Chongo, Inocêncio; Ali, Sádia; Monteiro, Vanessa; Inalda, Flora; Chelene, Imelda; António, Virgílio; Hewson, Roger; Gudo, Eduardo Samo

doi:10.1016/j.ijid.2017.07.024

Cited by 14 publications

(9 citation statements)

References 18 publications

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“…The CCHFV exposure rate of 4.4% in this study was unexpectedly higher than those originally reported as being of 0.0% to 0.5% [ 5 , 6 ]. An anti-CCHFV IgG rate of 2.7% was recently reported in an urban setting in Maputo, Mozambique [ 15 ]. The relatively higher rates of the population exposure to RVFV and CCHFV, compared to those reported by “historical” studies in Cameroon [ 5 , 6 ], could be associated to several factors differentiating the past and present studies.…”

Section: Discussionmentioning

confidence: 99%

Serological evidence of rift valley fever Phlebovirus and Crimean-Congo hemorrhagic fever orthonairovirus infections among pygmies in the east region of Cameroon

Sadeuh-Mba

Wansi

Demanou

et al. 2018

Virol J

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BackgroundRift Valley Fever Phlebovirus (RVFV) and Crimean-Congo Hemorrhagic Fever Orthonairovirus (CCHFV) specific antibodies had been documented among humans in urban settings of the southwestern and northern Cameroon in the late 1980s. Recently, evidence for enzootic circulation of RVFV was reported among livestock in both rural and urban settings in Cameroon. However, current estimates of human exposure to RVFV and CCHFV are still to be documented in Cameroon, especially in rural areas. The aim of this study was to assess the seroprevalence of RVFV and CCHFV in rural settings in the Southeastern rain forest of Cameroon.ResultsUsing Enzyme-linked Immunosorbent Assays, the presence of RVFV and CCHFV Immunoglobulin G antibodies was investigated in plasma samples originating from 137 Pygmies from four villages of the East region of Cameroon. The studied population was found to be 12.4% (17/137) and 4.4% (6/137) seropositive for RVFV and CCHFV, respectively. The rates of RVFV IgG were comparable between the age groups and sex. Conversely, the rate of CCHFV IgG was significantly higher among the 41–60 years old participants (p = 0.02).ConclusionsThis study provides a substantial evidence of the circulation of RVFV and CCHFV among rural inhabitants of the East region of Cameroon.

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Section: Discussionmentioning

confidence: 99%

Serological evidence of rift valley fever Phlebovirus and Crimean-Congo hemorrhagic fever orthonairovirus infections among pygmies in the east region of Cameroon

Sadeuh-Mba

Wansi

Demanou

et al. 2018

Virol J

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“…African countries from which CCHF has been reported include Burkina Faso, Central Africa Republic, Democratic Republic of Congo, Egypt, Kenya, Mauritania, Namibia, Nigeria, South Africa, Senegal, Sudan, Tanzania, and Uganda 1,[7][8][9][10][11][12][13][14][15][16] and countries yet to report CCHF but with evidence of viral circulation either from serological surveys or CCHFV isolation from ticks include Algeria, Benin, Cameroon, Equatorial Guinea, Ethiopia, Ghana, Guinea, Mali, Madagascar, Morocco, Mozambique, Niger, Somalia, Tunisia, and Zimbabwe. 1,[17][18][19][20][21][22][23][24][25][26][27][28][29][30] The presence of CCHFV in Somalia was suggested after evidence of the CCHFV in Hyalomma ticks obtained from Somali cattle and sheep exported to the United Arab Emirates. 28 In the Middle East, the disease has been described in Iran, Iraq, Saudi Arabia, Oman, and the United Arab Emirates.…”

