First study of Seoul virus (SEOV) in urban rodents from newly urbanized areas of Gran La Plata, Argentina

Fitte, Bruno; Brignone, Julia; Sen, Carina; Robles, María del Rosario

doi:10.1016/j.bjid.2022.102730

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…In total, 87 brown rats were caught from different sites within the urban park between 2020 and 2022. The detected overall seroprevalence (17.2%) was quite high and comparable to what has been observed in other cities [ 9 ]. Nevertheless, reports on SEOV seroprevalence in Lyon city are limited; therefore, it should be followed.…”

Section: Discussionsupporting

confidence: 86%

“…In turn, densely populated rodent communities near human settlements increase the risk of human-rodent contact, and subsequent transmission of rodent-borne disease agents to humans, creating favorable conditions for the emergence and spread of zoonoses [8]. Therefore, the risk of SEOV is indicative of inequality within society [9] as rat infestations in urban areas tend to increase with city growth and rising urban poverty [10]. Tropical and subtropical cities in America, Asia and Africa are particularly exposed to rodent-associated problems due to sometimes limited health and sanitary infrastructure combined with rapid population growth [11].…”

Section: Introductionmentioning

confidence: 99%

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Evolution and genetic characterization of Seoul virus in wild rats Rattus norvegicus from an urban park in Lyon, France 2020–2022

Alburkat,

Smura,

Bouilloud

et al. 2024

PLoS Negl Trop Dis

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Background Seoul virus (SEOV) is an orthohantavirus primarily carried by rats. In humans, it may cause hemorrhagic fever with renal syndrome (HFRS). Its incidence is likely underestimated and given the expansion of urban areas, a better knowledge of SEOV circulation in rat populations is called for. Beyond the need to improve human case detection, we need to deepen our comprehension of the ecological, epidemiological, and evolutionary processes involved in the transmission of SEOV. Methodology / Principal findings We performed a comprehensive serological and molecular characterization of SEOV in Rattus norvegicus in a popular urban park within a large city (Lyon, France) to provide essential information to design surveillance strategies regarding SEOV. We sampled rats within the urban park of ‘La Tête d’Or’ in Lyon city from 2020 to 2022. We combined rat population genetics, immunofluorescence assays, SEOV high-throughput sequencing (S, M, and L segments), and phylogenetic analyses. We found low structuring of wild rat populations within Lyon city. Only one sampling site within the park (building created in 2021) showed high genetic differentiation and deserves further attention. We confirmed the circulation of SEOV in rats from the park with high seroprevalence (17.2%) and high genetic similarity with the strain previously described in 2011 in Lyon city. Conclusion/Significance This study confirms the continuous circulation of SEOV in a popular urban park where the risk for SEOV transmission to humans is present. Implementing a surveillance of this virus could provide an efficient early warning system and help prepare risk-based interventions. As we reveal high gene flow between rat populations from the park and the rest of the city, we advocate for SEOV surveillance to be conducted at the scale of the entire city.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Evolution and genetic characterization of Seoul virus in wild rats Rattus norvegicus from an urban park in Lyon, France 2020–2022

Alburkat,

Smura,

Bouilloud

et al. 2024

PLoS Negl Trop Dis

View full text Add to dashboard Cite

show abstract

“…In total, 87 brown rats were caught from different sites within the urban park between 2020 and 2022. The detected overall seroprevalence (17.2%) was quite high and comparable to what has been observed in other cities (28). All seropositive rats except one were sexually mature, and they were trapped in several sampling sites within the park.…”

Section: Discussionsupporting

confidence: 84%

Evolution and Genetic Characterization of Seoul Virus in Wild RatsRattus Norvegicusfrom an urban park in Lyon, France 2020-2022

Alburkat

Smura

Bouilloud

et al. 2023

Preprint

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Seoul virus (SEOV) is an orthohantavirus primarily carried by rats that can cause hemorrhagic fever with renal syndrome (HFRS) in humans. Nowadays, its incidence is likely underestimated. We developed a comprehensive serological and molecular characterization of SEOV in Rattus norvegicus population from a popular urban park within a large city (Park of La Tete dOr, Lyon, France) between 2020 and 2022. We confirmed the circulation of SEOV in rats from the park (seroprevalence 17.2%). The SEOV strains detected showed high genetic similarity with the strain previously described in 2013 in this area. We found low structuring of wild rat populations within Lyon city. This study confirms the circulation of SEOV in Lyon city, in a park where opportunities for SEOV transmission to humans are numerous. Given the high gene flow between rat populations in the park and the rest of the city, we recommend conducting city-wide SEOV surveillance.

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Public Health Importance of Hantavirus Hemorrhagic Fevers in Colombia and South America

Mattar,

Chevel,

Calderon

et al. 2024

The Latin American Studies Book Series

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First study of Seoul virus (SEOV) in urban rodents from newly urbanized areas of Gran La Plata, Argentina

Cited by 3 publications

References 15 publications

Evolution and genetic characterization of Seoul virus in wild rats Rattus norvegicus from an urban park in Lyon, France 2020–2022

Evolution and genetic characterization of Seoul virus in wild rats Rattus norvegicus from an urban park in Lyon, France 2020–2022

Evolution and Genetic Characterization of Seoul Virus in Wild RatsRattus Norvegicusfrom an urban park in Lyon, France 2020-2022

Public Health Importance of Hantavirus Hemorrhagic Fevers in Colombia and South America

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