First three cases of cat‐associated zoonotic cutaneous sporotrichosis in Colombia

Gallo, Simón; Arias-Rodriguez, Camilo; Sánchez-Cifuentes, Erika A; Santa-Vélez, Catalina; Larrañaga-Piñeres, Isabel; Gaviria-Barrera, Maria E; Vásquez-Ochoa, Luz A.; Montoya, Daniel; Jimenez-Alzate, Maria del Pilar

doi:10.1111/ijd.16377

Cited by 4 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sporothrix brasiliensis and Sporothrix schenckii are the main causative agents of feline sporotrichosis [1][2][3][4][5][6], with cases mostly reported in South America, Asia, and the United States [1,[7][8][9][10]. S. brasiliensis is the main etiological agent of sporotrichosis in Brazil, where epizootic as well as zoonotic transmission related to cats have been reported over the last twenty-five years [2,[11][12][13][14][15][16], although the isolation of this species from the environment suggests that sapronotic transmission can also occur [17].…”

Section: Introductionmentioning

confidence: 99%

A Randomized Clinical Trial Comparing Itraconazole and a Combination Therapy with Itraconazole and Potassium Iodide for the Treatment of Feline Sporotrichosis

Reis,

Pereira,

Miranda

et al. 2024

JoF

View full text Add to dashboard Cite

Feline sporotrichosis is an endemic disease with high occurrence in Brazil. Itraconazole (ITZ) remains the drug of choice for treating this disease in cats, despite the increasing reports of therapeutic failure. A controlled, randomized clinical trial was performed on 166 naive cats with sporotrichosis to assess the effectiveness and safety of the combination therapy with ITZ and potassium iodide (KI) compared with ITZ monotherapy. Cats were randomly allocated into two treatment groups: G1—ITZ 100 mg/cat/day—and G2—ITZ 100 mg/cat/day + KI 2.5–20 mg/kg/day. Cats treated in G2 presented 77% more risk of reaching a clinical cure (a positive effect) than those treated in G1, even when controlled by negative predictors. The survival curves of the two treatment protocols indicate that a clinical cure was achieved faster in G2. An increase in the KI dose was necessary in 28 cats due to the persistence of clinical signs. Adverse reactions were equally frequent in both groups and manageable with a temporary drug suspension and/or a hepatoprotective therapy. The combination therapy was associated with a higher cure rate and a shorter treatment time, suggesting that ITZ+KI arises as a better option for treating feline sporotrichosis and should be considered the first-line treatment, especially in the presence of negative predictors.

show abstract

Section: Introductionmentioning

confidence: 99%

A Randomized Clinical Trial Comparing Itraconazole and a Combination Therapy with Itraconazole and Potassium Iodide for the Treatment of Feline Sporotrichosis

Reis,

Pereira,

Miranda

et al. 2024

JoF

View full text Add to dashboard Cite

show abstract

“…Within the pathogenic species, S. brasiliensis is categorized as the most virulent, becoming the main etiological agent of zoonotic transmission between cats and humans [ 37 , 38 ]. Transmission can occur through scratches, bites, or contact with exudates from skin lesions of infected cats [ 39 , 40 , 41 , 42 , 43 ]. In addition, cats can carry the fungus in their claws, which may have an important role in the epidemiology of the disease [ 42 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

Sporotrichosis Outbreak Due to Sporothrix brasiliensis in Domestic Cats in Magallanes, Chile: A One-Health-Approach Study

Thomson

González

Blank³

et al. 2023

JoF

View full text Add to dashboard Cite

Sporotrichosis is an implantation mycosis with subcutaneo-lymphatic or, more rarely, a viscerally disseminated affection; it can be acquired through traumatic percutaneous inoculation of the fungus present in soil or plant matter, or by feline scratching. Among the causative agents, Sporothrix brasiliensis is considered the most virulent species with a high prevalence in Brazil and recently in Argentina. Objective: Describe a S. brasiliensis outbreak in domestic and feral cats detected in the Magallanes region of southern Chile. Materials and Methods: Between the months of July and September 2022, three cats presented with suppurative subcutaneous lesions located mainly on the head and thoracic limbs. The cytology revealed the presence of yeasts with morphological characteristics suggestive of Sporothrix spp. The histopathology confirmed pyogranulomatous subcutaneous lesions associated with the presence of the same yeasts. The fungal culture followed by the partial gene sequence and analysis of the ITS region confirmed the diagnosis of the S. brasiliensis as the causative agent. The cats were treated with itraconazole associated in one case with potassium iodide. The evolution of the patients was favorable in all cases. Conclusions: An outbreak caused by S. brasiliensis was detected in domestic and feral felines in austral Chile. The correct identification of this fungus and antifungigram is essential for treatment decisions and for designing dissemination control and prevention programs under a one health approach that consider the health of people, animals, and the environment.

show abstract

The rising incidence of feline and cat‐transmitted sporotrichosis in Latin America

Santos,

Nascimento,

Barbosa

et al. 2024

Zoonoses and Public Health

View full text Add to dashboard Cite

IntroductionSporotrichosis is a subcutaneous mycosis caused by different species of thermodimorphic fungi belonging to the genus Sporothrix. These fungi may affect a wide range of warm‐blooded animals, including humans, dogs and, mainly, cats.MethodsIn this article, we conducted a narrative literature review about the status of feline and cat‐transmitted sporotrichosis in Latin American countries, with emphasis on Brazil.ResultsFrom a global perspective, Latin America is one of the main foci of human and feline sporotrichosis. In humans, the disease has been reported in several countries, with endemic transmission occurring in Brazil, Colombia, Costa Rica, Guatemala, Mexico and Uruguay. Sporothrix brasiliensis is the most common species identified in human cases in Brazil, whereas Sporothrix schenckii predominates in other countries.ConclusionDomestic cats are the main source of infection in the zoonotic transmission cycle of sporotrichosis in Latin America. Cases of feline sporotrichosis have been reported in several countries, including Argentina, Brazil, Chile, Colombia, Mexico, Panama, Paraguay and Peru.

show abstract

First three cases of cat‐associated zoonotic cutaneous sporotrichosis in Colombia

Cited by 4 publications

References 13 publications

A Randomized Clinical Trial Comparing Itraconazole and a Combination Therapy with Itraconazole and Potassium Iodide for the Treatment of Feline Sporotrichosis

A Randomized Clinical Trial Comparing Itraconazole and a Combination Therapy with Itraconazole and Potassium Iodide for the Treatment of Feline Sporotrichosis

Sporotrichosis Outbreak Due to Sporothrix brasiliensis in Domestic Cats in Magallanes, Chile: A One-Health-Approach Study

The rising incidence of feline and cat‐transmitted sporotrichosis in Latin America

Contact Info

Product

Resources

About