Section: Introductionmentioning

confidence: 99%

Crimean–Congo Hemorrhagic Fever Virus: Advances in Vaccine Development

Tipih

Burt

2020

BioResearch Open Access

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Crimean-Congo hemorrhagic fever (CCHF) is a severe human disease with mortality rates of up to 30%. The disease is widespread in Africa, Asia, the Middle East and Eastern Europe. The last few years have seen disease emergence in Spain for the first time and disease re-emergence in other regions of the world after periods of inactivity. Factors, such as climate change, movement of infected ticks, animals, and changes in human activity, are likely to broaden endemic foci. There are therefore concerns that CCHF might emerge in currently nonendemic regions. The absence of approved vaccines or therapies heightens these concerns; thus Crimean-Congo hemorrhagic fever virus (CCHFV) is listed by the World Health Organization as a priority organism. However, the current sporadic nature of CCHF cases may call for targeted vaccination of risk groups as opposed to mass vaccinations. CCHF vaccine development has accelerated in recent years, partly because of the discovery of CCHF animal models. In this review, we discuss CCHF risk groups who are most likely to benefit from vaccine development, the merits and demerits of available CCHF animal models, and the various approaches which have been explored for CCHF vaccine development. Lastly, we present concluding remarks and research areas which can be further explored to enhance the available CCHFV vaccine data.

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“…Thereafter, outbreaks and further cases of CCHF were reported in wide areas in countries in Africa (Uganda, South Africa, Sudan, and Mauritania), the Middle East (Iraq, United Arab Emirates, Iran, Oman, and Saudi Arabia), Europe (Bulgaria, Kosovo, Turkey, and Albania), and Asia (China, Pakistan, Afghanistan, and India) (Ergonul 2006). Serological evidence for CCHFV further suggested the potential prevalence of this virus in a wider geographic distribution including Malaysian, Nigeria, Tunisia, Sub-Saharan Africa, Iberian Peninsula (Bukbuk et al 2014(Bukbuk et al , 2016Mohd Shukri et al 2015;Muianga et al 2017;Palomar et al 2017;Wasfi et al 2016). Hence, CCHFV may be more widely distributed worldwide than is currently known.…”

Section: Introductionmentioning

confidence: 99%

Isolation, Characterization, and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province, China

et al. 2018

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Crimean-Congo hemorrhagic fever (CCHF) caused by the CCHF virus (CCHFV) is a tick-borne natural focal disease with a mortality rate of approximately 50%. CCHFV is widely prevalent in Africa, southern Asia, the Middle East, and southeast Europe. CCHF outbreaks have been reported previously in Xinjiang province, China, especially in its southern region. Epidemiological surveys conducted on ticks and animals have revealed the presence of CCHFV strains in ticks, rodents, and infected individuals from cities and counties in southern Xinjiang. Phylogenetic analyses revealed that the Chinese CCHFV strains belong to one genotype, based on complete sequences of the S segments of its negative-stranded RNA genome. The present study reports two new CCHFV strains isolated from Hyalomma asiaticum asiaticum ticks collected from Fukang City and Wujiaqu City in the northern region of Xinjiang. Viral characteristics and their evolutionary relationships were analyzed through metagenomic and reverse-transcription PCR analyses; these analyses indicated that the genotype of both strains was different from that of other Chinese strains. Furthermore, previous reports of CCHFV in Xinjiang were reviewed and phylogenetic analyses were performed. CCHFV was found to prevail in Fukang City in Junggar Basin for more than 20 years, and that Fukang City and Wujiaqu City are considered natural reservoirs of different genotypes of CCHFV strains. Our findings facilitate the understanding of CCHFV distribution in Xinjiang province and provide insights into the evolutionary relationships among Chinese CCHFV strains.

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First serological evidence of Crimean-Congo haemorrhagic fever in febrile patients in Mozambique

Abstract: This study shows for the first time that humans are exposed to CCHFV in Mozambique. It highlights the need for further work to investigate the broader extent of circulating CCHFV in the country and its clinical implications.

Cited by 14 publications

References 18 publications

Serological evidence of rift valley fever Phlebovirus and Crimean-Congo hemorrhagic fever orthonairovirus infections among pygmies in the east region of Cameroon

Serological evidence of rift valley fever Phlebovirus and Crimean-Congo hemorrhagic fever orthonairovirus infections among pygmies in the east region of Cameroon

Crimean–Congo Hemorrhagic Fever Virus: Advances in Vaccine Development

Isolation, Characterization, and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province, China

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