First-trimester bleeding and pregnancy outcome in singletons after assisted reproduction

Sutter, Petra De; Bontinck, Julie; Schutysers, Valerie; Elst, Josiane Van Der; Gerris, Jan; Dhont, Marc

doi:10.1093/humrep/del054

Cited by 64 publications

(23 citation statements)

References 31 publications

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“…Bleeding during first trimester was associated with increased risk of preterm delivery. 5 Because of impaired implantation and invasive trophoblasts, spontaneous abortion may occur in early pregnancy while preterm delivery, PPROM, placental ablation and preeclampsia may happen in later period. Ultrasound examination was considered an important investigation for the diagnosis of the cause of bleeding.…”

Section: Discussionmentioning

confidence: 99%

First trimester bleeding and pregnancy outcome

Kamble

Bava

Shukla

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: The outcome of first trimester vaginal bleeding is a matter of debate. This study sought to determine the maternal and perinatal outcome in patients presenting with first trimester vaginal bleeding.Methods: This prospective observational study was done on 1007 women with first trimester vaginal bleeding at a tertiary care hospital in Mumbai over a period of one year. A detailed history was taken and USG was done to confirm diagnosis. All these patients were evaluated for the outcomes including threatened abortions, spontaneous, complete or incomplete abortions, sub-chorionic hematoma, Intra-uterine Fetal Demise, missed abortions, second and third trimester bleeding, Intra-uterine Growth Restriction, premature rupture of membranes and preterm deliveries.Results: Out of the 11835 confinements 1007 patients presented with first trimester vaginal bleeding. The incidence was highest (52.3%) in the age group of 21-30 years. 63.9% primigravidas presented with first trimester bleeding as compared to 36.1% of multigravidas. It was seen that 76.9% patients who presented before 6 weeks aborted whereas only 7% patients who presented after 10 weeks aborted. Out of the 163 patients that continued pregnancy after first trimester vaginal bleeding 1.8% had a second trimester abortion, 15.3% went into preterm labour 6.75% has premature rupture of membranes and 1.8% had antepartum hemorrhage.Conclusions: According to the results of present study, first trimester vaginal bleeding predicts auxiliary maternal and fetal complications. Also, as the clinical intermediation has an important role in continuance of pregnancy and in reducing the fetal complications precise management and planning by physician is important.

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Section: Discussionmentioning

confidence: 99%

First trimester bleeding and pregnancy outcome

Kamble

Bava

Shukla

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…20 RDS and Birth asphyxia significantly associated with preterm birth, which is agreement with findings where the risk of RDS and asphyxia was higher in women with preterm. 21,22 The data for some variables were collected based on the medical records of the subjects and that; there might be a potential risk for quality of recorded data. Other limitation was that, where the mothers did not remember the date of the first day of last menstrual period accurately, we calculated gestational age by obstetric ultrasound taken in first trimester.…”

Section: Discussionmentioning

confidence: 99%

Retrospective study factors related to preterm birth in Government Raja Mirasudar hospital and obstetric and perinatal outcome

Soundarajan¹,

Poovathi²,

Veerapandi³

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…De Sutter et al found that the higher incidence of first-trimester bleeding was also associated with an increased risk for pregnancy complications in pregnancies following ART [28]. The study reported a lower mean duration of pregnancy and lower birth weight in pregnancies complicated with first trimester vaginal bleeding.…”

Section: Discussionmentioning

confidence: 99%

Obstetric outcome in donor oocyte pregnancies: a matched-pair analysis

Stoop

Baumgarten

Haentjens

et al. 2012

Reprod Biol Endocrinol

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BackgroundTo investigate the obstetrical and perinatal impact of oocyte donation, a cohort of women who conceived after OD was compared with a matched control group of women who became pregnant through in vitro fertilisation with autologous oocytes (AO).MethodsA matched-pair analysis has been performed at the Centre for Reproductive Medicine of the UZ Brussel, Dutch speaking Free University of Brussel. A total of 410 pregnancies resulted in birth beyond 20 weeks of gestation occurring over a period of 10 years, including 205 oocyte donation pregnancies and 205 ICSI pregnancies with autologous oocytes (AO). Patients in the OD group were matched on a one-to-one basis with the AO group in terms of age, ethnicity, parity and plurality. Matched groups were compared using paired t-tests for continuous variables and McNemar test for categorical variables. A conditional logistic regression analyses was performed adjusting for paternal age, age of the oocyte donor, number of embryos transferred, and singleton/twin pregnancy.ResultsOocyte donation was associated with an increased risk of pregnancy induced hypertension (PIH) (matched OR: 1.502 CI: 1.024-2.204), and first trimester bleeding (matched OR: 1.493 CI: 1.036-2.15). No differences were observed between the two matched groups with regard to gestational age, mean birth weight and length, head circumference and Apgar scores.ConclusionsOocyte donation is associated with an increased risk for PIH and first trimester bleeding independent of the recipients’ age, parity and plurality, and independent of the age of the donor or the partner. However, oocyte donation has no impact on the overall perinatal outcome.

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First-trimester bleeding and pregnancy outcome in singletons after assisted reproduction

Cited by 64 publications

References 31 publications

First trimester bleeding and pregnancy outcome

First trimester bleeding and pregnancy outcome

Retrospective study factors related to preterm birth in Government Raja Mirasudar hospital and obstetric and perinatal outcome

Obstetric outcome in donor oocyte pregnancies: a matched-pair analysis

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