First step of odorant detection in the olfactory epithelium and olfactory preferences differ according to the microbiota profile in mice

Naudon, Laurent; François, Adrien; Mariadassou, Mahendra; Monnoye, Magali; Philippe, Catherine; Bruneau, Aurélia; Dussauze, Marie; Rué, Olivier; Rabot, Sylvie; Meunier, Nicolas

doi:10.1016/j.bbr.2020.112549

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…It draws us to things or away from things based on how we perceive odors. This includes our food as shown in Table 3 [115][116][117][118]. Characterization of microbiota among three distinct groups of mice: C3H/HeN, Swiss, and BALB/cByJ.…”

Section: Smellmentioning

confidence: 99%

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Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert

2021

Biomedicines

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The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, and obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to comorbid NCDs.

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Section: Smellmentioning

confidence: 99%

“…It draws us to things or away from things based on how we perceive odors. This includes our food as shown in Table 3 [ 115 , 116 , 117 , 118 ].…”

Section: Who Behavioral Modification #1: Eat a Healthy Diet (In Spite Of The Microbiota-driven Sense Control)mentioning

confidence: 99%

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert

2021

Biomedicines

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show abstract

“…It draws us to things or away from things based on how we perceive odors. This includes our food as shown in Table 3 [115][116][117][118]. As with taste there are thresholds of odor detection and there is the nature of the scent itself.…”

Section: Smellmentioning

confidence: 99%

“…Nardon et al [115] found evidence that microbiota can affect the first step in odor detection at the level of the olfactory epithelium. Studies in three different groups of mice examined the effects of microbiota on nasal epithelium and odor detection and preferences in three different groups of mice using physiological, biochemical, behavioral, and microbiological analyses.…”

Section: Sensementioning

confidence: 99%

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert¹

2021

Preprint

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The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to co-morbid NCDs.

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“…The metabolism of aroma compounds in the oral cavity originates from the presence of xenobiotic-metabolizing enzymes in saliva and the oral mucosa. , In addition to host enzymes, the oral cavity is colonized by microorganisms, which have their own metabolism and enzymes. A body of evidence suggests that oral microbiota metabolism takes part in in-mouth aroma metabolism through the involvement of specific microbial enzymes. − For instance, glycosidases and carbon–sulfur lyases (C–S lyases) have been suggested to play a role in the metabolism of two classes of aroma precursors, namely glycoside conjugates and cysteine conjugates, respectively . These aroma precursors are not perceived as odorants mainly due to the presence of a hydrophilic group, reducing their volatility and binding to the receptors (e.g., the sugar group or cysteine group).…”

Section: Introductionmentioning

confidence: 99%

Metabolism of Cysteine Conjugates and Production of Flavor Sulfur Compounds by a Carbon–Sulfur Lyase from the Oral Anaerobe Fusobacterium nucleatum

Neiers

Gourrat

Canon

et al. 2022

J. Agric. Food Chem.

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Flavor perception is a key factor in the acceptance or rejection of food. Aroma precursors such as cysteine conjugates are present in various plant-based foods and are metabolized into odorant thiols in the oral cavity. To date, the involved enzymes are unknown, despite previous studies pointing out the likely involvement of carbon–sulfur lyases (C–S lyases) from the oral microbiota. In this study, we show that saliva metabolizes allyl-cysteine into odorant thiol metabolites, with evidence suggesting that microbial pyridoxal phosphate-dependent C–S lyases are involved in the enzymatic process. A phylogenetic analysis of PatB C–S lyase sequences in four oral subspecies of Fusobacterium nucleatum was carried out and led to the identification of several putative targets. FnaPatB1 from F. nucleatum subspecies animalis, a putative C–S lyase, was characterized and showed high activity with a range of cysteine conjugates. Enzymatic and X-ray crystallographic data showed that FnaPatB1 metabolizes cysteine derivatives within a unique active site environment that enables the formation of flavor sulfur compounds. Using an enzymatic screen with a library of pure compounds, we identified several inhibitors able to reduce the C–S lyase activity of FnaPatB1 in vitro, which paves the way for controlling the release of odorant sulfur compounds from their cysteine precursors in the oral cavity.

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First step of odorant detection in the olfactory epithelium and olfactory preferences differ according to the microbiota profile in mice

Cited by 8 publications

References 40 publications

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Metabolism of Cysteine Conjugates and Production of Flavor Sulfur Compounds by a Carbon–Sulfur Lyase from the Oral Anaerobe Fusobacterium nucleatum

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