First serological evidence of West Nile virus in human rural populations of Gabon

Pourrut, Xavier; Nkoghe, Dieudonné; Pawęska, Janusz T.; Leroy, Eric M.

doi:10.1186/1743-422x-7-132

Cited by 17 publications

(14 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, it has been shown that seroprevalence increases with age, with a higher frequency in people over 40 years old. This age-dependent difference in seroprevalence was also found in other studies; in 2003 in Madagascar [12], and in 2010 in Gabon [8]. A greater risk of exposure of people over 40 years of age to mosquito bites could be the cause of this difference.…”

Section: Introductionsupporting

confidence: 81%

Evidence of West Nile virus circulation among humans in central northern Algeria

Hachid

Beloufa

Seghier

et al. 2019

New Microbes and New Infections

View full text Add to dashboard Cite

West Nile Virus (WNV) is the most widely distributed flavivirus worldwide. It is a mosquito-borne virus, and birds constitute its natural reservoir. Humans and equines are considered accidental hosts. Human WNV infections are usually asymptomatic or express as a mild febrile syndrome; however, in around 1% of cases they are responsible for more serious neurological diseases with a potentially lethal outcome. In the Mediterranean basin the virus circulation is regarded as endemic. Outbreaks of WNV meningoencephalitis are regularly notified, especially during summer and autumn seasons. In Algeria, although some surveys have reported WNV activity in the Sahara, to date few data are available about virus circulation in the northern part of the country. We conducted this study to detect possible WNV activity in this part of Algeria. For this purpose, in 2010 a total of 164 human sera were collected from native patients of the Algiers district and surrounding areas, then tested retrospectively for IgG anti-WNV by ELISA. Plaque reduction neutralization technique (PRNT) was used for result confirmation. In this cohort, 9.8% of the 164 collected sera returned positive for anti-WNV IgG; after confirmation by PRNT; 6.7% had specific neutralizing antibodies. No statistically significant difference was observed according to the sex or transfusion status of the patients. In conclusion, these data show for the first time serological evidence of WNV circulation in Algiers and its surrounding areas. They also highlight the need for implementing an integrated surveillance programme covering all aspects of WNV disease in order to better understand the circulation dynamics of WNV in this region. Other flaviviruses antigenically related to WNV should be investigated, given the evidence of serological cross-reaction, as specific IgG antibodies decrease after PRNT confirmation.

show abstract

Section: Introductionsupporting

confidence: 81%

Evidence of West Nile virus circulation among humans in central northern Algeria

Hachid

Beloufa

Seghier

et al. 2019

New Microbes and New Infections

View full text Add to dashboard Cite

show abstract

“…Evidence of high exposure among older people was found in previous studies in Israel [7, 13, 14] and in other countries [18, 22]. However, using the number of years lived in Israel has allowed us to differentiate between being old and spending more time in Israel.…”

Section: Discussionmentioning

confidence: 92%

The seroprevalence of West Nile Virus in Israel: A nationwide cross sectional study

et al. 2017

View full text Add to dashboard Cite

West Nile Virus (WNV) is endemic in Israel, affecting yearly 40–160 individuals. Israel is located on a central migratory path between Africa and Eurasia and most West Nile Fever (WNF) cases reported in recent years were among residents of the coastal plain. The aim of the study was to evaluate the seroprevalence of WNV among the Israeli population and to assess correlates for WNV infection. A cross-sectional nationwide serologic survey was conducted using 3,145 serum samples collected by the national Israeli serum bank during 2011–2014, representing all age and population groups in Israel. Prevalence rates of WNV IgG antibodies were determined. Logistic regressions models were applied to assess the associations between demographic characteristics and WNV seropositivity. 350 samples were positive to WNV (11.1%; 95%CI: 10.0–12.3%). In the multivariable analysis, there was a significant association between seropositivity and the Arab population group vs. Jews and others (OR = 1.86, 95%CI: 1.37–2.52), the time lived in Israel [50–59 years vs. 0–9 years; OR = 10.80 (95%CI: 1.03–113.46) and ≥60 years vs. 0–9 years; OR = 14.00 (1.32–148.31)] residence area] Coastal Plain, Inland Plain (Shfela) and Great Rift Valley vs. Upper Galilee; OR = 2.24 (95%CI: 1.37–3.65), OR = 2.18 (95%CI: 1.18–4.03), OR = 1.90 (95%CI: 1.10–3.30), respectively [and rural vs. urban settlement (OR = 1.65, 95%CI: 1.26–2.16). People, who reside in the Coastal Plain, Inland Plain and Great Rift Valley, should be aware of the risk of contracting WNV and reduce exposure to mosquito bites, using insect repellents, and wearing protective clothing. The Ministry of Environmental Protection should be active in reducing the mosquito population by eliminating sources of standing water, a breeding ground for mosquitoes.

show abstract

“…Studies conducted in several sub-Saharan countries have reported a quite variable seroprevalence in humans [120,[163][164][165] , with few documented clinical cases, but these data should be taken carefully since most studies have not addressed possible cross-reactivity with other circulating flaviviruses, and clinical cases may have been attributed to other diseases that present similar symptoms. Serological evidence of WNV infection has also been described in horses in the continent [165] .…”

Section: Africa Asia and Oceaniamentioning

confidence: 99%

West Nile virus: A re-emerging pathogen revisited

Martín-Acebes

Saiz²

2012

WJV

117

View full text Add to dashboard Cite

First serological evidence of West Nile virus in human rural populations of Gabon

Cited by 17 publications

References 16 publications

Evidence of West Nile virus circulation among humans in central northern Algeria

Evidence of West Nile virus circulation among humans in central northern Algeria

The seroprevalence of West Nile Virus in Israel: A nationwide cross sectional study

West Nile virus: A re-emerging pathogen revisited

Contact Info

Product

Resources

About